Article
Biochemistry & Molecular Biology
Alicia Ballester, Adriana Guijarro, Beatriz Bravo, Javier Hernandez, Rodolfo Murillas, Marta Gallego, Sara Ballester
Summary: This study investigated the role of the Hedgehog (Hh) pathway in modulating the immune response. The results showed that Hh pathway activation favored the Th2 phenotype and impaired the establishment of the Th1 phenotype. Additionally, mice with constitutive activation of the Hh pathway showed a milder response to inflammatory challenge and less spinal cord damage. These findings demonstrate the involvement of the Hh/ptch pathway in immune response modulation and highlight the potential of the ptch(+/-) mouse model for studying T-cell-mediated diseases and developing new therapeutic strategies for inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Maria Concetta Geloso, Nadia D'Ambrosi
Summary: Microglia can rapidly respond to environmental changes and play a role in shaping neuronal wiring. They regulate the elimination of weaker synapses, actively participating in modulating neuronal function. Synaptic dysfunction may be an early and independent event in the neurodegenerative process associated with diseases like multiple sclerosis.
Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Rhonda R. Voskuhl, Allan MacKenzie-Graham
Summary: There are many similarities in neuropathology between MS and chronic EAE induced in C57BL/6 mice, including lesions in the spinal cord and various structures in the brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Immunology
Donghui Shen, Kang Liu, Hongyan Wang, Haifeng Wang
Summary: Autophagy plays a significant role in both protective and detrimental effects in multiple sclerosis (MS). Targeting autophagy may be a potential therapeutic approach, but further studies are needed to determine its mechanisms.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Article
Neurosciences
Yan Mi, Jinming Han, Jie Zhu, Tao Jin
Summary: PD-1/PD-L1 signaling plays a crucial role in multiple sclerosis by blocking autoimmune responses, maintaining immune tolerance, and inhibiting autoimmunity. Therefore, PD-1/PD-L1 has the potential to serve as biomarkers or therapeutic targets for multiple sclerosis.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Pathology
Sofia Rodriguez Murua, Mauricio F. Farez, Francisco J. Quintana
Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2022)
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Sofia Pereira das Neves, Joao Carlos Sousa, Nuno Sousa, Joao Jose Cerqueira, Fernanda Marques
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system that affects about 2.5 million people worldwide. There is currently no cure for MS and the available treatments only slow the initial phases of the disease. Disease progression and disability in MS are better correlated with the maintenance of a persistent low-grade inflammation inside the CNS, driven by local glial cells like astrocytes.
Article
Clinical Neurology
Hardeep Kataria, Christopher G. Hart, Arsalan Alizadeh, Michael Cossoy, Deepak K. Kaushik, Charles N. Bernstein, Ruth Ann Marrie, V. Wee Yong, Soheila Karimi-Abdolrezaee
Summary: Multiple sclerosis is characterized by immune mediated neurodegeneration, and dysregulation of neuregulin-1 beta 1 (Nrg-1 beta 1) has been associated with the pathogenesis and progression of the disease. Nrg-1 beta 1 levels are reduced in early multiple sclerosis patients, and systemic restoration of Nrg-1 beta 1 can delay symptoms and alleviate disease burden in experimental models. Nrg-1 beta 1 therapy shows promising effects in regulating immune response and may serve as a therapeutic target for ameliorating disease progression and severity.
Review
Chemistry, Multidisciplinary
Niloufar Rahiman, Marzieh Mohammadi, Seyedeh Hoda Alavizadeh, Leila Arabi, Ali Badiee, Mahmoud Reza Jaafari
Summary: Multiple Sclerosis is an autoimmune disease that can be effectively managed through the use of nanoparticles, which support early detection and therapeutic treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Takashi Kobayashi
Summary: Multiple sclerosis is an autoimmune disease characterized by immune attack on the nerve myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, expressing chemokine receptor CCR6, is crucial in determining disease activity. The role of CCL20, the ligand of CCR6, in attracting immune cells to the central nervous system (CNS) in multiple sclerosis has not been fully understood. This study generated CCL20-knockout and CCR6-knockout mice using CRISPR/Cas9 system and found that the migratory function mediated by CCL20/CCR6 may not be necessary for the onset of experimental autoimmune encephalomyelitis (EAE).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Taekyun Shin, Meejung Ahn, Jeongtae Kim, Kyungsook Jung, Changjong Moon, Moon-Doo Kim
Summary: Visual disabilities are important symptoms in central nervous system autoimmune diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Past studies have focused on neuro-inflammatory changes in the white matter of the brain, but lesions have been found in the visual pathway and retina/optic nerves. While retina and optic nerves are immunologically privileged sites, inflammation can occur via other routes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Camponeschi, Maria De Carluccio, Susanna Amadio, Maria Elisabetta Clementi, Beatrice Sampaolese, Cinzia Volonte, Maria Tredicine, Vincenzo Romano Spica, Rosa Di Liddo, Francesco Ria, Fabrizio Michetti, Gabriele Di Sante
Summary: The study demonstrated a direct correlation between S100B and inflammatory processes, and investigated the effect of AA on a mouse model of multiple sclerosis by inhibiting astrocytic S100B synthesis. The results showed that the AA-treated group had milder symptoms in the early phase of the disease and reduced various pathological features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Sachi A. Patil, Binu Joseph, Paula Tagliani, Jaume Sastre-Garriga, Xavier Montalban, Angela Vidal-Jordana, Steven L. Galetta, Laura J. Balcer, Rachel C. Kenney
Summary: This study investigated the utility and durability of optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell+inner plexiform layer (GCIPL) thickness inter-eye differences (IEDs) as markers for identifying optic nerve lesions in people with multiple sclerosis (PwMS). The results demonstrated longitudinal stability of pRNFL and GCIPL IEDs, reinforcing the role of OCT in demonstrating optic nerve lesions.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Gavin Giovannoni, Alexey Boyko, Jorge Correale, Gilles Edan, Mark S. Freedman, Xavier Montalban, Kottil Rammohan, Dusan Stefoski, Bassem Yamout, Thomas Leist, Aida Aydemir, Laszlo Borsi, Elisabetta Verdun di Cantogno
Summary: This study evaluated the long-term efficacy of cladribine tablets in patients with relapsing multiple sclerosis. The findings suggest sustained long-term mobility and disability benefits of cladribine tablets.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Marta Renom, Ingrid Galan, Xavier Vidal, Mireia Aldevert, Gemma Curto, Patricia Feliu, Itziar Garcia, Lorena Gonzalo, Xavier Sibera, Elisenda Anglada, Roger Meza, Montserrat Garcia, Victor Najas, Neus Mongay-Ochoa, Maria Jesus Arevalo, Angela Vidal-Jordana, Mar Tintore, Helena Bascunana, Xavier Montalban, Rosa Terre, Jaume Sastre-Garriga
Summary: The aim of this study was to translate and validate the Dysphagia in Multiple Sclerosis Questionnaire (DYMUS) in Spanish. The questionnaire was filled out by 100 patients with multiple sclerosis, and the results showed that the DYMUS scale is not sufficiently useful to detect dysphagia in this population. However, it can be helpful as a screening tool when combined with other measures.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Miguel Angel Robles-Sanchez, Paloma Amil-Bujan, Cristina Bosch-Farre, Claudia Coll-Martinez, Maria Jesus Arevalo, Elisenda Anglada, Rebeca Menendez, Xavier Montalban, Jaume Sastre-Garriga, Lluis Ramio-Torrenta, Carme Bertran-Noguer
Summary: This study aims to evaluate the effects of the Expert Patient Program Catalonia (EPPC-MS) on quality of life, disease-related knowledge, and self-management for people with multiple sclerosis (MS). The study uses a pre-post intervention multicenter clinical approach, involving 144 participants from 12 groups. The findings suggest that peer-led learning programs led by expert patients can empower individuals with chronic conditions and improve their autonomy and quality of life. Remote interventions offer advantages in terms of convenience and cost-saving.
FRONTIERS IN NEUROLOGY
(2023)
Correction
Clinical Neurology
Sachi A. Patil, Binu Joseph, Paula Tagliani, Jaume Sastre-Garriga, Xavier Montalban, Angela Vidal-Jordana, Steven L. Galetta, Laura J. Balcer, Rachel C. Kenney
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Luciana Midaglia, Ana Felipe-Rucian, Ignacio Delgado Alvarez, Xavier Montalban, Mar Tintore
Summary: This case report presents a 9-year-old girl with subacute symptoms of severe bilateral visual acuity decrease and gait ataxia. Features on MRI and positive anti MOG antibodies in cerebrospinal fluid (CSF) led to the diagnosis of MOG antibody disease (MOGAD) with a neuromyelitis optica spectrum disorder (NMOSD)-like picture. However, during follow-up, new lesions suggestive of pediatric-onset MS (POMS) appeared on brain MRI, leading to the restart of immunosuppressive treatment.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Llucia Coll, Deborah Pareto, Pere Carbonell-Mirabent, Alvaro Cobo-Calvo, Georgina Arrambide, Angela Vidal-Jordana, Manuel Comabella, Joaquin Castillo, Breogan Rodriguez-Acevedo, Ana Zabalza, Ingrid Galan, Luciana Midaglia, Carlos Nos, Annalaura Salerno, Cristina Auger, Manel Alberich, Jordi Rio, Jaume Sastre-Garriga, Arnau Oliver, Xavier Montalban, Alex Rovira, Mar Tintore, Xavier Llado, Carmen Tur
Summary: The application of convolutional neural networks (CNNs) to MRI data is a promising approach for accurate prediction of neurological conditions. The study of CNN-derived attention maps can uncover key disease mechanisms.
NEUROIMAGE-CLINICAL
(2023)
Review
Clinical Neurology
Oscar Fernandez, Xavier Montalban, Eduardo Aguera, Yolanda Aladro, Ana Alonso, Rafael Arroyo, Luis Brieva, Carmen Calles, Lucienne Costa-Frossard, Sara Eichau, Jose M. Garcia-Dominguez, Miguel A. Hernandez, Lamberto Landete, Miguel Llaneza, Sara Llufriu, Jose E. Meca-Lallana, Virginia Meca-Lallana, Neus Mongay-Ochoa, Ester Moral, Celia Oreja-Guevara, Lluis Ramio i Torrenta, Nieves Tellez, Lucia Romero-Pinel, Alfredo Rodriguez-Antiguedad
Summary: This article summarizes the latest developments in multiple sclerosis discussed at the 15th edition of the Post-ECTRIMS Meeting, including therapeutic strategies, definition of therapeutic failure, personalized treatment and precision medicine. It also presents the results from studies on oral cladribine and evobrutinib presented at ECTRIMS 2022.
REVISTA DE NEUROLOGIA
(2023)
Article
Clinical Neurology
Oscar Fernandez, Xavier Montalban, Eduardo Aguera, Yolanda Aladro, Ana Alonso, Rafael Arroyo, Luis Brieva, Carmen Calles, Lucienne Costa-Frossard, Sara Eichau, Jose M. Garcia-Dominguez, Miguel A. Hernandez, Lamberto Landete, Miguel Llaneza Sara Llufriu, Jose E. Meca-Lallana, Virginia Meca-Lallana, Neus Mongay-Ochoa, Ester Moral, Celia Oreja-Guevara, Lluis Ramio-Torrenta, Nieves Tellez, Lucia Romero-Pinel, Alfredo Rodriguez-Antiguedad
Summary: The 15th edition of the Post-ECTRIMS Meeting in Madrid presented the latest developments in multiple sclerosis (MS) discussed at the 2022 ECTRIMS Congress in Amsterdam. The meeting covered various aspects including the onset of MS, immune system cell migration, emerging biomarkers, imaging findings, and mechanisms of inflammation and neurodegeneration in MS pathology.
REVISTA DE NEUROLOGIA
(2023)
Meeting Abstract
Clinical Neurology
A. Bar-Or, A. H. Cross, A. Cunningham, Y. Hyvert, A. Seitzinger, E. E. Drouin, N. Alexandri, D. Tomic, X. Montalban
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Heinz Wiendl, Nicola De Stefano, Frederik Barkhof, Xavier Montalban, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Klaus Schmierer, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Elina Jarvinen, Anita Chudecka, Lidia Gardner
Meeting Abstract
Clinical Neurology
Mitzi Williams, Laura Airas, Tanuja Chitnis, Sarbjit Saini, Michihiro Hide, Gordon Sussman, Jin Nakahara, Robert Bermel, Thomas Doerner, Brett Loop, Marina Ziehn, Roman Willi, Bernd C. Kieseier, Ivan Nikolaev, Sibylle Haemmerle, Artem Zharkov, Richard Siegel, Bruno Cenni, Heinz Wiendl, Marcus Maurer, Ana Gimenez-Arnau, Xavier Montalban
Meeting Abstract
Clinical Neurology
J. Kuhle, L. Kappos, X. Montalban, P. Benkert, Y. Li, K. Thangavelu, Y. Hyvert, D. Tomic
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
D. Langdon, B. Brochet, E. K. Havrdova, J. Lechner-Scott, X. Montalban, F. Patti, F. Piehl, K. Selmaj, A. Solari, N. Alexandri, A. Nolting, A. Lehn, A. Smyk
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
Gaizka Loyola, Edwin-Roger Meza-Murillo, Carme Santoyo, Samuel Sanchez, Dolors Fabregas, Montse Janer, Pere Carbonell, Ricard Soriano Sergio Aguilar, Ingrid Galan, Augusto Sao, Jaume Sastre-Garriga, Xavier Montalban
MULTIPLE SCLEROSIS JOURNAL
(2023)
