PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53

PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53

(2015) Mona Sobhani et al.   CANCER BIOLOGY & THERAPY

PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance

(2014) B. Tessoulin et al.   BLOOD

Systemic treatment of soft-tissue sarcoma—gold standard and novel therapies

(2014) Mark Linch et al.   Nature Reviews Clinical Oncology

The variability of autophagy and cell death susceptibility

(2013) Ben Loos et al.   Autophagy

Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma

(2013) D N T Aryee et al.   BRITISH JOURNAL OF CANCER

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

(2013) X Peng et al.   Cell Death & Disease

Targeting Mutant p53 in Human Tumors

(2012) Brian D. Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo

(2011) Wenjie Bao et al.   CELL CYCLE

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Rare cancers are not so rare: The rare cancer burden in Europe

(2011) Gemma Gatta et al.   EUROPEAN JOURNAL OF CANCER

Constant p53 Pathway Inactivation in a Large Series of Soft Tissue Sarcomas with Complex Genetics

(2010) Gaëlle Pérot et al.   AMERICAN JOURNAL OF PATHOLOGY

Trends in survival for patients with metastatic soft-tissue sarcoma

(2010) Antoine Italiano et al.   CANCER

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis

(2009) J M R Lambert et al.   ONCOGENE

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2

(2008) J Shen et al.   ONCOGENE

PRIMA-1met radiosensitizes prostate cancer cells independent of their MTp53-status

(2008) Stéphane Supiot et al.   RADIOTHERAPY AND ONCOLOGY