期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 162, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.supflu.2020.104847
关键词
Supercritical carbon dioxide; Chrysin; Polyvinylpyrrolidone; Sub-microparticles
资金
- National Natural Science Foundation of China (NSFC) [81971734, U1605225, 31800794]
- Program for Innovative Research Team in Science and Technology in Fujian Province University
- Subsidized Project for Cultivating Postgraduates' Innovative Ability in Scientific Research of Huaqiao University
The practical application of chrysin (CHS) is significantly hindered due to its poor aqueous solubility. To address this issue, a delivery platform based on CHS-polyvinylpyrrolidone (CHS-PVP) sub-microparticles was fabricated using the supercritical antisolvent (SAS) process. Initially, the effects of different operating parameters, including temperature, CHS concentration, and acetone/ethanol ratio on the particle size of CHS-PVP sub-microparticles were validated. This eco-friendly approach resulted in spherical-shaped particles with an average particle size of 273.7 nm +/- 38.9 nm at the optimal conditions: acetone/ethanol ratio of 3:7; CHS concentration of 3 mg/mL; and temperature of 318.15 K. Further, the molecular interactions, crystallinity, drug release, and anticancer efficiency in vitro of designed particles were systematically investigated. The CHS-PVP sub-microparticles exhibited higher antiproliferative effects over pure CHS in MDA-MB-231 cells, attributing to the enhanced solubility of CHS. These findings state that the SAS process-based CHS-PVP sub-microparticles have great potential in pharmaceutical applications. (C) 2020 Elsevier B.V. All rights reserved.
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