Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

Disease-causing mutation in α-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch

(2018) Di Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolving Complexity of the Podocyte Cytoskeleton

(2017) Christoph Schell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting

(2017) Mukesh Kumar et al.   MOLECULAR & CELLULAR PROTEOMICS

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

Parallel reaction monitoring using quadrupole-Orbitrap mass spectrometer: Principle and applications

(2016) Adele Bourmaud et al.   PROTEOMICS

Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing

(2016) Di Feng et al.   PLoS One

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

(2015) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress in MS—classification, mechanisms and treatment

(2015) Jiwon Oh et al.   Nature Reviews Neurology

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function

(2015) Timothy Travers et al.   Science Signaling

Focal segmental glomerulosclerosis: molecular genetics and targeted therapies

(2015) Ying Maggie Chen et al.   BMC Nephrology

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

(2015) Mukund Gupta et al.   Nature Communications

The role of alpha-actinin-4 in human kidney disease

(2015) Di Feng et al.   Cell and Bioscience

Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets

(2015) Stephanie Toth-Manikowski et al.   Journal of Diabetes Research

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function

(2015) Timothy Travers et al.   Science Signaling

The Pathogenesis of Focal Segmental Glomerulosclerosis

(2014) J. Ashley Jefferson et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation

(2014) S. A. Singh et al.   EMBO JOURNAL

A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD

(2014) W. Kriz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mutations in the Gene That Encodes the F-Actin Binding Protein Anillin Cause FSGS

(2014) R. A. Gbadegesin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ACTN1 Mutations Cause Congenital Macrothrombocytopenia

(2013) Shinji Kunishima et al.   AMERICAN JOURNAL OF HUMAN GENETICS

α-Actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation

(2013) Yunfeng Feng et al.   EXPERIMENTAL CELL RESEARCH

ARHGDIA: a novel gene implicated in nephrotic syndrome

(2013) Indra Rani Gupta et al.   JOURNAL OF MEDICAL GENETICS

Fluid flow shear stress over podocytes is increased in the solitary kidney

(2013) Tarak Srivastava et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeted Proteomic Quantification on Quadrupole-Orbitrap Mass Spectrometer

(2012) Sebastien Gallien et al.   MOLECULAR & CELLULAR PROTEOMICS

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonlinear Viscoelasticity of Actin Transiently Cross-linked with Mutant α-Actinin-4

(2011) Norman Y. Yao et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

(2011) Anders S Kristensen et al.   NATURE NEUROSCIENCE

The podocyte cytoskeleton—key to a functioning glomerulus in health and disease

(2011) Gavin I. Welsh et al.   Nature Reviews Nephrology

MYO1EMutations and Childhood Familial Focal Segmental Glomerulosclerosis

(2011) Caterina Mele et al.   NEW ENGLAND JOURNAL OF MEDICINE

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Opening of tandem calponin homology domains regulates their affinity for F-actin

(2010) Vitold E Galkin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TGF-beta signal transduction in chronic kidney disease

(2009) H. et al.   Frontiers in Bioscience-Landmark

Phosphorylation of α-Actinin 4 upon Epidermal Growth Factor Exposure Regulates Its Interaction with Actin

(2009) Hanshuang Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycemia and mechanical stress: Targeting the renal podocyte

(2009) Barbara Lewko et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy

(2009) Christine Chiu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

(2009) Elizabeth J Brown et al.   NATURE GENETICS

Mice with altered α-actinin-4 expression have distinct morphologic patterns of glomerular disease

(2008) J.M. Henderson et al.   KIDNEY INTERNATIONAL

Crystal Structure of the Actin-Binding Domain of α-Actinin-4 Lys255Glu Mutant Implicated in Focal Segmental Glomerulosclerosis

(2007) Sung Haeng Lee et al.   JOURNAL OF MOLECULAR BIOLOGY