Article
Virology
Nilgun Duman, Gulten Tuncel, Atil Bisgin, Sevcan Tug Bozdogan, Sebnem Ozemri Sag, Seref Gul, Aslihan Kiraz, Burhan Balta, Murat Erdogan, Bulent Uyanik, Sezin Canbek, Pinar Ata, Bilgen Bilge Geckinli, Esra Arslan Ates, Ceren Alavanda, Sevda Yesim Ozdemir, Ozlem Sezer, Gulay Oner Ozgon, Hakan Gurkan, Kubra Guler, Ibrahim Boga, Niyazi Kaya, Adem Alemdar, Murat Sayan, Munis Dundar, Mahmut Cerkez Ergoren, Sehime Gulsun Temel
Summary: This study conducted a retrospective comparative genome analysis of ACE2 and TMPRSS2 gene variants in a Turkish population. The main ACE2 variants related to SARS-CoV-2 infection have not yet been identified, while TMPRSS2 rs75603675 and rs12329760 variants showed different allele frequencies in the population.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Stefania Damiani, Michelangelo Fiorentino, Alessandra De Palma, Maria Pia Foschini, Tiziana Lazzarotto, Liliana Gabrielli, Pier Luigi Viale, Luciano Attard, Mattia Riefolo, Antonia D'Errico
Summary: Italy was the first European nation to be heavily affected by SARS-CoV-2, with over 33,000 deaths recorded by the end of May 2020. Autopsies on nine patients who died of SARS-CoV-2-associated disease revealed diffuse alveolar damage in lung tissues, with vascular involvement and eosinophilic infiltrate. The presence of SARS-CoV-2 viral RNA in the lung tissues of all nine patients was also confirmed.
JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Chiara Agostinis, Miriam Toffoli, Mariagiulia Spazzapan, Andrea Balduit, Gabriella Zito, Alessandro Mangogna, Luisa Zupin, Tiziana Salviato, Serena Maiocchi, Federico Romano, Sergio Crovella, Francesco Fontana, Luca Braga, Marco Confalonieri, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Summary: This study evaluated the impact of SARS-CoV-2 on pregnant women, identifying important information related to placental cell receptors and susceptibility to infection, as well as highlighting the detrimental effects of Spike protein on pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giulia Pozzi, Elena Masselli, Giuliana Gobbi, Prisco Mirandola, Luis Taborda-Barata, Luca Ampollini, Paolo Carbognani, Cristina Micheloni, Francesco Corazza, Daniela Galli, Cecilia Carubbi, Marco Vitale
Summary: The COVID-19 pandemic has affected nearly 190 million people worldwide with over 4 million confirmed deaths. Finding protective and therapeutic strategies is urgent, and H2S may help reduce the potential for SARS-CoV-2 to enter respiratory epithelial cells.
Review
Virology
Efstathios S. Giotis, Emine Cil, Greg N. Brooke
Summary: COVID-19 has caused over 6.5 million deaths worldwide. The emergence of SARS-CoV-2 variants with increased transmissibility and/or virulence, as well as immune and vaccine escape capabilities, highlights the urgent need for effective antiviral treatments. Men are more susceptible to the virus and have higher rates of severe disease, hospitalization, and mortality, which is associated with sex steroid hormones, particularly androgens. Modulating androgen signaling may be a promising strategy to prevent viral infection and antiandrogens could be used early in COVID-19 to mitigate the disease.
Article
Cell Biology
Rajasekaran Mahalingam, Prakash Dharmalingam, Abirami Santhanam, Sivareddy Kotla, Gangarao Davuluri, Harry Karmouty-Quintana, Guha Ashrith, Rajarajan A. Thandavarayan
Summary: This study analyzed the expression of SARS-CoV-2 virus in human organoid cells using single-cell RNA sequencing data, finding abundant expression of ACE2 and TMPRSS2 in most organoids. It was discovered that low-density lipoprotein receptor expression is enriched in intestinal, lung, and retinal organoid cells. The study demonstrates that organoids can serve as an experimental platform for investigating the disease mechanism of this novel virus and for drug development.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Drucilla J. Roberts, Lisa M. Bebell, Andrea G. Edlow
Summary: The study demonstrates that ACE2 and TMPRSS2 have specific localization and expression patterns in the placenta during late gestation. Early gestation pregnancies may be more vulnerable to infection compared to later gestation pregnancies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Chen Huang, Yu Jiang, Jie Yan
Summary: This study identified that some animals lack key receptors for binding to SARS-CoV-2, potentially reducing their susceptibility to the virus. Additionally, it was found that Ace2 in animals may have lower affinity for SARS-CoV-2 binding compared to human ACE2. The research sheds light on the human-to-animal transmission of SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Te-Kai Sun, Wen-Chin Huang, Yu-Wen Sun, Jeng-Shyan Deng, Liang-Hsuan Chien, Ya-Ni Chou, Wen-Ping Jiang, Jaung-Geng Lin, Guan-Jhong Huang
Summary: The outbreak of COVID-19 caused by SARS-CoV-2 has had a significant global impact, and there are still uncertainties regarding the virus's impact on human health. However, research has found that Schizophyllum commune can reduce the expression of both ACE2 and TMPRSS2 proteins, potentially inhibiting SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Judith Grau-Exposito, David Perea, Marina Suppi, Nuria Massana, Ander Vergara, Maria Jose Soler, Benjamin Trinite, Julia Blanco, Javier Garcia-Perez, Jose Alcami, Anna Serrano-Mollar, Joel Rosado, Vicenc Falco, Meritxell Genesca, Maria J. Buzon
Summary: We developed a rapid platform for studying SARS-CoV-2 by using primary human lung tissue cells directly, which can identify viral targets, express viral entry factors, and screen viral entry inhibitors and anti-inflammatory compounds. The method preserves main immune and structural cell populations, including the most susceptible cell targets for SARS-CoV-2, and maintains the expression of proteins involved in viral infection. Additionally, the method allows for highly reproducible antiviral testing and provides the identification of new compounds missed by conventional systems like VeroE6.
Article
Environmental Sciences
Manon Watzky, Maud de Dieuleveult, Anne Letessier, Claude Saint-Ruf, Benoit Miotto
Summary: This study identified more than 50 chemicals that may regulate key genes involved in cellular entry of the novel coronavirus SARS-CoV-2. The findings suggest that environmental exposures could influence the expression of these genes, potentially impacting our understanding of COVID-19 disease.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biology
Samy Gauthier, Alexy Tran-Dinh, Ian Morilla
Summary: Efforts to understand COVID-19's molecular mechanisms have identified ACE2 as the main receptor for SARS-CoV-2 spike protein. However, the role of other proteins remains unclear. To address this, we modeled the plasma proteome of 384 COVID-19 patients, accurately assessing illness severity and constructing a dynamic model to learn molecular interactions and identify potential treatments.
LIFE SCIENCE ALLIANCE
(2023)
Article
Cell Biology
Thankamani Karthika, Jeswin Joseph, V. R. Akshay Das, Niranjana Nair, Packirisamy Charulekha, Melvin Daniel Roji, V. Stalin Raj
Summary: The cytoplasmic tail of ACE2 is not essential for the entry of SARS-CoV-1 and -2, suggesting that their entry may be mediated via known or unknown host factors. Inhibition of pseudotyped SARS-CoVs entry into cells was observed when treated with a dynamin inhibitor and an endosomal acidification inhibitor. Antibodies against SARS-CoV and soluble ACE2 were unable to enter cells expressing wtACE2 and increment cytACE2.
Review
Cell Biology
Ioannis P. Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E. Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N. Pavlakis, Meletios A. Dimopoulos
Summary: The article discusses the two-phase nature of COVID-19, highlighting the characteristics of increased virus transmission and uncontrolled inflammatory immune responses which can lead to severe complications. The focus is on approaches to suppress viral infection rates, activate adaptive immune responses, and mitigate tissue damage and cytokine storms associated with COVID-19.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yuanyuan Qiao, Xiao-Ming Wang, Rahul Mannan, Sethuramasundaram Pitchiaya, Yuping Zhang, Jesse W. Wotring, Lanbo Xiao, Dan R. Robinson, Yi-Mi Wu, Jean Ching-Yi Tien, Xuhong Cao, Stephanie A. Simko, Ingrid J. Apel, Pushpinder Bawa, Steven Kregel, Sathiya P. Narayanan, Gregory Raskind, Stephanie J. Ellison, Abhijit Parolia, Sylvia Zelenka-Wang, Lisa McMurry, Fengyun Su, Rui Wang, Yunhui Cheng, Andrew D. Delekta, Zejie Mei, Carla D. Pretto, Shaomeng Wang, Rohit Mehra, Jonathan Z. Sexton, Arul M. Chinnaiyan
Summary: Research has shown that androgens regulate the expression of ACE2, TMPRSS2, and AR in lung epithelial cells, affecting the risk of COVID-19 infection in males over 70 years old. The use of AR or BET antagonists can inhibit SARS-CoV-2 infection, providing support for further investigation into transcriptional inhibition for the treatment or prevention of COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
D. Garcia-Azorina, J. Abelaira-Freirec, E. Rodriguez-Adradad, N. Gonzalez-Garcia, A. L. Guerreroa, J. Porta-Etessame, F. J. Martin-Sanchezc
Summary: A study found that more than 85% of patients were under-triaged in the emergency department due to headache, resulting in a failure to detect potential emergencies in a timely manner. Negligence in rapid assessment led to serious misdiagnosis and treatment. Therefore, there is a need to improve the diagnostic and treatment capabilities of physicians for patients with headaches.
Article
Ophthalmology
Julio Gonzalez-Martin-Moro, Jesus Porta Etessam, Belen Pilo de la Fuente, Irene Fuentes Vega, Ines Contreras
Summary: Optical coherence tomography angiography (OCTA) can be used to observe retinal vascular changes during migraine attacks. This case report demonstrates an extensive area of hypoperfusion in the macular region of the right eye using OCTA in a migraine patient. The involvement of only one eye supports the theory of selective retinal ganglion cell layer spreading depression.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
F. Ly-Yang, V. Gomez-Calleja, P. Perez-Garcia, N. Gonzalez-Gomez, J. Porta-Etessam, E. Santos-Bueso
Summary: This article presents 30 clinical cases of photophobia and reviews the literature in order to establish diagnostic criteria for this condition. The results suggest that the underlying causes of photophobia may involve the intrinsically photosensitive retinal ganglion cells as well as neurochemical factors like calcitonin-related peptide and the pituitary activating peptide cyclase. The treatment for photophobia could potentially involve the use of monoclonal antibodies targeting calcitonin-related peptide and/or pituitary activating peptide cyclase.
Article
Clinical Neurology
Maria Diez-Cirarda, Miguel Yus, Natividad Gomez-Ruiz, Carmen Polidura, Lidia Gil-Martinez, Cristina Delgado-Alonso, Manuela Jorquera, Ulises Gomez-Pinedo, Jorge Matias-Guiu, Juan Arrazola, Jordi A. Matias-Guiu
Summary: Diez-Cirarda et al. report persistent structural and functional brain alterations 11 months after acute SARS-CoV-2 infection, which are associated with cognitive dysfunction and contribute to a better understanding of the pathophysiology of the post-COVID syndrome.
Letter
Biochemistry & Molecular Biology
Maria Diez-Cirarda, Miguel Yus, Jorge Matias-Guiu, Jordi A. Matias-Guiu
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Hernan Mejia-Renteria, Alejandro Travieso, Jordi A. Matias-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernandez, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gomez-Garre, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-Garcia, Jorge Matias-Guiu, Javier Escaned
Summary: This study reveals the correlation between coronary microcirculatory dysfunction in patients with coronary artery disease (CAD) and cerebral small vessel disease (CSVD), as well as cognitive impairment.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Clinical Neurology
Jordi A. Matias-Guiu, Alfonso Delgado-Alvarez
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychiatry
Jordi A. Matias-Guiu, Elena Herrera, Maria Gonzalez-Nosti, Kamini Krishnan, Cristina Delgado-Alonso, Maria Diez-Cirarda, Miguel Yus, Alvaro Martinez-Petit, Josue Pagan, Jorge Matias-Guiu, Jose Luis Ayala, Robyn Busch, Bruce P. Hermann
Summary: The objective of this study was to develop objective criteria for cognitive dysfunction associated with the post-COVID syndrome. Four hundred and four patients with post-COVID syndrome were evaluated using comprehensive neuropsychological batteries. The developed criteria classified 41.2% and 17.3% of the sample as having at least one impaired cognitive domain using-1 and-1.5 standard deviations as cutoff points. Cognitive impairment was associated with younger age and lower education levels, but not hospitalization.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Geriatrics & Gerontology
Yuzhen Xu, Ulises Gomez-Pinedo, Jun Liu, Daojun Hong, Jun Xu
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Denise Ojeda-Hernandez, Sarah de la Fuente-Martin, Ola Mohamed-Fathy Kamal, Maria Soledad Benito-Martin, Belen Selma-Calvo, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The implantation of oligodendrocyte precursor cells is a potential therapeutic strategy for remyelination. However, it is unclear how these cells behave after implantation and if they retain the ability to proliferate and differentiate into myelin-forming oligodendrocytes. This study evaluates the impact of corticosteroids on cell proliferation, differentiation, and survival, finding that corticosteroids reduce these capacities and do not support remyelination.
Article
Clinical Neurology
J. Porta-Etessam, S. Santos-Lasaosa, J. Rodriguez-Vico, M. Nunez, A. Ciudad, S. Diaz-Cerezo, M. Comellas, F. J. Perez-Sadaba, L. Lizan, A. L. Guerrero-Peral
Summary: Shared decision-making (SDM) training for neurologists in migraine care does not significantly impact patients’ decisional conflict and patient-physician relationship. However, physicians reported greater satisfaction and confidence in communicating with patients after the training.
NEUROLOGY AND THERAPY
(2023)
Article
Neurosciences
Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Maria Valles-Salgado, Maria Jose Gil-Moreno, Lucia Fernandez-Romero, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study collected and presented normative data on three neuropsychological instruments developed from a cross-cultural perspective in a majority population sample (Spaniards living in Spain) and a minority population sample (Colombians living in Spain). The study found that these instruments have favorable cross-cultural properties and show similar influences of demographic factors in both populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, General & Internal
Maria Diez-Cirarda, Miguel Yus-Fuertes, Rafael Sanchez-Sanchez, Javier J. Gonzalez-Rosa, Gabriel Gonzalez-Escamilla, Lidia Gil-Martinez, Cristina Delgado-Alonso, Maria Jose Gil-Moreno, Maria Valles-Salgado, Fatima Cano-Cano, Denise Ojeda-Hernandez, Natividad Gomez-Ruiz, Silvia Oliver-Mas, Maria Soledad Benito-Martin, Manuela Jorquera, Sarah de la Fuente, Carmen Polidura, Belen Selma-Calvo, Juan Arrazola, Jorge Matias-Guiu, Ulises Gomez-Pinedo, Jordi A. Matias-Guiu
Summary: Cognitive deficits are a major symptom in both COVID-19 patients and post-COVID syndrome (PCS). The hippocampus, a key region for cognition, shows vulnerability to SARS-CoV-2 infection. In PCS patients, hippocampal grey matter atrophy, altered microstructural integrity, hypoperfusion, and functional connectivity changes are observed. Blood biomarkers, such as GFAP, MOG, CCL11, and NfL, show alterations in PCS and are associated with hippocampal volume changes.
Correction
Ophthalmology
J. Gonzalez-Martin-Moro, J. P. Etessam, B. Pilo-de-la-Fuente
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
