Article
Multidisciplinary Sciences
Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, Ryogo Shimizu, Souma Yamanaka, Atsushi Abe, Hitoshi Omura, Kazunori Kawaguchi, Hikari Okada, Taro Yamashita, Tomoki Yoshikawa, Kazuhiro Takimoto, Motoko Taharaguchi, Shogo Takatsuka, Yoshitsugu Miyazaki, Toshikatsu Tamai, Yamato Tanabe, Makoto Kurachi, Yasuhiko Yamamoto, Shuichi Kaneko, Kunio Matsumoto, Toshinari Takamura, Masao Honda
Summary: This study reveals that leukocyte cell-derived chemotaxin 2 (LECT2) promotes RIG-I-mediated innate immune response and inhibits lymphocytic choriomeningitis virus replication by preventing RIG-I degradation. It also uncovers the crosstalk between LECT2-MET and HGF-MET signaling pathways, suggesting the therapeutic potential of targeting LECT2 in infectious diseases and cancer.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Gang Chi, Jin-Hong Pei, Xue-Qing Li
Summary: The study found that RAE1 is highly expressed in HCC tissues and is associated with pathological characteristics and prognosis of HCC. RAE1 expression level can accurately distinguish tumor tissues from normal tissues. RAE1 is closely related to key protein-protein interactions involved in cell division and mitotic checkpoint, suggesting it as a potential therapeutic target for HCC.
BMC BIOINFORMATICS
(2022)
Review
Immunology
Wei-Jian Mei, Mi Mi, Jing Qian, Nan Xiao, Ying Yuan, Pei-Rong Ding
Summary: Colorectal cancers with high microsatellite instability and deficient mismatch repair have different characteristics compared to normal CRC, but the testing rates for MSI and MMR remain low in clinical practice. Insufficient testing fails to identify patients with these types of CRC who could benefit from immunotherapy. Understanding the importance of MMR/MSI status in the clinical characteristics and prognosis of CRC may help improve testing rates and guide the development of more effective therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Guoshun Zhang, Hua Shang, Bin Liu, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: ATP2A1 is a potential prognostic biomarker in colorectal cancer, with high expression associated with significantly lower overall survival rates. Inhibiting the autophagy process by ATP2A1 can significantly suppress the proliferation of colorectal cancer cells.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Fanny E. R. Vuik, Stella A. Nieuwenburg, Iris D. Nagtegaal, Ernst J. Kuipers, Manon C. W. Spaander
Summary: The study found that younger patients were more likely to have signet-ring cells and poorly differentiated tumors, as well as a higher risk of lymph node metastases. Over time, there was an increase in the proportion of colorectal cancers diagnosed in women, especially in the younger age group.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Hangcheng Xu, Yiqun Han, Yun Wu, Yan Wang, Jiayu Wang, Binghe Xu
Summary: This article aims to clarify the clinicopathological characteristics and prognosis of Microinvasive breast cancer (MIBC) in different molecular subtypes and provide feasible suggestions for clinical practice. The study found that HR+/HER2+ subtype had the best prognosis, and radiotherapy could provide additional survival benefits for HR+/HER2- and HR+/HER2+ MIBC patients. Chemotherapy was not recommended for MIBC patients.
Article
Oncology
Barbora Pekova, Vlasta Sykorova, Karolina Mastnikova, Eliska Vaclavikova, Jitka Moravcova, Petr Vlcek, Petr Lastuvka, Milos Taudy, Rami Katra, Petr Bavor, Daniela Kodetova, Martin Chovanec, Jana Drozenova, Jaromir Astl, Petr Hrabal, Josef Vcelak, Bela Bendlova
Summary: NTRK fusion genes are important yet understudied molecular markers in thyroid cancer. Identification of these genes can improve diagnosis and prognosis, and there are recommendations for surgery and prognostic factors for NTRK-rearranged tumors. Detection of NTRK fusion-positive carcinomas and their correlation with clinical data underscores their diagnostic and prognostic significance.
Article
Oncology
Dina Sweed, Enas Sweed, Inas Moaz, Asmaa Mosbeh, Yahya Fayed, Sara Mohamed Abd Elhamed, Eman Sweed, Mahmoud Macshut, Shimaa Abdelsattar, Shimaa Kilany, Sara A. Saied, Reda Badr, Mahmoud S. Abdallah, Nermine Ehsan
Summary: This study aims to investigate the clinical and pathological criteria of hepatocellular carcinoma (HCC), update the morpho-molecular classifications, and provide a diagnostic guide. Through analysis of 530 HCC cases, it was found that hepatitis C virus is still the main cause of HCC in Egypt, and HCC treated with direct-acting antiviral agents shows a more aggressive course compared to interferon-related HCC. Age, gender, alpha-fetoprotein level, tumor size, and background liver were identified as important prognostic parameters.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Johnathan Kent, Philip Erwin, Daniel Haraf, Chih-Yi Liao, Joseph Durham, Peter Angelos, Nishant Agrawal, Brandon Jackson Baird, Maria Lucia L. Madariaga
Summary: Laryngotracheal resection and reconstruction after dabrafenib/trametinib treatment has been shown to be safe and effective in locoregionally advanced BRAF v600e mutated anaplastic thyroid carcinoma. This treatment improves rates of microscopically margin-negative resection and durable locoregional control.
ANNALS OF THORACIC SURGERY
(2023)
Article
Medicine, Research & Experimental
Jianqing Yu, Xianfeng Xia, Yujuan Dong, Zhongqin Gong, Gang Li, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 is significantly down-regulated in HCC tumor tissues and its high expression is associated with better prognosis. CYP1A2 functions as a tumor suppressor in HCC by inhibiting HGF/MET signaling and MMPs expression, thus reducing cell growth and invasion capabilities.
Article
Endocrinology & Metabolism
Jiapeng Huang, Wei Sun, Qingfu Zhang, Zhihong Wang, Wenwu Dong, Dalin Zhang, Chengzhou Lv, Liang Shao, Ping Zhang, Hao Zhang
Summary: Poorly differentiated thyroid carcinoma (PDTC) is a rare, highly invasive cancer with poor prognosis, where tumor size, extrathyroidal extension, distant metastases, proportion of poorly differentiated areas, and Ki-67 labeling index are associated with adverse outcomes. Extrathyroidal extension and distant metastases are independent risk factors for poor prognosis.
ENDOCRINE PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Jie Sun, Jinling Xu, Chao Sun, Minying Zheng, Yuwei Li, Siwei Zhu, Shiwu Zhang
Summary: The mSEPT9 test improves compliance of endoscopy for CRC, showing specificity and sensitivity better than FOBT. Levels of mSEPT9 are associated with clinical features, gene mutations, and prognosis of CRC, making it an important biomarker for early diagnosis and prognosis assessment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Yu Zhang, Xiulan Luo, Min Chen, Libo Yang, Ting Lei, Tianjie Pu, Bing Wei, Hong Bu, Zhang Zhang
Summary: This study compared the clinicopathologic features and prognosis of pleomorphic invasive lobular carcinoma (P-ILC) and classic ILC (C-ILC). P-ILCs had larger tumor sizes and stages compared to C-ILCs, and the prognosis differed by biomarker subtype. The bone was the most common metastatic site for P-ILCs.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Respiratory System
Caixia Ding, Yanyi Qiu, Juan Zhang, Wei Wei, Hongbian Gao, Yong Yuan, Xiaomin Wang
Summary: This study found that MET exon 14 skipping is a rare mutation in NSCLC, and it is associated with the pathogenesis and progression of the disease. The analysis of 257 NSCLC cases using PCR and IHC showed a correlation between MET overexpression and amplification with MET exon 14 skipping, but no correlation with prognosis.
BMC PULMONARY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hans-Juergen Schulten, Fatima Al-Adwani, Haneen A. Bin Saddeq, Heba Alkhatabi, Nofe Alganmi, Sajjad Karim, Deema Hussein, Khalid B. Al-Ghamdi, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed H. Al-Qahtani
Summary: This study provides a comprehensive overview of the expression effects of IDH mutations in different isogenic disease models, identifying several biomarkers associated with IDH mutations that could be relevant for further research or clinical applications.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mourad Assidi, Abdelbaset Buhmeida, Maryam H. Al-Zahrani, Jaudah Al-Maghrabi, Mahmood Rasool, Muhammad I. Naseer, Heba Alkhatabi, Abdulmajeed F. Alrefaei, Ali Zari, Razan Elkhatib, Adel Abuzenadah, Peter N. Pushparaj, Muhammad Abu-Elmagd
Summary: FZD6 expression in breast cancer is significantly associated with tumor invasion, tumor grade, and patient survival outcomes. It has a potential prognostic role in young female breast cancer patients, and is involved in the molecular silencing machinery of the Wnt/FZD6 signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Urology & Nephrology
Afnan Elsayed, Jaudah Al-Maghrabi, Abdelrazak Meliti
Summary: Angioleiomyoma is a common benign smooth muscle tumor, but testicular involvement is extremely rare. This case report represents the third reported case in English literature.
UROLOGY CASE REPORTS
(2022)
Article
Medicine, General & Internal
Jaudah A. Al-Maghrabi
Summary: This study documented the clinicopathological features of Rosai-Dorfman disease in two tertiary hospitals in the western region of Saudi Arabia. The results showed that surgical excision was generally curative and the prognosis was good with rare recurrence.
SAUDI MEDICAL JOURNAL
(2022)
Article
Genetics & Heredity
Norah A. Al Sharhan, Safia A. Messaoudi, Saranya R. Babu, AbdulRauf B. Chaudhary, Abdullah A. Alsharm, Abdulmajeed F. Alrefaei, Sultan Kadasah, Muhammad Abu-Elmagd, Mourad Assidi, Abdelbaset Buhmeida, Angel Carracedo, Wassim Y. Almawi
Summary: This study investigates the use of circulating cell-free DNA (cfDNA) to examine microsatellite instability (MSI) and loss of heterozygosity (LOH) for early breast cancer diagnosis. The results show that cfDNA plasma concentrations are significantly higher in breast cancer patients compared to healthy controls. Furthermore, LOH and MSI are detected in a significant proportion of cfDNA samples, highlighting the potential of cfDNA as a non-invasive diagnostic tool.
Review
Surgery
Saleh Baeesa, Yazid Maghrabi, Rana Moshref, Jaudah Al-Maghrabi
Summary: This study presents two cases of optic pathway-hypothalamic glioma (OPHG) in infants and provides a systematic review of the literature. The review identified that younger age, pilocytic or pilomyxoid astrocytoma histopathology, and chiasmal/hypothalamic locations are associated with a higher risk of intertumoral hemorrhage and poor prognosis in OPHG.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Jaudah Al-Maghrabi, Mohamad N. Khabaz
Summary: This study assessed the immunohistochemistry phenotype of COX-2 in breast cancer and correlated it with histological and clinical prognostic factors. The results showed a significant connection between COX-2 expression and breast cancer, as well as its association with aggressive subtypes and poor prognosis.
SAUDI MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Jaudah Al-Maghrabi, Wafaey Gomaa
Summary: This study aims to investigate the relationship between COX-2 immunostaining and clinicopathological parameters in thyroid carcinoma to assess the prognostic significance of immunostaining results.
ANNALS OF SAUDI MEDICINE
(2022)
Article
Medicine, General & Internal
Jaudah A. Al-Maghrabi
Summary: This study documented the clinicopathological features of primary renal lymphoma (PRL) in two tertiary hospitals in the western region of Saudi Arabia. The study included 17 cases of PRL, with males accounting for 64.7% and females accounting for 35.3%. The most common pathological type was diffuse large B-cell lymphoma. According to follow-up data, the one-year overall survival rate was 71% and the two-year overall survival rate was 43%.
SAUDI MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jaudah Al-Maghrabi, Sahar Al-Maghrabi
Summary: This study examined the clinicopathological features of primary esophageal lymphoma (PEL) at two tertiary hospitals in the western region of Saudi Arabia. The records of the hospitals showed only eight cases of PEL, with a majority of male patients aged between 50 and 74 years. Clinical manifestations included dysphagia and weight loss. The findings contribute to a better understanding and management of PEL.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Ammar G. Chaudhary, Fadi M. AlReefi, Riad G. Abou Zahr, Hossam A. Elzeftawy, Saleh S. Alghamdi, Areej A. Bushnag, Jaudah A. Al-Maghrabi, Iman S. Abumansour
Summary: This case report details left ventricular hypertrophy and neuropathy in a middle-aged woman caused by a rare transthyretin variant, providing further evidence for the pathogenicity of this variant.
Review
Health Care Sciences & Services
Abdelbaset Buhmeida, Mourad Assidi, Bruce Budowle
Summary: Despite the success in treating acute conditions, healthcare systems have struggled with noncommunicable diseases. Advancements in omics-based technologies and big data science offer hope for addressing NCDs, but challenges remain. These advancements may contribute to health disparities among vulnerable populations. Therefore, a new well-being-oriented system integrating all health determinants is needed to tackle NCDs and promote equitable and sustainable healthcare choices.
Article
Environmental Sciences
Abdelbaset Buhmeida, Mourad Assidi, Omar Alyazidi, Duaa Ibrahim Olwi, Ahmed Althuwaylimi, Fatimah M. Yahya, Leila Arfaoui, Leena Merdad, Adel Mohammad Abuzenadah
Summary: Healthcare providers in Saudi Arabia have limited knowledge about biobanks and are generally disinclined to actively participate in biospecimen donation and management. Factors such as job position, general health, previous blood tests, knowledge of biobanking, and attitudes toward biomedical research were found to be related to willingness to donate biospecimens.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pathology
Jaudah Al-Maghrabi, Zuhoor Al-Mansouri, Abdullah Al-Harbi, Mourad Assidi, Abdelbaset Buhmeida, Wafaey Gomaa
Summary: The study found that GPC-3 immunostaining is significantly increased in colorectal carcinoma and is associated with longer disease-free survival and overall survival. This suggests that GPC-3 may serve as an independent prognostic factor for survival in colorectal carcinoma.
POLISH JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, General & Internal
Sahar Hakamy, Mourad Assidi, Mohammad A. Jafri, Taoufik Nedjadi, Heba Alkhatabi, Abrar Al-Qahtani, Jaudah Al-Maghrabi, Khalid Sait, Mohammed Al-Qahtani, Abdelbaset Buhmeida, Adeel Chaudhary
Summary: The study demonstrates that cytoplasmic TIMP3 protein expression is not associated with age, tumor size, or lymph node involvement. However, it is significantly correlated with tumor stage and borderline significant with endpoint status. Kaplan-Meier analysis indicates a significant association between high TIMP3 expression and longer survival in OC patients.
LIBYAN JOURNAL OF MEDICINE
(2021)