Article
Biochemistry & Molecular Biology
Xuefeng He, Huaijun Chen, Xinyang Zhong, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Debing Shi, Dawei Li
Summary: This study found that BST2 plays a crucial role in the progression of CRC and may serve as a predictive marker for immunotherapy. Through bioinformatics analysis and experimental validation, it was shown that upregulated BST2 is associated with BRAF gene mutation, dMMR/MSI-H, CMS1 subtype, and immune response. Inhibition of BST2 can suppress CRC progression and M2 macrophage polarization.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xinying Jiang, Hailing Zhang, Hengshuo Zhang, Fan Wang, Xiaochang Wang, Tong Ding, Xuxiang Zhang, Ting Wang
Summary: This study revealed that MC-LR promotes CRC cell migration by upregulating TGF-beta 1 expression and secretion in M2 macrophages and downregulating CST3 in CRC cells. The mice in the MC-LR/AOM/DSS group showed more tumor nodules and deeper tumor invasion compared to the AOM/DSS group, indicating the importance of MC-LR in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Masanori Katagata, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Takahiro Sato, Mei Sakuma, Satoshi Fukai, Eisei Endo, Wataru Sakamoto, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Koji Kono
Summary: This study identified a close association between TIM-3 and M2-like polarization of macrophages in the TGF beta-rich tumor microenvironment, providing new insights into personalized immunotherapeutic strategies based on the tumor microenvironment for colorectal cancer.
Article
Oncology
Galateja Jordakieva, Rodolfo Bianchini, Daniel Reichhold, Jakob Piehslinger, Alina Groschopf, Sebastian A. Jensen, Ettore Mearini, Giuseppe Nocentini, Richard Crevenna, Gerhard J. Zlabinger, Sophia N. Karagiannis, Alexander Klaus, Erika Jensen-Jarolim
Summary: The study found higher levels of IgG4 in colorectal cancer patients, which can polarize macrophages into tolerogenic M2b phenotypes, shaping an immunosuppressive microenvironment. IgG4 was less effective than IgG1 in triggering antibody-dependent cell-mediated phagocytosis and higher IgG4/IgE ratios correlated with metastasis presence and poor prognostic outcomes in CRC.
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexander T. Sougiannis, Brandon VanderVeen, Ioulia Chatzistamou, Jason L. Kubinak, Mitzi Nagarkatti, Daping Fan, E. Angela Murphy
Summary: Our study confirms the effectiveness of emodin as a primary therapy against genetic and chemically induced sporadic colorectal cancer. We found that emodin reduces the number of protumorigenic M2-like macrophages in the tumor microenvironment. Furthermore, we provide evidence that emodin may be acting to antagonize the P2X7 receptor within the bone tissue, leading to decreased activation of proinflammatory cells and potentially affecting the recruitment of cells to the tumor microenvironment.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Oncology
Giuseppina Caligiuri, David A. Tuveson
Summary: Activated fibroblasts in tumors, known as cancer-associated fibroblasts (CAFs), have been a highly studied topic in the past decade. CAFs play important roles in various aspects of tumor biology, from collagen deposition to immunosuppression, and their potential as both promoters and inhibitors of tumorigenesis has been revealed through clinical and pre-clinical studies. This review discusses the crucial role of CAFs in the tumor microenvironment, the technological advances that have facilitated their investigation, and the current models available for studying CAFs. Additionally, the review highlights the need to consider CAF investigation as a promising therapeutic avenue alongside immune and cancer cells and outlines the challenges that need to be addressed for successful translation of new findings.
Review
Cell Biology
Yingjie Dong, Qiuli Yang, Ruiying Niu, Zhiyuan Zhang, Yijin Huang, Yujing Bi, Guangwei Liu
Summary: Intestinal macrophages play a crucial role in maintaining intestinal homeostasis, inflammation, and cancer development. Understanding their functions and regulatory mechanisms is of great importance for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Aung Kyi Thar Min, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Katsuharu Saito, Wataru Sakamoto, Shotaro Fujita, Hisahito Endo, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Shinji Ohki, Koji Kono
Summary: This study found that the population of M2-TAMs and VEGFR2 expression significantly increased in the tumors of CRC patients. HIF1-alpha-positive cells were significantly correlated with the VEGFR2 expression level on M2-TAMs. In vitro experiments demonstrated that M2 macrophages produced TGF-beta 1 through the VEGF/VEGFR2 signaling pathway.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jieheng Wu, Xinlei Liu, Jiangwei Wu, Chunju Lou, Qiaoling Zhang, Huiping Chen, Zeyang Yang, Shiqi Long, Yun Wang, Zhenling Shang, Zuquan Hu, Rui Zhang, Jian Zhang, Zhu Zeng
Summary: This study found that CD248-positive cancer-associated fibroblasts (CAFs) promote the progression of nonsmall cell lung cancer (NSCLC) by mediating M2-polarized macrophages. The expression of CD248 is associated with poor patient prognosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
Lauriane Onfroy-Roy, Dimitri Hamel, Laurent Malaquin, Audrey Ferrand
Summary: Colorectal cancer (CRC) is the third most common cause of cancer-related death. Patients with inflammatory bowel disease have an increased risk of CRC. The interactions between fibroblasts and ISCs in the colon may play a crucial role in the initiation of CRC due to chronic inflammation. Despite improvements in CRC treatment, including better detection and drug strategies, CRC remains a public health concern.
Article
Biochemistry & Molecular Biology
Zilu Cui, Wenkun Li, Yadan Wang, Mengran Zhao, Kuiliang Liu, Yi Yang, Shuo Teng, Nan Zhang, Li Min, Peng Li, Shutian Zhang, Junxuan Xu, Jing Wu
Summary: This study found that the protein level of ferritin heavy chain (FTH1) is upregulated in colon cancer, and M2 macrophages can deliver FTH1 through exosomes to promote colon cancer cell proliferation. These findings provide a new potential therapeutic target for the treatment of colon cancer.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Oncology
Yu Lu, Dandan Fan, Wen Wang, Xian Gao, Hanhan Li, Shuangshuang Guo, Luyang Zhao, Yaxin Guo, Bowen Li, Yali Zhong, Binglei Zhang, Jingjing Liu, Liping Dai, Qiaozhen Kang, Zhenyu Ji
Summary: The knockout of protein 4.1R reduces phagocytosis in M2 macrophages, promotes the development of colon cancer, and drives tumor progression by activating the PI3K/AKT signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Kang Geng, Xiumei Ma, Zongzhe Jiang, Junling Gu, Wei Huang, Weiming Wang, Yong Xu, Youhua Xu
Summary: This study aims to elucidate the mechanism involved in wound healing in mouse models of diabetic foot ulcer (DFU). The researchers found that WDR74 and M2 macrophages were decreased in wound tissues from DFU mice. Activation of the TGF-beta/Smad pathway increased the expression of M2 macrophage markers, IL-4, and extracellular matrix (ECM), promoting wound closure in diabetic mice. Furthermore, overexpression of WDR74 increased M2 macrophage polarization and ECM production, alleviating DFU.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
You-Ming Deng, Cheng Zhao, Lei Wu, Zhan Qu, Xin-Yu Wang
Summary: This study revealed that CB1 activation suppressed the growth and invasion of colorectal cancer by inhibiting the differentiation of M2 macrophages. These findings unveiled the potential avenue of CB1 as a targeted therapy for colorectal cancer.
CELL DEATH DISCOVERY
(2022)
Article
Infectious Diseases
Shinhye Cheon, Uni Park, Hyoree Park, Yuri Kim, Yen Thi Hai Nguyen, Abdimadiyeva Aigerim, Ji-Young Rhee, Jae-Phil Choi, Wan Beom Park, Sang Won Park, Yeonjae Kim, Dong-Gyun Lim, Jeong-Sun Yang, Joo-Yeon Lee, Yeon-Sook Kim, Nam-Hyuk Cho
Summary: The study found that the seropositivity rate of recovered MERS patients persisted for a longer duration, while neutralizing antibody titres decreased more rapidly. Patients with severe pneumonia had higher seropositivity rates and longer duration of neutralizing antibody titres.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Nutrition & Dietetics
Marcela D. Radtke, Mykaela Poe, Jodi Stookey, Stephanie Jilcott Pitts, Nancy E. Moran, Matthew J. Landry, Lewis P. Rubin, Virginia C. Stage, Rachel E. Scherr
Summary: Carotenoids are commonly used as a biomarker for fruit and vegetable intake, with the Veggie Meter (R) being a noninvasive instrument that can detect and quantify carotenoids in the skin. A protocol was developed with users of the Veggie Meter (R) to standardize preparation, calibration, and data collection procedures for research purposes. The ultimate goal is to establish a universal data repository to examine the associations between skin carotenoid scores and diet-related health outcomes.
CURRENT DEVELOPMENTS IN NUTRITION
(2021)
Article
Medicine, General & Internal
Pyoeng Gyun Choe, Yuri Kim, Euijin Chang, Chang Kyung Kang, Nam Joong Kim, Nam-Hyuk Cho, Wan Beom Park, Myoung-don Oh
Summary: Neutralizing antibody responses to the delta variant were detectable in patients with severe disease, but at lower levels compared to the wild type. However, these responses were undetectable in asymptomatic individuals. Vaccination strategies for individuals with previous natural infection should be based on the severity of their previous infection.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Seung-Wan Choi, Hyun-Min Kim, Suk-Young Yoon, Dae-Yeon Jo, Sun-Kyo Kim, Yuri Kim, Seong Min Park, Young-Ju Lee, Heesun Yang
Summary: In this research, high-quality indium phosphide quantum dots were synthesized using safer aminophosphine precursors, and the emissivity of red InP QDs was enhanced by adopting unconventional In precursor InBr3 instead of InCl3. Improvements in the emissivity of red InP QDs towards deeper, narrower spectra were achieved by thickening the ZnSe inner shell.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Review
Oncology
Sakshi Jhawar, Yasuhiro Arakawa, Suresh Kumar, Diana Varghese, Yoo Sun Kim, Nitin Roper, Fathi Elloumi, Yves Pommier, Karel Pacak, Jaydira Del Rivero
Summary: Pheochromocytomas and paragangliomas are rare neuroendocrine tumors, and approximately 40% of cases are associated with genetic mutations. These mutations can influence the clinical presentation, prognosis, and follow-up of patients. Genetic testing allows for early detection of hereditary syndromes and close monitoring of high-risk patients.
Article
Chemistry, Multidisciplinary
Yuri Kim, Hee Joon Jung, Yunjung Lee, Sagang Koo, Ramar Thangam, Woo Young Jang, Seong Yeol Kim, Sangwoo Park, Sungkyu Lee, Gunhyu Bae, Kapil Dev Patel, Qiang Wei, Ki-Bum Lee, Ramasamy Paulmurugan, Woong Kyo Jeong, Taeghwan Hyeon, Dokyoon Kim, Heemin Kang
Summary: In this study, the modulation of receptor-ligand interactions in cells using magnetic nanoparticle aggregates is investigated. Manipulating the accessible ligand dispersity can either promote macrophage adhesion and healing or suppress it depending on the ligand accessibility. This study presents accessible ligand dispersity as a novel parameter that regulates receptor-ligand binding and polarization of macrophages.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nutrition & Dietetics
Jonghee Kim, Joanne F. Dorgan, Hyesook Kim, Oran Kwon, Yangha Kim, Yuri Kim, Kwang Suk Ko, Yoon Jung Park, Hyesook Park, Seungyoun Jung
Summary: The use of nutrition labels is associated with a lower risk of chronic kidney disease, especially in older adults.
Article
Multidisciplinary Sciences
Jihwan Chae, Kunil Kim, Yuri Kim, Gahyun Lim, Daeeun Kim, Hackjin Kim
Summary: Limited resources can modulate individuals' decisions in intergroup situations by affecting ingroup favoritism and fairness. Participants were more willing to accept proposals in the ingroup advantageous condition and in moderate inequality conditions. However, individuals showed marked differences in their preferences for ingroup favoritism or fairness.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Taeseob Lee, Yuri Kim, Hyun Je Kim, Na-Young Ha, Siyoung Lee, BumSik Chin, Nam-Hyuk Cho
Summary: By using single-cell RNA sequencing analysis, this study found that B-cell response and humoral immunity play an important role in the progression and severity of COVID-19. Severe cases showed a more robust and heterogeneous plasma cell response, with the emergence of an abnormal plasma cell subset. This subset exhibited higher inflammatory features and may be a critical driver of disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Lorinc Sandor Pongor, Christopher W. Schultz, Lorenzo Rinaldi, Darawalee Wangsa, Christophe E. Redon, Nobuyuki Takahashi, Gavriel Fialkoff, Parth Desai, Yang Zhang, Sandra Burkett, Nadav Hermoni, Noa Vilk, Jenia Gutin, Rona Gergely, Yongmei Zhao, Samantha Nichols, Rasa Vilimas, Linda Sciuto, Chante Graham, Juan Manuel Caravaca, Sevilay Turan, Tsai-wei Shen, Vinodh N. Rajapakse, Rajesh Kumar, Deep Upadhyay, Suresh Kumar, Yoo Sun Kim, Nitin Roper, Bao Tran, Stephen M. Hewitt, David E. Kleiner, Mirit I. Aladjem, Nir Friedman, Gordon L. Hager, Yves Pommier, Thomas Ried, Anish Thomas
Summary: In this study, it was found that ecDNA is the primary source of gene amplifications and fusions in small-cell lung cancer (SCLC), leading to transcriptional amplification and high heterogeneity of the tumor. Furthermore, cell-free nucleosome profiling can noninvasively detect ecDNA amplifications, facilitating genome-wide investigation in SCLC and other cancers.
Article
Food Science & Technology
Yeri Kim, Hyejin Han, Yeonsoo Oh, Hakdong Shin, Gwoncheol Park, Sunghee Park, John A. Manthey, Yang Kim, Yuri Kim
Summary: The study found that supplementation with Reb A and NHDC can effectively reduce weight gain, food efficiency ratio, and fat mass. Additionally, gene expressions related to adipogenesis, lipogenesis, and lipolysis were reduced, while beta-oxidation related genes were upregulated in the liver. Furthermore, the supplementation also caused changes in the gut microbiota structure.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Immunology
Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim, Hee-Yong Kim
Summary: This study aimed to determine the effects of single-dose acute ethanol exposure and GPR110 activation on neuroinflammation mechanisms. The results showed that single-dose ethanol exposure exacerbated LPS-induced inflammatory responses, while the GPR110 ligand synaptamide mitigated the effects of ethanol by counteracting the cAMP system and regulating the NLRP3 inflammasome.
JOURNAL OF NEUROINFLAMMATION
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Yuri Kim, Chaeyeon Lee, Jihyun Choi, Seoyeon Oh, Seongbin Park
Summary: This research introduces a project on designing course materials for an introduction to programming using the functional programming language Clean. Clean is believed to be a better choice for students due to its simple syntax and smaller program size compared to procedural languages. Introducing Clean in the course allows for intuitive introduction of recursive examples, which helps students understand this important concept.
PROCEEDINGS OF THE 2023 CONFERENCE ON INNOVATION AND TECHNOLOGY IN COMPUTER SCIENCE EDUCATION, ITICSE 2023, VOL. 2
(2023)
Article
Chemistry, Multidisciplinary
Minki Kang, Na-Yoon Jang, Young-Jun Kim, Hyo-Jin Ro, Dabin Kim, Yuri Kim, Hyoung Taek Kim, Hye Mi Kwon, Jin-Hyun Ahn, Byung-Ok Choi, Nam-Hyuk Cho, Sang-Woo Kim
Summary: This study demonstrates a virus-blocking textile (VBT) that repulses SARS-CoV-2 by utilizing repulsive Coulomb force and triboelectric energy harvesting. The VBT can effectively block SARS-CoV-2 by 99.95% and reduce the presence of the virus within the textile by 13-fold.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Kyung Eun Lee, Minseo Kwon, Yoo Sun Kim, Yerin Kim, Min Gi Chung, Seung Chul Heo, Yuri Kim
Summary: The study showed that beta-carotene has inhibitory effects on colon cancer stem cells, reducing tumor number and size while delaying tumor onset.
NUTRITION RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
