Article
Geriatrics & Gerontology
Calum A. Hamilton, James Frith, Paul C. Donaghy, Sally A. H. Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Louise M. Allan, John O'Brien, Alison J. Yarnall, Alan J. Thomas
Summary: The study aimed to compare the blood pressure and heart rate responses of probable MCI-LB and MCI-AD patients to orthostatic challenge and Valsalva manoeuvre. The findings indicate that abnormal blood pressure response to Valsalva may be more common in probable MCI-LB, while orthostatic hypotension is not a clear distinguishing feature between MCI-AD and MCI-LB.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Peripheral Vascular Disease
Ryota Tanaka, Nobutaka Hattori
Summary: Disruption of circadian blood pressure rhythm is associated with cognitive impairment in neurodegenerative disorders like alpha-synucleinopathies. Orthostatic hypotension, supine hypertension, and abnormal nocturnal blood pressure fall may contribute to cognitive impairment in these diseases.
HYPERTENSION RESEARCH
(2022)
Review
Clinical Neurology
Debora Loureiro, Rodrigo Bilbao, Sofia Bordet, Lina Grasso, Matilde Otero-Losada, Francisco Capani, Osvaldo J. J. Ponzo, Santiago Perez-Lloret
Summary: Orthostatic hypotension is significantly associated with minimal cognitive impairment and dementia in patients with Parkinson's disease, especially in women and those without hypertension.
NEUROLOGICAL SCIENCES
(2023)
Review
Multidisciplinary Sciences
Isaac Saywell, Brittany Child, Lauren Foreman, Lyndsey Collins-Praino, Irina Baetu
Summary: Cognitive reserve is being studied to understand its predictive effects on cognitive and motor outcomes for patients with alpha-synucleinopathies. This review protocol follows accepted guidelines and aims to analyze a wide range of studies investigating this association. The findings could have significant implications for preventive interventions and treatment strategies in the wider population.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Peripheral Vascular Disease
Xin Xia, Rui Wang, Davide L. Vetrano, Giulia Grande, Erika J. Laukka, Mozhu Ding, Laura Fratiglioni, Chengxuan Qiu
Summary: Orthostatic hypotension (OH) is associated with an increased risk of dementia and accelerated progression from cognitive impairment to dementia in older adults.
Article
Behavioral Sciences
Ohnmar Hsam, Zacharias Kohl
Summary: Dysfunction of the serotonergic system is a significant characteristic in synucleinopathies, such as Parkinson disease, dementia with Lewy bodies, and Multiple system atrophy. Studies have shown that alterations in the serotonergic system are associated with non-motor symptoms, motor complications, and autonomic features of these diseases. Postmortem studies, animal models, and imaging techniques have contributed to understanding the pathophysiology of the serotonergic system, leading to potential drug targets. This review summarizes recent work that expands the knowledge of the serotonergic system and its relevance to synucleinopathies' pathophysiology.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Hongxiu Chen, Erhe Xu, Fubo Zhou, Qiuping Li, Jingrong Zeng, Shanshan Mei, Yingqi Xing
Summary: This study investigated the association between impaired dynamic cerebral autoregulation (dCA) and orthostatic hypotension (OH) and Parkinson's disease dementia (PDD). The results suggest that diminished dCA may contribute to OH and cognitive impairment in PD patients, and low educational level might increase the risk of PDD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sebastian Johannes Mueller, Eya Khadhraoui, Niels Hansen, Ala Jamous, Philip Langer, Jens Wiltfang, Christian Heiner Riedel, Caroline Bouter, Christoph van Riesen, Fabian Maass, Michael Bartl, Claudia Lange, Marielle Ernst
Summary: DLB remains underdiagnosed compared with AD and PD due to overlapping clinical symptoms. This study focuses on brainstem characteristics to differentiate DLB from PSP and PD.
Article
Clinical Neurology
Xiaofan Xue, Anqi Huang, Jingrong Zeng, Haixia Song, Yingqi Xing, Piu Chan, Erhe Xu, Lichun Zhou
Summary: Patients with Parkinson's disease (PD) accompanied by orthostatic hypotension (OH) exhibit poor memory function, possibly due to decreased metabolic function in specific medial temporal lobes and impaired dynamic cerebral autoregulation ability.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Morgane Linard, Alix Ravier, Louisa Mougue, Iris Grgurina, Anne-Laurence Boutillier, Alexandra Foubert-Samier, Frederic Blanc, Catherine Helmer
Summary: This article reviews the ongoing research on the role of infectious agents in the onset of alpha-synucleinopathies, discussing factors such as the potential antimicrobial role of alpha-synuclein, entry points of pathogens, and the associations between infectious agents and different diseases.
MOVEMENT DISORDERS
(2022)
Review
Neurosciences
Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross, Dennis W. Dickson
Summary: Synucleinopathies are a group of diseases characterized by pathological aggregates of alpha-synuclein in neurons and glia. The two main disease entities are Lewy body disease and multiple system atrophy, each with different clinical subtypes. Currently, there are no disease-modifying therapies, but research on molecular mechanisms provides hope for future treatments.
MOLECULAR NEURODEGENERATION
(2021)
Article
Clinical Neurology
Katherine Longardner, Aristide Merola, Irene Litvan, Alberto Maria De Stefano, Simona Maule, Fabrizio Vallelonga, Leonardo Lopiano, Alberto Romagnolo
Summary: Cardiovascular dysautonomia was associated with a sevenfold higher risk of developing dementia and a fivefold higher risk of falls in PD patients, as well as significantly higher impairment in ADLs and HRQoL. No relevant associations were found between the other autonomic domains and these outcomes.
JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noah J. Graves, Yann Gambin, Emma Sierecki
Summary: Like many neurodegenerative diseases, Parkinson's disease (PD) is characterized by the formation of proteinaceous aggregates in brain cells. Additionally, these aggregates are also found in other disorders, collectively referred to as synucleinopathies. Despite the diversity in pathologies and symptoms, aSyn aggregates are a common marker and potential driver of these diseases. This review compares PD, DLB, and MSA, highlighting the role of aSyn aggregates in each disorder and discussing the relationship between aSyn strains and the cellular environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yueh-Sheng Chen, Hsiu-Ling Chen, Cheng-Hsien Lu, Chih-Ying Lee, Kun-Hsien Chou, Meng-Hsiang Chen, Chiun-Chieh Yu, Yun-Ru Lai, Pi-Ling Chiang, Wei-Che Lin
Summary: This study investigated the association between structural covariance networks (SCNs) and cognitive impairment in Parkinson's disease (PD) patients. Results showed that cognitive impairment in PD is linked to degeneration of the amygdala/hippocampus SCN, with dementia patients exhibiting increased covariance over the prefrontal cortex. PD patients with normal cognition who later developed cognitive impairment showed decreased gray matter volume of the amygdala/hippocampus SCN in initial MRI scans. These findings suggest a neural network-based mechanism for cognitive decline in PD patients and highlight the potential of SCN analysis in predicting cognitive decline.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Harald Hampel, Andrea Vergallo, Filippo Caraci, A. Claudio Cuello, Pablo Lemercier, Bruno Vellas, Kelly Virecoulon Giudici, Filippo Baldacci, Britta Hanisch, Marion Haberkamp, Karl Broich, Robert Nistico, Enzo Emanuele, Francisco Llavero, Jose L. Zugaza, Alejandro Lucia, Ezio Giacobini, Simone Lista
Summary: The availability of disease-modifying therapies for Alzheimer's disease will lead to a large demand for clinical and biological screening, challenging global healthcare systems. Advancements are needed in validating and qualifying minimally-invasive blood-based biomarkers to align with an evolving ATN + classification system. Novel pathophysiological mechanisms and candidate biomarkers are being integrated into blood-based liquid biopsies to drive precision medicine strategies.
Article
Clinical Neurology
Eleonora Del Prete, Alessio Francesconi, Giovanni Palermo, Sonia Mazzucchi, Daniela Frosini, Riccardo Morganti, Piero Coleschi, Laura Maria Raglione, Paola Vanni, Silvia Ramat, Alessio Novelli, Alessandro Napolitano, Carla Battisti, Martina Giuntini, Carlo Rossi, Chiara Menichetti, Monica Ulivelli, Valentino De Franco, Simone Rossi, Ubaldo Bonuccelli, Roberto Ceravolo
Summary: The study found a higher prevalence of COVID-19 in the PD population compared to in Tuscany and Italy. PD patients did not experience a subjective worsening of symptoms during the lockdown period, and they were also favorable to telemedicine, although there was reduced availability to perform it.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Eleonora Del Prete, Luca Tommasini, Sonia Mazzucchi, Daniela Frosini, Giovanni Palermo, Riccardo Morganti, Cristina Pagni, Gloria Tognoni, Ubaldo Bonuccelli, Roberto Ceravolo
Summary: This study aimed to investigate the language profile, especially connected speech, in early-stage PSP-RS and PD patients. The results showed that PSP-RS patients exhibited significant impairment in language domain, particularly in connected speech, compared to PD. Furthermore, the number of sentences and subordinates in the picture description task were identified as predictors of PSP diagnosis.
NEUROLOGICAL SCIENCES
(2021)
Meeting Abstract
Clinical Neurology
Giovanni Palermo
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Letter
Clinical Neurology
Giovanni Palermo, Daniela Frosini, Angelo Antonini, Roberto Ceravolo
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Eleonora Del Prete, Emmanuelle Schmitt, Sara Meoni, Valerie Fraix, Anna Castrioto, Pierre Pelissier, Roberto Ceravolo, Elena Moro
Summary: This study investigates the relationship between motor fluctuations (MFs) and neuropsychiatric fluctuations (NMFs) in Parkinson's disease (PD). The findings suggest that NMFs only temporarily match the OFF MFs in PD patients. The study emphasizes the need to further investigate the associations between non-motor and motor symptoms in PD patients to better manage NMFs.
NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Linda Giampietri, Elisabetta Belli, Maria Francesca Beatino, Sara Giannoni, Giovanni Palermo, Nicole Campese, Gloria Tognoni, Gabriele Siciliano, Roberto Ceravolo, Ciro De Luca, Filippo Baldacci
Summary: The diagnosis of neurodegenerative diseases is a growing social burden, and the failure of current disease-modifying therapies calls for a different approach in drug design and patient selection. The development of novel biomarkers, particularly fluid biomarkers, can improve the diagnosis, prognosis, and clinical trials of neurodegenerative diseases.
Article
Clinical Neurology
Sonia Mazzucchi, Eleonora Del Prete, Mauro Costagli, Daniela Frosini, Davide Paoli, Gianmichele Migaleddu, Paolo Cecchi, Graziella Donatelli, Riccardo Morganti, Gabriele Siciliano, Mirco Cosottini, Roberto Ceravolo
Summary: This study evaluated the diagnostic potential of a multimodal MRI protocol combining morphometric and quantitative susceptibility mapping (QSM) imaging in patients with determined parkinsonisms. The results showed that QSM had excellent diagnostic accuracy in distinguishing PD from PSP and good accuracy in distinguishing PD from MSA-p. Combining morphometric imaging and QSM could improve the diagnostic phase of degenerative parkinsonisms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesco Cavallieri, Valentina Fioravanti, Francesco Bove, Eleonora Del Prete, Sara Meoni, Sara Grisanti, Marialuisa Zedde, Rosario Pascarella, Elena Moro, Franco Valzania
Summary: This review summarizes the clinical, biological, and neuroimaging features of COVID-19-related parkinsonism and discusses the possible pathophysiological mechanisms. The appearance of parkinsonism during or immediately after COVID-19 infection is a very rare event. Different mechanisms, including vascular damage and neuroinflammation, may play a role, and further long-term observational studies are needed to evaluate the association between COVID-19 infection and the development of Parkinson's Disease.
Article
Psychology, Clinical
L. Tommasini, J. Bonaccorsi, E. Del Prete, S. Cintoli, C. Pagni, S. Mazzucchi, G. Palermo, R. Morganti, D. Frosini, G. Siciliano, G. Tognoni, R. Ceravolo
Summary: This study explored the role of neuropsychological markers in differentiating between Parkinson's Disease and Progressive Supranuclear Palsy. It found that specific qualitative scoring systems were useful in distinguishing between the two diseases, and proposed a regression model with high diagnostic accuracy.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Editorial Material
Clinical Neurology
Giovanni Palermo, Roberto Ceravolo
MOVEMENT DISORDERS
(2023)
Editorial Material
Clinical Neurology
Giovanni Palermo, Alessio Di Fonzo, Alessio Francesconi, Elisa Unti, Roberto Ceravolo
NEUROLOGICAL SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
G. Palermo, S. Giannoni, M. Giuntini, E. Belli, D. Frosini, G. Siciliano, R. Ceravolo
MOVEMENT DISORDERS
(2021)