Article
Endocrinology & Metabolism
Huawei Wang, Qing Xiong, Guangzhen He, Jun Tang, Li Sun, Siyuan Cheng, Mengting Ke, Shangyu Chen, Yong Hu, Jieyuan Feng, Linyang Song, Beier Tong, Zhengwei Zhang, Zhe Dai, Yancheng Xu
Summary: This study found that IDH2 protein levels were elevated in the livers of obese people and mice with high-fat diet consumption or hepatic steatosis. Liver IDH2-deletion mice were resistant to high-fat dietinduced body weight gain, with lower serum glucose and TG levels, increased insulin sensitivity, and higher FGF21 secretion, despite the higher TG content in the liver. Moreover, overexpression of IDH2 in hepatocytes promoted gluconeogenesis and enhanced glycogenesis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Geriatrics & Gerontology
Sichao Guo, Alexandra Wehbe, Shabber Syed, Melissa Wills, Longfei Guan, Shuyu Lv, Fengwu Li, Xiaokun Geng, Yuchuan Ding
Summary: Ischemic stroke is a common and severe condition that leads to high rates of morbidity and mortality. The endoplasmic reticulum (ER) plays a critical role in protein synthesis, trafficking, and maintaining cellular calcium homeostasis. Growing evidence suggests that ER stress contributes to the pathophysiology of stroke. In addition, decreased blood circulation to the brain after stroke impairs ATP production and leads to glucose metabolism disorder. This article discusses the relationship between ER stress and stroke, as well as the intervention and treatment of ER stress after stroke. The role of glucose metabolism, particularly glycolysis and gluconeogenesis, in post-stroke conditions is also examined. Based on recent studies, the potential interplay between glucose metabolism and ER stress is speculated. Overall, this article describes the role of ER stress, glycolysis, and gluconeogenesis in stroke and explores how their interaction contributes to the pathophysiology of the condition.
Article
Plant Sciences
Chenghong Sun, Hongbao Liang, Yun Zhao, Shirong Li, Xiangzi Li, Xiaomei Yuan, Guoliang Cheng, Yongkang Zhang, Mingfei Liu, Yongxia Guan, Jingchun Yao, Guimin Zhang
Summary: JFG effectively treats OVA/aluminum hydroxide-induced skin lesions and inflammation in mice through modulating the LKB1/AMPK/SIRT1 axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Miao Miao, Yongmei Dai, Can Rui, Yuru Fan, Xinyan Wang, Chong Fan, Juan Mu, Wenwen Hou, Zhiyong Dong, Ping Li, Guiju Sun, Xin Zeng
Summary: The study found that inulin improves glucose homeostasis during pregnancy by activating glucose transport through the translocation of GLUT4, likely mediated by decreased expression of RETN and enhanced phosphorylation of IRS and Akt.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Biochemistry & Molecular Biology
Lanqing Li, Haiying Xu, Linghang Qu, Kang Xu, Xianqiong Liu
Summary: Daidzin (DDZ), a natural compound extracted from soybean, has shown therapeutic potential against hepatocellular carcinoma cells. This study elucidates the mechanisms behind its therapeutic effects, including the regulation of proliferation and apoptosis-related genes and the influence on the glycolysis pathway.
Article
Toxicology
Evelyn Silva Moreira, Ana Paula Ames-Sibin, Carla Indianara Bonetti, Luana Eloisa Leal, Rosane Marina Peralta, Anacharis Babeto de Sa-Nakanishi, Jurandir Fernando Comar, Adelar Bracht, Livia Bracht
Summary: Berberine, a plant alkaloid, has been recognized for its antihyperglycemic properties and inhibitory effects on mitochondrial functions. This study investigated its short-term effects on hepatic metabolism using isolated perfused rat livers. The results showed that berberine modified multiple metabolic pathways, inhibiting gluconeogenesis, increasing glycolysis, impairing ammonia detoxification, and affecting energy metabolism. These findings suggest that the direct inhibitory effects of berberine on gluconeogenesis contribute significantly to its clinical efficacy as an antihyperglycemic agent. However, safety concerns arise due to the narrow margin between expected benefits and toxicity.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yue Ba, Shuo Yang, Shuiyuan Yu, Xiangbo Hou, Yuhui Du, Minghui Gao, Juan Zuo, Lei Sun, Xiaoli Fu, Zhiyuan Li, Hui Huang, Guoyu Zhou, Fangfang Yu
Summary: This study investigated the effects of fluoride intake on dental fluorosis by identifying differentially expressed proteins and metabolites. The HIF-1 and glycolysis/gluconeogenesis pathways were found to be significantly correlated with dental fluorosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Siming Wang, Yuchu Zhao, Junjie Yang, Shichao Liu, Weifeng Ni, Xueyuan Bai, Ze Yang, Daqing Zhao, Meichen Liu
Summary: This study aimed to investigate the protective effect of GPS on oxidatively damaged RBCs and explore the molecular mechanisms from the perspective of glycolysis and gluconeogenesis pathways. The results showed that GPS effectively protected RBCs from oxidative stress damage, promoted glycolysis, and regulated antioxidant defense system and energy metabolism. GPS achieved these effects by activating the PGC-1 alpha pathway and inhibiting gluconeogenesis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Salvatore Passarella, Avital Schurr, Piero Portincasa
Summary: This article discusses the role of mitochondrial transport in glycolysis and gluconeogenesis, exploring experimental methods and related mechanisms, revealing the knowledge gaps that still exist regarding the transport function of mitochondria in these two metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Sayuri Itou Da Silva, Paulo Francisco Veiga Bizerra, Marcio Shigueaki Mito, Renato Polimeni Constantin, Eduardo Makiyama Klosowski, Byanca Thais Lima De Souza, Paulo Vinicius Moreira Da Costa Menezes, Paulo Sergio Alves Bueno, Leticia Fernanda Nanami, Rogerio Marchiosi, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho, Emy Luiza Ishii-Iwamoto, Rodrigo Polimeni Constantin
Summary: The acute effects of phloretin on metabolic pathways involved in glycemia maintenance were evaluated in this study. Phloretin inhibited gluconeogenesis, stimulated glycogenolysis and glycolysis, and altered oxygen consumption. It also disrupted mitochondrial bioenergetics and decreased enzyme activity. The findings suggest that caution should be exercised when using phloretin as a therapeutic agent, particularly in long-term and high-dose treatments.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Medicine, Research & Experimental
Mangala Hegde, Uzini Devi Daimary, Sosmitha Girisa, Aviral Kumar, Ajaikumar B. Kunnumakkara
Summary: Cancer-associated cachexia (CC) is a pathological condition characterized by sarcopenia, adipose tissue depletion, and progressive weight loss. This condition is driven by various factors such as anorexia, excessive catabolism, increased energy expenditure by growing tumor mass, and inflammatory mediators. CC is associated with poor prognosis, increased mortality, and intolerance to anti-neoplastic therapy. This article discusses the spatio-temporal changes occurring in the different stages of CC, the imbalance of host metabolism, and the mechanisms that trigger and amplify the cachectic processes. Current diagnostic approaches and promising therapeutic interventions for CC are also highlighted.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ruben Rodriguez, Andrew Y. Lee, Jose A. Godoy-Lugo, Bridget Martinez, Hiroyuki Ohsaki, Daisuke Nakano, David G. Parkes, Akira Nishiyama, Jose Pablo Vazquez-Medina, Rudy M. Ortiz
Summary: The study demonstrates that chronic AT(1) blockade improves obesity-related hyperglycemia in rats by enhancing adipocyte function and reducing hepatic glucose production via gluconeogenesis. The results shed light on the therapeutic potential of chronic AT(1) blockade for hyperglycemia.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Immunology
Dan Chen, Ayinuer Aierken, Hui Li, Ruihua Chen, Lei Ren, Kai Wang
Summary: The study found that glycolysis/gluconeogenesis-related genes are associated with patient prognosis, immune microenvironment, and response to immunotherapy in HCC. The model based on five prognostic genes may be valuable for predicting the prognosis and immunotherapy response of HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Huiling Zeng, Peifeng Zhang, Hengzhen Ye, Yuxiang Ji, Christer Hogstrand, Iain Green, Juan Xiao, Qiongyao Fu, Zhiqiang Guo
Summary: This study investigated the impact of waterborne Zn exposure on the energy metabolism in orange-spotted grouper embryos. The findings showed that Zn exposure affected the expression of genes involved in glucose metabolism pathways, suggesting a developmental stage-dependent Zn uptake and genotoxicity in fish embryos. Furthermore, the study highlights the potential of fish embryos as a biosystem for evaluating cytotoxicity/genotoxicity of waterborne metals in aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2021)
Review
Urology & Nephrology
Delal Dalga, Thomas Verissimo, Sophie de Seigneux
Summary: Chronic kidney disease (CKD) is a global health issue with increasing prevalence. Understanding the alterations in metabolism during CKD, particularly in glucose production through gluconeogenesis, is important for developing new therapeutic targets. This review focuses on the metabolic changes in proximal tubular cells during CKD, including the switch from fatty acid oxidation to glycolysis and the loss of tubular gluconeogenesis. The consequences of these metabolic modifications on kidney disease, both locally and systemically, will be discussed. In addition, potential therapeutic interventions will be considered.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Parasitology
Somaditya Dey, Debarati Mukherjee, Sondipon Chakraborty, Suvadip Mallick, Aritri Dutta, Joydip Ghosh, Ningombam Swapana, Swatilekha Maiti, Narayan Ghorai, Chingakham Brajakishor Singh, Chiranjib Pal
EXPERIMENTAL PARASITOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Lokendrajit Nahakpam, Francis A. S. Chipem, Brajakishor S. Chingakham, Warjeet S. Laitonjam
NEW JOURNAL OF CHEMISTRY
(2015)
Article
Infectious Diseases
Debarati Mukherjee, Chingakham Brajakishor Singh, Somaditya Dey, Supratim Mandal, Joydip Ghosh, Suvadip Mallick, Aabid Hussain, Ningombam Swapana, Samir Anis Ross, Chiranjib Pal
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Chemistry, Organic
Lokendrajit Nahakpam, Francis A. S. Chipem, Brajakishor S. Chingakham, Warjeet S. Laitonjam
ORGANIC & BIOMOLECULAR CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Salam Pradeep Singh, Khumukcham Nongalleima, Ningthoujam Indrajit Singh, Pradip Doley, Chingakham Brajakisor Singh, Thiyam Ramsing Singh, Dinabandhu Sahoo
SCIENTIFIC REPORTS
(2018)
Article
Chemistry, Organic
Lokendrajit Nahakpam, Brajakishor S. Chingakham, Warjeet S. Laitonjam
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2015)
Article
Engineering, Environmental
Pranjal Bharali, S. Das, Angana Ray, Salam Pradeep Singh, Utpal Bora, Bolin Kumar Konwar, Chingakham Brajakishor Singh, Dinabandhu Sahoo
BIOREMEDIATION JOURNAL
(2018)
Article
Chemistry, Medicinal
Salam Pradeep Singh, Iftikar Hussain, Bolin Kumar Konwar, Ramesh Chandra Deka, Chingakham Brajakishor Singh
Summary: The study evaluated seventy phytochemicals for their ability to bind IKK-beta, identifying sesamin, matairesinol, and resveratrol as potential inhibitors with favorable binding affinity. Molecular docking, dynamics simulation, and ADME-Toxicity analysis provided insights into the mechanism of action of these plant-derived molecules for cancer treatment.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2021)
Article
Chemistry, Medicinal
Leimajam V. Chanu, Khumukcham Nongalleima, Salam P. Singh, Wahengbam K. Chanu, Chingakham B. Singh, Okram M. Singh
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Chemistry, Medicinal
Salam Pradeep Singh, Khumukcham Nongalleima, Ningthoujam Indrajit Singh, Wahengbam Kabita Chanu, Thiyam Ramsing Singh, Chingakham Brajakisor Singh
Summary: This study aimed to investigate the anti-proliferative activity of Zerumbone against cervical cancer cells and its inhibitory action on the TNF-alpha enzyme. The results suggest that Zerumbone may be a potent anti-cancer agent targeting HeLa cancer cell lines and inhibiting the TNF-alpha enzyme.
LETTERS IN DRUG DESIGN & DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Naorem Manglembi Devi, Ngasepam Bhogenjit, Henam Premananda Singh, Chingakham Brajakishor Singh, Sankaranarayanan Nagarajan
Summary: A green approach was used to fabricate quasi-spherical Ag nanoparticles from leaves and rhizomes of Alpinia Calcarata, in response to the growing demand for eco-friendly, efficient, and cost-effective antioxidant/antifungal agents. The fabricated Ag particles exhibited dose-dependent activities, with DPPH radical scavenging rates of about 69.57% and 77.1% for Ag NPs ACL and Ag NPS ACRh respectively, attributed to the simultaneous activity of surface coverage and small Ag particles. Moreover, disc-diffusion studies showed remarkable inhibitory effects of the synthesized Ag NPs ACL and Ag NPS ACRh on all tested MTCC-4878, MTCC-1811, and MTCC-7880 fungi.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Naorem Manglembi Devi, Sankaranarayanan Nagarajan, Chingakham Brajakishor Singh, Mohammad Mujahid Ali Khan, Anish Khan, Nisha Khan, Mohamed H. Mahmoud, Hassan Fouad, Abuzar Ansari
Summary: The essential oil of Alpinia calcarata demonstrated antioxidant, anti-inflammatory, and anti-diabetic activities. The oil extracted from the leaves showed slightly better results compared to the oil extracted from the rhizomes.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Mathematical & Computational Biology
Salam Pradeep Singh, Ningthoujam Indrajit Singh, Khumukcham Nongalleima, Pradip Doley, Chingakham Brajakishor Singh, Dinabandhu Sahoo
NETWORK MODELING AND ANALYSIS IN HEALTH INFORMATICS AND BIOINFORMATICS
(2018)
Article
Chemistry, Organic
Sujata D. Wangkheirakpam, Satyavama D. Asem, Wangkheirakpam Radhapiyari, Chingakham B. Singh, Rajkumar S. Yumnam, Warjeet S. Laitonjam
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
(2016)