Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

(2019) Carlos M. Minutti et al.   IMMUNITY

The Role of the EGF Receptor in Sex Differences in Kidney Injury

(2019) Ming-Zhi Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proximal Tubule–Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis

(2019) Eirini Kefaloyianni et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

(2018) Xiaoping Qing et al.   JOURNAL OF CLINICAL INVESTIGATION

Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury

(2018) Qi Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN

(2018) Paul Diefenhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis

(2018) Eva Santamaría et al.   HEPATOLOGY

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

(2017) Joshua D. Ooi et al.   NATURE

A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation

(2017) Katsuhito Fujiu et al.   NATURE MEDICINE

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

(2017) Runqiu Jiang et al.   Nature Communications

Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis—Brief Report

(2017) Lynda Zeboudj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulatory T-cell–intrinsic amphiregulin is dispensable for suppressive function

(2016) Katharine Carney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis

(2016) Sihua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1

(2016) Ha Won Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR regulates macrophage activation and function in bacterial infection

(2016) Dana M. Hardbower et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN

(2016) Anna Nosko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The epidermal growth factor receptor pathway in chronic kidney diseases

(2016) Laura R. Harskamp et al.   Nature Reviews Nephrology

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+regulatory T cells to impair CD8+T-cell immunity against hepatitis B virus infection

(2015) Kai Dai et al.   IMMUNOLOGY

ROR t+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN

(2015) M. A. Kluger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN

(2015) M. Luig et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells

(2015) Chun-Hui Yuan et al.   Oncotarget

Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis

(2014) N. Lu et al.   JOURNAL OF IMMUNOLOGY

Stat3 Programs Th17-Specific Regulatory T Cells to Control GN

(2014) M. A. Kluger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

EGFR signaling in renal fibrosis

(2014) Shougang Zhuang et al.   Kidney International Supplements

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis

(2013) Malte A Kluger et al.   KIDNEY INTERNATIONAL

Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Ameliorates Collagen-Induced Arthritis

(2012) C. D. Swanson et al.   JOURNAL OF IMMUNOLOGY

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

(2011) Guillaume Bollée et al.   NATURE MEDICINE

Pro-inflammatory role of Anti-Ro/SSA autoantibodies through the activation of Furin–TACE–amphiregulin axis

(2010) Sabrina Lisi et al.   JOURNAL OF AUTOIMMUNITY

The Th17-Defining Transcription Factor ROR t Promotes Glomerulonephritis

(2010) O. M. Steinmetz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor

(2009) Tang-Cheng Lee et al.   GENESIS

The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression

(2009) Ana Pardo-Saganta et al.   JOURNAL OF HEPATOLOGY

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis

(2008) Maria J. Perugorria et al.   HEPATOLOGY

Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

(2008) Shoji Yamane et al.   Journal of Inflammation-London