Editorial Material
Urology & Nephrology
John D. Mahan, Mahmoud Kallash, William E. Smoyer
Summary: The study demonstrates the non-inferiority of a short taper for relapse of childhood NS compared to long-term treatment. It highlights the need for more well-designed studies and the use of personalized treatment for each child with idiopathic NS.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Christopher B. Pierce, Alvaro Munoz, Derek K. Ng, Bradley A. Warady, Susan L. Furth, George J. Schwartz
Summary: New glomerular filtration rate estimating equations were developed and validated for children and young adults, considering sex and age factors. Equations with age-dependent K values significantly reduced bias, especially in young children and young adults.
KIDNEY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Aftab Alam, Hala Abubaker Bagabir, Armiya Sultan, Mohd Faizan Siddiqui, Nikhat Imam, Mustfa F. Alkhanani, Ahmad Alsulimani, Shafiul Haque, Romana Ishrat
Summary: Tuberculosis (TB) is the leading cause of death from a single infectious agent, and its burden remains significant, especially in low- and middle-income countries. This study investigates the interaction between TB and noncommunicable diseases (NCDs), such as Parkinson's disease, cardiovascular disease, diabetes mellitus, rheumatoid arthritis, and lung cancer. By analyzing overlapping genes and constructing gene networks, the study identifies hub genes commonly associated with TB and its overlapping NCDs. Furthermore, a bipartite network of drugs and their targets is utilized to explore potential drug repurposing opportunities and identify side effects related to TB and its overlapping NCDs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Mirco Zerbetto, Christine Saint-Pierre, Andrea Piserchia, Simona Torrengo, Serge Gambarelli, Daniel Abergel, Antonino Polimeno, Didier Gasparutto, Giuseppe Sicoli
Summary: This study proposes an integrated approach for structural characterization of DNA tetrahedron structures. Through self-assembly and electron paramagnetic resonance spectroscopy analysis of spin-labeled DNA sequences, the study reveals the dynamic heterogeneity and flexibility of the assembled structures. This method provides unprecedented resolution in accessing the main dynamic and structural features.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Review
Urology & Nephrology
Dries Deleersnijder, Jasper Callemeyn, Ingrid Arijs, Maarten Naesens, Amaryllis H. Van Craenenbroeck, Diether Lambrechts, Ben Sprangers
Summary: Single-cell RNA sequencing and single-nucleus RNA sequencing are promising tools for understanding the pathophysiology of glomerular diseases, but face technical challenges in isolation and enrichment of glomerular cells from renal biopsy specimens.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Rhea Bhargava, Kayaho Maeda, Maria G. Tsokos, Martha Pavlakis, Isaac E. Stillman, George C. Tsokos
Summary: Transplant glomerulopathy (TG) is a major cause of late allograft loss. IgG from kidney transplant recipients with TG causes podocyte injury through CAMK4-regulated mechanisms that affect nephrin transcriptional repressor SNAIL.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Nicole Natarelli, Nimrit Gahoonia, Raja K. Sivamani
Summary: The hair cycle consists of four main phases: anagen, catagen, telogen, and exogen. Anagen is a phase characterized by hair shaft production, while catagen and telogen describe regression and resting phases of the hair follicle, ultimately resulting in hair shedding. Various factors can promote the transition from anagen to telogen, such as inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and certain medications that inhibit cell division. On the other hand, increased blood flow, direct stimulation of the hair follicle, and growth factors promote the transition from telogen to anagen and subsequent hair growth. This review comprehensively discusses the hair cycle, the balance between anagen and telogen, factors affecting the transition between these phases, and the clinical usefulness of laboratory testing and evaluations. Overall, a holistic approach is necessary to address hair loss due to the multiple factors impacting the hair cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Camille Lanaret, Dany Anglicheau, Vincent Audard, Mathias Buchler, Sophie Caillard, Lionel Couzi, Paolo Malvezzi, Laurent Mesnard, Dominique Bertrand, Franck Martinez, Vincent Pernin, Didier Ducloux, Coralie Poulain, Antoine Thierry, Arnaud Del Bello, Jean P. Rerolle, Clarisse Greze, Charlotte Uro-Coste, Julien Aniort, Celine Lambert, Nicolas Bouvier, Betoul Schvartz, Nicolas Maillard, Johnny Sayegh, Julie Oniszczuk, Marie-Pascale Morin, Christophe Legendre, Nassim Kamar, Anne E. Heng, Cyril Garrouste
Summary: The combination of RTX with SOC can improve treatment outcomes without increasing the risk of infection after kidney transplantation. RTX can be used in cases of SOC failure or remission for early discontinuation of PP.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Public, Environmental & Occupational Health
Johanna M. Vanegas, Lorena Salazar-Ospina, Gustavo E. Roncancio, J. Natalia Jimenez
Summary: This study found an association between Staphylococcus aureus colonization and bacteremia in hemodialysis patients, as well as a relationship between colonization and infection recurrence. Prompt identification of colonized patients and evaluation of decolonization protocols are essential for managing infections in this population.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Health Care Sciences & Services
Quentin Miagoux, Vidisha Singh, Dereck de Mezquita, Valerie Chaudru, Mohamed Elati, Elisabeth Petit-Teixeira, Anna Niarakis
Summary: Rheumatoid arthritis is a complex autoimmune disease with various genetic and environmental factors. By using systems biology approaches and machine learning, researchers aim to uncover mechanisms regulating key transcription factors and derive patient-specific models. Integrating multiple data types can help analyze disease heterogeneity and treatment response in a more comprehensive manner.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Leo Poelzl, Felix Naegele, Jakob Hirsch, Michael Graber, Daniela Lobenwein, Elke Kirchmair, Rosalie Huber, Christian Dorfmueller, Sophia Lechner, Georg Schaefer, Martin Hermann, Helga Fritsch, Ivan Tancevski, Michael Grimm, Johannes Holfeld, Can Gollmann-Tepekoeylue
Summary: This study demonstrates that shockwave therapy can induce regeneration of ischemic muscle in a dose-dependent manner, enhance angiogenesis, and improve limb perfusion within a therapeutic range without causing cellular damage. Provides evidence for the potential of shockwave therapy as a regenerative treatment option for ischemic cardiomyopathy.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Elke S. Schaeffner, Natalie Ebert, Martin K. Kuhlmann, Peter Martus, Nina Mielke, Alice Schneider, Markus van der Giet, Dorte Huscher
Summary: In older adults, the decline of eGFR depends on sex and age and changes only minimally after adjustment. Equations including cystatin C demonstrate a nonlinear slope, challenging the previously assumed linearity of the decline of eGFR in old age.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemical Research Methods
Wuli Xu, Lei Duan, Huiru Zheng, Jesse Li-Ling, Weipeng Jiang, Yidan Zhang, Tingting Wang, Ruiqi Qin
Summary: This study presents a disease information network-based approach called MISSION for detecting similar diseases. By integrating disease taxonomy, attributes, literature, and annotations, MISSION can effectively detect similar diseases.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
Article
Urology & Nephrology
Cynthia Delgado, Mukta Baweja, Deidra C. Crews, Nwamaka D. Eneanya, Crystal A. Gadegbeku, Lesley A. Inker, Mallika L. Mendu, W. Greg Miller, Marva M. Moxey-Mims, Glenda V. Roberts, Wendy L. St Peter, Curtis Warfield, Neil R. Powe
Summary: A Task Force developed recommendations for reassessing inclusion of race in GFR estimation in the United States. The recommendations include immediate implementation of a creatinine equation refit without the race variable and increasing the use of cystatin C, as well as encouraging research on new filtration markers and interventions to eliminate racial and ethnic disparities.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Yingnan Han, Clarence Wang, Katherine Klinger, Deepak K. Rajpal, Cheng Zhu
Summary: The study introduces a network-based approach to systematically screen and prioritize disease indications for drug targets, showing superior performance in predicting novel indications. This method has the potential to drive global indication expansion strategies by enabling rapid and systematic evaluation of individual and combined drug targets for novel indications.