4.7 Letter

Chronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey

期刊

LEUKEMIA
卷 34, 期 8, 页码 2260-2261

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/s41375-020-0904-z

关键词

-

资金

  1. Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) [Metastases 21198] Funding Source: Medline

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Hematology

Deferasirox in the management of iron overload in patients with myelofibrosis treated with ruxolitinib: The multicentre retrospective RUX-IOL study

Elena Maria Elli, Ambra Di Veroli, Daniela Bartoletti, Alessandra Iurlo, Ida Carmosino, Giulia Benevolo, Elisabetta Abruzzese, Massimiliano Bonifacio, Micaela Bergamaschi, Nicola Polverelli, Marianna Caramella, Daniela Cilloni, Mario Tiribelli, Novella Pugliese, Giovanni Caocci, Elena Crisa, Raffaele Porrini, Uros Markovic, Rossella Renso, Giuseppe Auteri, Daniele Cattaneo, Malgorzata Monika Trawinska, Luigi Scaffidi, Lucia Biale, Cristina Bucelli, Massimo Breccia, Carlo Gambacorti-Passerini, Giuseppe Alberto Palumbo, Roberto Latagliata, Francesca Palandri

Summary: The combination therapy of ruxolitinib and deferasirox provides iron chelation response and erythroid response in patients with myelofibrosis, and it is associated with improved outcome. Further clinical investigation is warranted for this treatment strategy.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Article Hematology

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report

Massimo Breccia, Elisabetta Abruzzese, Vincenzo Accurso, Immacolata Attolico, Sara Barulli, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Massimiliano Bonifacio, Giovanni Caocci, Isabella Capodanno, Fausto Castagnetti, Francesco Cavazzini, Elena Crisa, Monica Crugnola, Maria Stella De Candia, Chiara Elena, Carmen Fava, Sara Galimberti, Antonella Gozzini, Gabriele Gugliotta, Tamara Intermesoli, Alessandra Iurlo, Gaetano La Barba, Roberto Latagliata, Sabrina Leonetti Crescenzi, Luciano Levato, Giuseppina Loglisci, Alessandro Lucchesi, Luigiana Luciano, Francesca Lunghi, Debora Luzi, Alessandra Malato, Maria Cristina Miggiano, Michele Pizzuti, Patrizia Pregno, Davide Rapezzi, Giovanna Rege-Cambrin, Gianantonio Rosti, Sabina Russo, Rosaria Sancetta, Anna Rita Scortechini, Federica Sora, Paolo Sportoletti, Fabio Stagno, Agostino Tafuri, Mario Tiribelli, Robin Foa, Giuseppe Saglio

Summary: Limited information is available on the impact of the COVID-19 pandemic on the management of chronic myeloid leukaemia (CML). A retrospective study in Italy showed that during the pandemic, a majority of CML patients were infected with SARS-CoV-2, some stopped TKI therapy, and 12 patients died from COVID-19, highlighting the need for enhanced protection and management of CML patients.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Letter Oncology

BCR::ABL1 levels at first month after TKI discontinuation predict subsequent maintenance of treatment-free remission: A study from the GRUPPO TRIVENETO LMC

Sara Di Giusto, Eleonora Toffoletti, Massimiliano Bonifacio, Gianni Binotto, Maria Cristina Miggiano, Elisabetta Calistri, Manuela Stulle, Anna Ermacora, Rossella Stella, Luigi Scaffidi, Fabio D'Amore, Giorgia Scotton, Davide Griguolo, Giovanna De Matteis, Roberta Bertorelle, Mauro Krampera, Gianpietro Semenzato, Renato Fanin, Daniela Damiani, Mario Tiribelli

Summary: In this study, we analyzed the expression of BCR::ABL1 in chronic myeloid leukemia patients who discontinued imatinib or 2nd generation tyrosine kinase inhibitors (2G-TKIs) while in sustained deep molecular response. The results showed that the levels of BCR::ABL1 were higher in patients who lost major molecular response after discontinuation, and this difference became more evident after 2 months.

CANCER MEDICINE (2023)

Article Hematology

Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front-line with paediatric-inspired regimens: A retrospective multicentre Campus ALL study

Michelina Dargenio, Massimiliano Bonifacio, Sabina Chiaretti, Antonella Vitale, Nicola Stefano Fracchiolla, Cristina Papayannidis, Fabio Giglio, Prassede Salutari, Ernesta Audisio, Barbara Scappini, Patrizia Zappasodi, Marzia Defina, Fabio Forghieri, Anna Maria Scattolin, Elisabetta Todisco, Monia Lunghi, Fabio Guolo, Maria Ilaria Del Principe, Mario Annunziata, Davide Lazzarotto, Michele Cedrone, Crescenza Pasciolla, Annalisa Imovilli, Ilaria Tanasi, Silvia Trappolini, Marco Cerrano, Roberta La Starza, Mauro Krampera, Nicola Di Renzo, Anna Candoni, Giovanni Pizzolo, Felicetto Ferrara, Robin Foa

Summary: This study analyzed the incidence, characteristics, treatment, and outcome of central nervous system (CNS) relapse in adult acute lymphoblastic leukemia (ALL) patients. The study found that 6.8% of patients experienced a CNS recurrence, with a higher incidence in T-cell ALL than in B-cell ALL. Risk factors for early CNS relapse included T-cell phenotype, hyperleucocytosis, and male gender. Treatment options varied, including chemotherapy, radiotherapy, intrathecal therapy, and novel agents. Allogenic transplant after complete remission showed a significant overall survival benefit. The time to CNS relapse was the strongest predictor of post-relapse survival.

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Article Hematology

Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia

Marco Pizzi, Fabrizio Vianello, Luisa Lorenzi, Gianni Binotto, Marta Sbaraglia, Federico Scarmozzino, Andrea De Crescenzo, Vincenza Guzzardo, Simone Zoletto, Fabio d'Amore, Alberto Friziero, Mariella D'Adda, Fabio Facchetti, Angelo Paolo Dei Tos

Summary: Accessory spleens may have a significant role in immune thrombocytopenia and could contribute to relapse after splenectomy. The immune microenvironment of accessory spleens in ITP remains poorly understood. This study compared the histological features of accessory spleens and main spleens from adult patients with primary ITP, revealing similar immune events in both spleen types. These findings have implications for the mechanisms of accessory spleen-mediated ITP relapse and highlight the need for further research in spleen immunity.

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Letter Oncology

Determinants of Covid19 disease and of survival after Covid19 in MPN patients treated with ruxolitinib

Francesca Palandri, Elena M. Elli, Giuseppe Auteri, Massimiliano Bonifacio, Giulia Benevolo, Florian H. Heidel, Simona Paglia, Malgorzata M. Trawinska, Costanza Bosi, Elena Rossi, Mario Tiribelli, Alessia Tieghi, Alessandra Iurlo, Nicola Polverelli, Giovanni Caocci, Gianni Binotto, Francesco Cavazzini, Eloise Beggiato, Daniela Cilloni, Caterina Tatarelli, Francesco Mendicino, Maurizio Miglino, Monica Bocchia, Monica Crugnola, Camilla Mazzoni, Andrea D. Romagnoli, Giovanni Rindone, Sara Ceglie, Alessandra D'Addio, Eleonora Santoni, Daniele Cattaneo, Daniela Bartoletti, Roberto M. Lemoli, Mauro Krampera, Antonio Cuneo, Gianpietro C. Semenzato, Roberto Latagliata, Elisabetta Abruzzese, Nicola Vianelli, Michele Cavo, Alessandro Andriani, Valerio De Stefano, Giuseppe A. Palumbo, Massimo Breccia

BLOOD CANCER JOURNAL (2023)

Article Hematology

Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study

Darina Ocadlikova, Federico Lussana, Nicola Fracchiolla, Massimiliano Bonifacio, Lidia Santoro, Mario Delia, Sabina Chiaretti, Crescenza Pasciolla, Alessandro Cignetti, Fabio Forghieri, Francesco Grimaldi, Giulia Corradi, Letizia Zannoni, Stefania De Propris, Gian Maria Borleri, Ilaria Tanasi, Jayakumar Vadakekolathu, Sergio Rutella, Anna Rita Guarini, Robin Foa, Antonio Curti, Campus ALL

Summary: This study characterized the immune cell repertoire in the peripheral blood (PB) and bone marrow (BM) of B-cell precursor acute lymphoblastic leukaemia (B-ALL) patients treated with Blinatumomab. The results showed that Blinatumomab had different effects on PB and BM immune cell subsets, with transient changes in effector T-cell and Treg cell subsets in PB, and persistent increase in cytotoxic NK cells. Moreover, markers associated with T-cell-exhausted phenotype were modulated in BM T-cell subsets. These findings have important clinical implications in the therapeutic setting.

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Article Oncology

Patient-reported symptom monitoring and adherence to therapy in patients with newly diagnosed chronic myeloid leukemia

Fabio Efficace, Francesco Cottone, Betina Yanez, Vamsi Kota, Fausto Castagnetti, Giovanni Caocci, Massimiliano Bonifacio, Andrea Patriarca, Isabella Capodanno, Maria Cristina Miggiano, Mario Tiribelli, Massimo Breccia, Luigia Luciano, Valentina Giai, Alessandra Iurlo, Elisabetta Abruzzese, Carmen Fava, Shira Dinner, Jessica K. Altman, Gianantonio Rosti, Jorge Cortes, Marco Vignetti, David Cella

Summary: Patient-reported symptom monitoring from the beginning of therapy in patients with CML may be critical to improve adherence to therapy and early molecular response rates. The current findings suggest that systematic monitoring of patient-reported symptoms is associated with high adherence rates.

CANCER (2023)

Article Medicine, General & Internal

Italian Physicians' Perceptions about the Role of Asciminib in Later Lines Chronic Myeloid Leukemia in Clinical Practice: A GIMEMA Survey

Massimo Breccia, Alfonso Piciocchi, Elisabetta Abruzzese, Daniela Cilloni, Monica Messina, Stefano Soddu, Fausto Castagnetti, Fabio Stagno, Paola Fazi, Alessandra Iurlo, Giovanni Caocci, Antonella Gozzini, Tamara Intermesoli, Mariella DAdda, Fabrizio Pane

Summary: Unmet needs exist in later lines of chronic myeloid leukemia (CML) treatment due to poor response and overall survival in resistant patients who switch to a second-generation TKI with similar action in the second line, as well as the increase in off-target toxicities and potential mutations. However, the recent approval of asciminib, a STAMP inhibitor, in the third line could change the treatment algorithm for this patient subset. A GIMEMA survey in Italy evaluated the current number of patients receiving third-line treatment, the current approach in later lines by Italian physicians, and the perceptions about the future role of asciminib.

JOURNAL OF CLINICAL MEDICINE (2023)

Article Oncology

Predictors of Response to Hydroxyurea and Switch to Ruxolitinib in HU-Resistant Polycythaemia VERA Patients: A Real-World PV-NET Study

Francesca Palandri, Elena Rossi, Giuseppe Auteri, Massimo Breccia, Simona Paglia, Giulia Benevolo, Elena M. Elli, Francesco Cavazzini, Gianni Binotto, Alessia Tieghi, Mario Tiribelli, Florian H. Heidel, Massimiliano Bonifacio, Novella Pugliese, Giovanni Caocci, Monica Crugnola, Francesco Mendicino, Alessandra D'Addio, Simona Tomassetti, Bruno Martino, Nicola Polverelli, Sara Ceglie, Camilla Mazzoni, Rikard Mullai, Alessia Ripamonti, Bruno Garibaldi, Fabrizio Pane, Antonio Cuneo, Mauro Krampera, Gianpietro Semenzato, Roberto M. Lemoli, Nicola Vianelli, Giuseppe A. Palumbo, Alessandro Andriani, Michele Cavo, Roberto Latagliata, Valerio De Stefano

Summary: The prognostic relevance of complete response to hydroxyurea, predictors of response, and patients' triggers for switching to ruxolitinib in polycythemia vera are uncertain. Many PV patients receive underdosed hydroxyurea, leading to lower response and toxicity rates. Splenomegaly and other symptoms are the main drivers for early switch to ruxolitinib despite poor response to hydroxyurea.

CANCERS (2023)

Article Oncology

A Prognostic Model to Predict Ruxolitinib Discontinuation and Death in Patients with Myelofibrosis

Francesca Palandri, Giuseppe A. Palumbo, Massimiliano Bonifacio, Elena M. Elli, Mario Tiribelli, Giuseppe Auteri, Malgorzata M. Trawinska, Nicola Polverelli, Giulia Benevolo, Alessia Tieghi, Fabrizio Cavalca, Giovanni Caocci, Eloise Beggiato, Gianni Binotto, Francesco Cavazzini, Maurizio Miglino, Costanza Bosi, Monica Crugnola, Monica Bocchia, Bruno Martino, Novella Pugliese, Marta Venturi, Alessandro Isidori, Daniele Cattaneo, Mauro Krampera, Fabrizio Pane, Daniela Cilloni, Gianpietro Semenzato, Roberto M. Lemoli, Antonio Cuneo, Elisabetta Abruzzese, Filippo Branzanti, Nicola Vianelli, Michele Cavo, Florian Heidel, Alessandra Iurlo, Massimo Breccia

Summary: Predictors of early discontinuation of ruxolitinib therapy and death on therapy were investigated in patients with myelofibrosis. Low platelet and hemoglobin levels, primary myelofibrosis, no spleen response at 3 months, and low starting dose of ruxolitinib were associated with a higher probability of therapy failure. A predictive model was built to identify patients at higher risk of failure with ruxolitinib monotherapy, who should consider alternative frontline strategies.

CANCERS (2023)

Article Oncology

Minimal Residual Disease Detection at RNA and Leukemic Stem Cell (LSC) Levels: Comparison of RT-qPCR, d-PCR and CD26+Stem Cell Measurements in Chronic Myeloid Leukemia (CML) Patients in Deep Molecular Response (DMR)

Elisabetta Abruzzese, Monica Bocchia, Malgorzata Monika Trawinska, Donatella Raspadori, Francesco Bondanini, Anna Sicuranza, Paola Pacelli, Federica Re, Alessia Cavalleri, Mirko Farina, Michele Malagola, Domenico Russo, Paolo De Fabritiis, Simona Bernardi

Summary: The monitoring of minimal residual disease (MRD) in Chronic Myeloid Leukemia (CML) is crucial for treatment response assessment and selection of the best responders. This pilot study compared the gold standard RT-qPCR method with digital PCR and flow cytometry for MRD detection. It was found that digital PCR and flow cytometry had higher sensitivity than RT-qPCR and could detect MRD in samples previously undetectable. Additionally, low-level MRD was associated with successful treatment discontinuation.

CANCERS (2023)

Article Oncology

Blinatumomab and Inotuzumab Ozogamicin Sequential Use for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia: A Real-Life Campus All Study

Nicola Stefano Fracchiolla, Mariarita Sciume, Cristina Papayannidis, Antonella Vitale, Sabina Chiaretti, Mario Annunziata, Fabio Giglio, Prassede Salutari, Fabio Forghieri, Davide Lazzarotto, Monia Lunghi, Annalisa Imovilli, Barbara Scappini, Massimiliano Bonifacio, Michelina Dargenio, Carmela Gurrieri, Elisabetta Todisco, Marzia Defina, Maria Ilaria Del Principe, Patrizia Zappasodi, Marco Cerrano, Lidia Santoro, Elena Tagliaferri, Enrico Barozzi, Pasquale De Roberto, Marta Canzi, Elisa Buzzatti, Chiara Sartor, Francesco Passamonti, Robin Foa, Antonio Curti, Thomas Wirth

Summary: This retrospective study evaluated the efficacy and safety of blinatumomab and inotuzumab ozogamicin in the treatment of relapsed B-lymphoblastic leukemia. The study demonstrated the feasibility and effectiveness of sequential immunotherapy using these two drugs in terms of minimal residual disease, overall survival, and disease-free survival.

CANCERS (2023)

Article Oncology

Primary Myelofibrosis Occurring during Targeted Therapy for Chronic Lymphocytic Leukemia: A Report of Two Cases

Francesco Angotzi, Andrea Visentin, Federico Scarmozzino, Alessandro Cellini, Roberta Bertorelle, Marco Pizzi, Gianni Binotto, Angelo Paolo Dei Tos, Livio Trentin

Summary: The disease course of chronic lymphocytic leukemia (CLL) is frequently characterized by various complications. This report highlights the occurrence of primary myelofibrosis (PMF) in CLL patients after targeted therapy, emphasizing the need for vigilance and understanding of this co-occurrence.

CURRENT ONCOLOGY (2022)

暂无数据