Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mohamed Mandour, Sijia Chen, Marleen G. H. van de Sande
Summary: Spondyloarthritis (SpA) is a chronic inflammatory joint disease where the IL-23/IL-17 pathway and TNF-α cytokine play important roles in its pathogenesis. Animal models have provided new insights into molecular mechanisms at different stages of SpA, aiding in understanding disease initiation and potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Yang Jiang, Yajie Dai, Zhenquan Liu, Yan Liao, Shuyong Sun, Xianghe Kong, Jingjing Hu, Yibo Tang
Summary: Bidirectional communication between the central nervous system (CNS) and intestine is mediated by various pathways in the gut-brain axis. Disturbance in the homeostasis of intestine and gut microbiota can lead to CNS diseases, while dysbiosis of intestinal and gut microbiota can worsen the progression of CNS diseases. The IL-23/IL-17 axis has been found to play an important role in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclerosis (MS), and ischemic stroke (IS). This review focuses on the relationship between the IL-23/IL-17 axis and IS from the perspective of the gut-brain axis, aiming to provide insights for the treatment strategies of IS.
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medical Laboratory Technology
Ruth Rodriguez-Montano, Ana Guilaisne Bernard-Medina, Edith Oregon-Romero, Vianeth Maria del Carmen Martinez-Rodriguez, Maria Luisa Pita-Lopez, Belinda Claudia Gomez-Meda, Celia Guerrero-Velazquez
Summary: The study found that the expression patterns of IL-23 and IL-17A tend to be downregulated when patients have both rheumatoid arthritis and periodontitis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jiexin Wang, Linxi He, Weihong Li, Shangbin Lv
Summary: Rheumatoid arthritis (RA) is caused by joint inflammation and significantly increases the occurrence of cardiovascular disease. Mortality of RA patients with cardiovascular disease is 1.5-3 times higher than that of RA patients alone. Atherosclerosis is more prevalent and develops rapidly in RA patients, which is a major cause of death in RA. Recent studies have shown that IL-17 expression is upregulated in patients with RA and atherosclerosis, and it plays a role in the development of atherosclerosis through various ways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Christian F. Krebs, Jan-Eric Turner, Jan-Hendrik Riedel, Ulf Panzer
Summary: Immune-mediated kidney diseases are a major cause of end-stage renal disease. The immunopathogenesis of these diseases is not fully understood, leading to a lack of specific therapies. However, research has shown that cytokines related to T cell response play a crucial role in renal autoimmunity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Immunology
Hitoshi Terui, Kenshi Yamasaki, Moyuka Wada-Irimada, Mayuko Onodera-Amagai, Naokazu Hatchome, Masato Mizuashi, Riu Yamashita, Takeshi Kawabe, Naoto Ishii, Takaaki Abe, Yoshihide Asano, Setsuya Aiba
Summary: This study highlights the importance of epithelial-immune cross-talk disturbances caused by skin dysbiosis in autoimmune diseases.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)