Article
Virology
Yuan Cheng, Jing Ma, He Wang, Xi Wang, Zhanwei Hu, Haichao Li, Hong Zhang, Xinmin Liu
Summary: A study analyzed data from 213 COVID-19 patients treated at Tongji Hospital in Wuhan from January 28, 2020 to March 24, 2020, revealing that 45.5% of patients tested positive for influenza A virus (IFV-A). Patients with co-infection showed similar clinical patterns to those with SARS-CoV-2 infection only, but higher levels of inflammatory markers and cardiac injury were observed in the latter group.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Minjun Ni, Hengyi Xu, Jie Luo, Wei Liu, Donggen Zhou
Summary: A novel quadruplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assay was developed for the simultaneous detection and differentiation of SARS-CoV-2 genes, hIAV and hIBV, showing good sensitivity, specificity, and clinical performance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Cynthia Y. Tang, Maria Boftsi, Lindsay Staudt, Jane A. McElroy, Tao Li, Sabrina Duong, Adrienne Ohler, Detlef Ritter, Richard Hammer, Jun Hang, Xiu-Feng Wan
Summary: This study investigated the co-infection of SARS-CoV-2 and influenza viruses during the 2021-2022 influenza season. The results showed a high prevalence of co-infections in central Missouri, with differences in co-infection rates between the Delta and Omicron waves, and the importance of influenza vaccines in reducing co-infections.
Article
Immunology
Weizheng Liang, Xiushen Li, Hao Wang, Kechao Nie, Qingxue Meng, Junli He, Chunfu Zheng
Summary: This study investigates the mechanism of puerarin in the treatment of patients with EHF/SARS-CoV-2 using network pharmacology and bioinformatics. The results suggest that puerarin may reduce excessive immune responses and inflammation through the regulation of NF-B, TNF, and HIF-1 signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hossam Waleed Almadhoon, Aboalmagd Hamdallah, Sarah Makram Elsayed, Abdulrahman Ibrahim Hagrass, Mohammed Tarek Hasan, Aya Mamdouh Fayoud, Mohammed Al-Kafarna, Mohammad Elbahnasawy, Fadel Alqatati, Khaled Mohamed Ragab, Mohamed Sayed Zaazouee, Elfatih A. Hasabo
Summary: Recent evidence suggests that influenza vaccination may reduce the clinical outcomes of COVID-19. The study found a significant reduction in the risk of mechanical ventilation for COVID-19 patients who received the influenza vaccine. However, there were no statistically significant differences in mortality rate, hospital admissions, and intensive care admissions between vaccinated and non-vaccinated groups. Further research is encouraged due to limitations in the data and the regular updates of the influenza vaccine.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Hye Kwon Kim, Jung-Ah Kang, Kwang-Soo Lyoo, Tran Bac Le, Yoon Hwan Yeo, Sook-San Wong, Woonsung Na, Daesub Song, Richard J. Webby, Mark Zanin, Dae Gwin Jeong, Sun-Woo Yoon
Summary: In a Syrian hamster co-infection model, co-infection with SARS-CoV-2 and influenza virus resulted in more severe disease, altered hematological changes, and changed influenza virus tissue tropism in the respiratory tract compared to infection with either virus alone.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Giacomo Guido, Eleonora Lalle, Silvia Mosti, Paola Mencarini, Daniele Lapa, Raffaella Libertone, Stefania Ianniello, Giulio Maria Ricciuto, Francesco Vaia, Fabrizio Maggi, Fabrizio Palmieri
Summary: The ECDC assesses the overall probability of infection with RSV, influenza virus, or SARS-CoV-2 in the general population as high. High circulation of respiratory viruses leads to increased hospitalizations and significant pressure on healthcare systems. In this article, we describe a case of a 52-year-old woman who recovered from pneumonia with a triple infection of SARS-CoV-2, RSV, and influenza virus. We suggest searching for antigenic or molecular detection of RSV and influenza viruses, along with SARS-CoV-2, in patients with respiratory symptoms during this epidemic period, as all three viruses are currently present.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
Hamidreza Abbasi, Hadi Razavi Nikoo, Fatemeh Fotouhi, Ayyoob Khosravi
Summary: A novel in-house made multiplex RT-qPCR assay was developed in this study, showing high sensitivity, specificity, and reliability for the diagnosis of SARS-CoV-2 infection in clinical samples. This assay is valuable during Influenza seasons when influenza co-circulates with SARS-CoV-2, as it saves costs, time, and ensures specific and timely treatment of patients.
Article
Biology
Matthieu Domenech de Celles, Elizabeth Goult, Jean-Sebastien Casalegno, Sarah C. Kramer
Summary: There is growing evidence that respiratory viruses, including influenza and SARS-CoV-2, can interact and their epidemiological dynamics are not independent. Earlier studies used co-detection prevalence data to assess these interactions, but our research suggests that this method is not reliable. It underestimates the strength of interactions and may misclassify antagonistic or synergistic interactions.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ryuta Uraki, Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda, Peter J. Halfmann, Samantha Loeber, Tadashi Maemura, Seiya Yamayoshi, Seiichiro Fujisaki, Zhongde Wang, Mutsumi Ito, Michiko Ujie, Kiyoko Iwatsuki-Horimoto, Yuri Furusawa, Ryan Wright, Zhenlu Chong, Seiya Ozono, Atsuhiro Yasuhara, Hiroshi Ueki, Yuko Sakai-Tagawa, Rong Li, Yanan Liu, Deanna Larson, Michiko Koga, Takeya Tsutsumi, Eisuke Adachi, Makoto Saito, Shinya Yamamoto, Masao Hagihara, Keiko Mitamura, Tetsuro Sato, Masayuki Hojo, Shin-ichiro Hattori, Kenji Maeda, Riccardo Valdez, Moe Okuda, Jurika Murakami, Calvin Duong, Sucheta Godbole, Daniel C. Douek, Ken Maeda, Shinji Watanabe, Aubree Gordon, Norio Ohmagari, Hiroshi Yotsuyanagi, Michael S. Diamond, Hideki Hasegawa, Hiroaki Mitsuya, Tadaki Suzuki, Yoshihiro Kawaoka
Summary: The replicative ability and pathogenicity of Omicron BA.2 variant is similar to that of BA.1 in rodents, but it shows less pathogenicity compared to early SARS-CoV-2 strains. There is a marked reduction in the neutralizing activity of plasma from individuals who had recovered from COVID-19 and vaccine recipients against BA.2 variant.
Article
Infectious Diseases
Pontus Hedberg, Niclas Johansson, Anders Ternhag, Lina Abdel-Halim, Jonas Hedlund, Pontus Naucler
Summary: A lower prevalence of bacterial co-infections was observed in patients with community-acquired SARS-CoV-2 positive pneumonia compared to those with influenza and RSV positive pneumonia.
BMC INFECTIOUS DISEASES
(2022)
Article
Virology
Neeraj Aggarwal, Varsha Potdar, Neetu Vijay, Labanya Mukhopadhyay, Biswajyoti Borkakoty, S. Manjusree, Manohar Lal Choudhary, Deepika Chowdhury, Riya Verma, Sumit Dutt Bhardwaj, Neelanjana Sarmah, K. H. Sreelatha, Prabhat Kumar, Nivedita Gupta
Summary: This study reports cases of SARS-CoV-2/influenza virus co-infection from both community and hospital settings in India, using the integrated ILI/SARI surveillance system. The findings show that influenza viruses are circulating in the community even during COVID-19, emphasizing the need for continuous surveillance of multiple respiratory pathogens.
Article
Microbiology
Nicolas Malausse, Sylvie van der Werf, Nadia Naffakh, Sandie Munier
Summary: Co-infections between influenza A virus (IAV) and influenza B virus (IBV) were studied by infecting A549 cells with recombinant IAV-GFP and IBV-mCherry. Surprisingly, IBV replication was enhanced when co-infected with IAV, particularly when IAV was added 1 hour before IBV. This enhancing effect was dependent on transcription/replication of the IAV genome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Maxwell D. Weidmann, Daniel A. Green, Gregory J. Berry, Fann Wu
Summary: In 2022, respiratory viruses such as influenza and RSV experienced a significant resurgence in the Northeast US, resulting in a rise in viral co-infections. However, the co-infection rates of seasonal respiratory viruses during this period have not been assessed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Kyle R. Rizzo, Cora Hoover, Seema Jain, Monica Sun, Jennifer F. Myers, Brooke Bregman, Deniz M. Dominguez, Allison Jacobsen, Garrett J. Jenkins, Tamara Hennessy-Burt, Erin L. Murray
Summary: During September 1, 2020-April 30, 2021, California experienced minimal influenza activity with sporadic co-infections.
EMERGING INFECTIOUS DISEASES
(2021)
