Article
Cell Biology
Xiao Tan, Wen-bin Chen, Dao-jun Lv, Tao-wei Yang, Kai-hui Wu, Li-bin Zou, Junqi Luo, Xu-min Zhou, Guo-chang Liu, Fang-peng Shu, Xiang-ming Mao
Summary: The interaction between LncRNA and RNA-binding protein (RBPs) is crucial in regulating tumor progression. SNHG1, a newly discovered lncRNA, competitively interacts with hnRNPL to inhibit E-cadherin translation, ultimately promoting metastasis in prostate cancer (PCa).
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ping-Ping Chen, Zhen-Sheng Zhang, Jin-Cai Wu, Jin-Fang Zheng, Fan Lin
Summary: In this study, it was found that in HCC, SNHG12 promotes EMT by targeting and inhibiting miR-516a-5p, thus upregulating HEG1 expression. Silencing SNHG12 can inhibit proliferation, migration, invasion, and promote apoptosis of HCC cells, while overexpression of SNHG12 produces opposite effects.
CELLULAR SIGNALLING
(2021)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Editorial Material
Oncology
Barbara Pardini, Mihnea P. Dragomir
Summary: The study by Zagorac et al. unveils a novel molecular mechanism in breast cancer involving SOX2, EZH2, and the long noncoding RNA SCIRT. Upregulation of SCIRT may lead to the dedifferentiation of TICs into a less tumorigenic phenotype and offer new therapeutic opportunities.
Article
Oncology
Wanting Song, Jialin Zhu, Chenyan Li, Shiqiao Peng, Mingjun Sun, Yiling Li, Xuren Sun
Summary: This study constructed a predictive model using epithelial-mesenchymal transition (EMT)-related long noncoding RNA (lncRNA) pairs to predict the survival of gastric cancer (GC) patients. Differentially expressed EMT-related lncRNAs were identified and paired, and a risk model was built using univariate and LASSO Cox regression analyses. The model's predictive ability was validated in a testing set, and its prognostic values were evaluated from various perspectives.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Oncology
Wanting Song, Jialin Zhu, Chenyan Li, Shiqiao Peng, Mingjun Sun, Yiling Li, Xuren Sun
Summary: This study constructed a predictive model based on EMT-related lncRNA pairs to predict the survival of gastric cancer patients. The model utilized transcriptome data and clinical information to identify lncRNA pairs with prognostic values and built a risk model to evaluate their impact on patient prognosis.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biology
Zheng Liu, Jie He, Pingsong Jin, Yuxin Ran, Nanlin Yin, Hongbo Qi
Summary: In this study, the researchers found that the CCL21/CCR7 axis affects trophoblast cell migration and invasion by activating the ERK1/2 signaling pathway, which may play a crucial role in the pathogenesis of preeclampsia (PE).
Article
Medicine, Research & Experimental
Mei-Tsz Su, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai, Pao-Lin Kuo
Summary: Preeclampsia is a severe gestational hypertensive disorder that poses a major threat to maternal and fetal health. Aspirin has been shown to effectively reduce the incidence of premature preeclampsia among high-risk pregnant women, possibly by suppressing miR-200 family-mediated cell functions. This study demonstrates a potential mechanism explaining aspirin's effect on preeclampsia prevention and provides a therapeutic target for disease intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Laura Amicone, Alessandra Marchetti, Carla Cicchini
Summary: Epithelial-to-mesenchymal transition (EMT) is a cell differentiation process that gives epithelial cells the ability to move and invade, and its abnormal reactivation in cancer cells is crucial for metastasis. EMT is a dynamic program with various states, and the inverse transition, mesenchymal-to-epithelial transition (MET), is important for colonization of distant sites. Long non-coding RNAs (lncRNAs), specifically HOTAIR, play a critical role in regulating epithelial cell plasticity and EMT in tumors. This review focuses on the molecular mechanisms of HOTAIR expression and its functions in gene regulation and protein activities, as well as the challenges of targeting HOTAIR for therapeutic approaches against EMT.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Developmental Biology
Jaganmoy Choudhury, Deepak Pandey, Pradeep Kumar Chaturvedi, Surabhi Gupta
Summary: This review summarizes the recent research on the epigenetic regulation of epithelial-mesenchymal transition (EMT) occurring in trophoblast cells during placental development. The functional significance of DNA and histone modifications, as well as non-coding RNAs, in transcription regulation and gene expression control, is discussed in relation to trophoblast biology.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Weidun Xie, Xingjian Chen, Zetian Zheng, Fuzhou Wang, Xiaowei Zhu, Qiuzhen Lin, Yanni Sun, Ka-Chun Wong
Summary: This study presents a method called lncRNA-Top to predict lncRNA-gene regulation relationships and constructs controlled deep-learning models. Through case studies, it is found that the predictions are accurate, and additional software is provided for target candidate annotation.
Article
Multidisciplinary Sciences
Zhenchi Li, Jie Zhao, Xing Huang, Jiangping Wang
Summary: Bladder cancer (BC) is an important malignant tumor type, and the role of N7-methyguanosine (m7G)-related lncRNAs in BC remains unclear. In this study, a prognostic model was developed using m7G-related lncRNAs to evaluate BC prognosis and tumor immunity. Patients were classified into high-risk and low-risk groups based on a signature constructed using multivariate Cox and LASSO regression analysis. The signature showed good prognostic value and was associated with tumor immunity. This study highlights the relevance of m7G-related lncRNAs to BC and suggests that the risk signature could serve as a novel prognostic marker for BC patients.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Zhenzhen Wang, Xianghong Cheng, Haiying Wu
Summary: Studies have shown that lncRNA DANCR is down-regulated in placental tissues of patients with preeclampsia, and manipulating its expression can significantly alter trophoblast cell functions. Furthermore, the interaction between lncRNA DANCR and miR-214-5p was confirmed, along with the activation of the PI3K/AKT signaling pathway to promote cell migration and invasion. This suggests a potential new target for therapy in preeclampsia.
Article
Oncology
Zhenqiang Sun, Qin Dang, Zaoqu Liu, Bo Shao, Chen Chen, Yuying Guo, Zhuang Chen, Quanbo Zhou, Shengyun Hu, Jinbo Liu, Weitang Yuan
Summary: The study revealed that LINC01272 is highly expressed in CRC and is associated with poor prognosis, promoting cancer cell invasion and metastasis by regulating miR-876/ITGB2. This suggests that LINC01272 could be a potential therapeutic target for CRC patients in the future.