Article
Immunology
Chaoyue Zheng, Zhen Lu, Haisi Wu, Lulu Cui, Jiacheng Bi, Xiaochun Wan
Summary: The study found that exogenous oxidative stress can inhibit IL-33-induced ILC2 response and airway inflammation, reducing the increase of ILC2 population and recruitment of eosinophils.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Allergy
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang
Summary: The study discovered that by inhibiting thrombin, the maturation of IL-33 can be regulated, thus impacting ILC2s cells and treating lung inflammation.
Article
Immunology
Xi Jing, Anna A. Korchagina, Sergey A. Shein, Wayne T. Muraoka, Ekaterina Koroleva, Alexei V. Tumanov
Summary: IL-23 contributes to intestinal inflammation in C. jejuni infected mice by promoting IL-17 and IFN gamma production by innate lymphoid cells. Reduced levels of pro-inflammatory cytokines and immune cell accumulation in the colon were observed in IL-23(-/-) mice, independent from bacterial clearance. Flow cytometry analysis revealed a decrease in IL-17 and IFN gamma production by group 1 and 3 innate lymphoid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Lu Wang, Yan Luo, Liping Luo, Dandan Wu, Xiaofeng Ding, Handong Zheng, Haisha Wu, Bilian Liu, Xin Yang, Floyd Silva, Chunqing Wang, Xing Zhang, Xianyun Zheng, Jindong Chen, Jonathan Brigman, Michael Mandell, Zhiguang Zhou, Feng Liu, Xuexian O. Yang, Meilian Liu
Summary: The study demonstrates that AMPK phosphorylation via TAK1 is the activation mechanism of ILC2 in adipose tissue, and adiponectin negatively regulates the function of ILC2 through AMPK-mediated inhibition of IL-33 signaling, thereby suppressing thermogenesis. Adiponectin deficiency increases the proportion and activation of ILC2, leading to upregulation of thermogenic gene expression in adipose tissue.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Allergy
Jacqueline-Yvonne Cephus, Vivek D. Gandhi, Ruchi Shah, Jordan Brooke Davis, Hubaida Fuseini, Jeffrey A. Yung, Jian Zhang, Hirohito Kita, Vasiliy V. Polosukhin, Weisong Zhou, Dawn C. Newcomb
Summary: In this study, estrogen receptor-alpha signaling was found to increase IL-33 release and ILC2-mediated airway inflammation. Esr1-deficient mice showed significantly reduced IL-5, IL-13 production, BAL eosinophils, and IL-33 release, while PPT and 17β-estradiol increased IL-33 gene expression and release.
Article
Immunology
Sharon Van Nevel, Judith van Ovost, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, Olga Krysko
Summary: This study investigates the role of neutrophils in allergic airway inflammation in BALB/c and C57BL/6 mice exposed to Alternaria alternata. The findings demonstrate that BALB/c mice show a neutrophilic response to Alt extract, while C57BL/6 mice exhibit eosinophilic infiltration as the main response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fan Deng, Jing-Juan Hu, Xiao Yang, Qi-Shun Sun, Ze-Bin Lin, Bing-Cheng Zhao, Zhi-Wen Yao, Si-Dan Luo, Ze-Ling Chen, Ying Liu, Zheng-Zheng Yan, Cai Li, Wei-Feng Liu, Ke-Xuan Liu
Summary: The study demonstrates that pravastatin can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s, revealing a novel mechanism and therapeutic strategy for intestinal I/R injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mourad Azzout, Celine Dietrich, Francois Machavoine, Pauline Gastineau, Alix Bottier, Guillaume Lezmi, Maria Leite-de-Moraes
Summary: IL-33 combined with IL-12 can directly target MAIT cells to induce their activation and cytokine production. This novel mechanism of IL-33 activation provides insight into the mode of action by which human MAIT cells can promote inflammatory responses in a TCR-independent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Yuka Hosotani, Koubun Yasuda, Makoto Nagai, Kiyofumi Yamanishi, Nobuo Kanazawa, Fumi Gomi, Yasutomo Imai
Summary: ILC2 cells play a crucial role in IL-33-induced keratoconjunctivitis. Through single-cell RNA sequencing analysis, it was found that ILC2 cells infiltrated the conjunctival epithelium and subepithelial tissue. Moreover, the use of tacrolimus in treatment can inhibit cytokine production from ILC2 cells and alleviate IL-33-induced keratoconjunctivitis.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Jessica E. Miller, Harshavardhan Lingegowda, Lindsey K. Symons, Olga Bougie, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: The study found that IL-33 contributes to the expansion of ILC2s in both humans and murine models, regulating the microenvironment of endometriosis lesions, and driving severe endometriosis symptoms such as inflammation, lesion proliferation, and fibrosis. IL-33 neutralization shows promise as a potential novel therapeutic avenue for treating the debilitating symptoms of endometriosis.
Article
Surgery
Yizhan Guo, Zhongcheng Mei, Dongge Li, Anirban Banerjee, May A. Khalil, Allen Burke, Jon Ritter, Christine Lau, Daniel Kreisel, Andrew E. Gelman, Elizabeth Jacobsen, Irina G. Luzina, Sergei P. Atamas, Alexander Sasha Krupnick
Summary: Pathways regulating lung alloimmune responses differ from other organs and are poorly understood. Using a mouse lung transplant model, we found that immunosuppression increases eosinophil infiltration into the allograft in an IL-5-dependent manner. Ischemia reperfusion injury upregulates IL-33 expression and promotes IL-5 production by graft-resident ILC2, leading to downregulation of alloimmune responses.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Allergy
Fengfei Sun, Wei Zou, Honglei Shi, Zehu Chen, Donghai Ma, Minmin Lin, Kongqiu Wang, Yiying Huang, Xiaobin Zheng, Cuiyan Tan, Meizhu Chen, Changli Tu, Zhenguo Wang, Jian Wu, Weiming Wu, Jing Liu
Summary: This study found that interleukin-33 (IL-33) can stimulate and activate ILC2 cells in patients with eosinophilic asthma (EA), and the number and activity of these cells are associated with asthma control and eosinophilic airway inflammation. In addition, inhibiting the PI3K/AKT pathway can reduce the production of IL-5 and IL-13 by ILC2 cells. Therefore, using anti-IL-33 antibody may be an effective treatment strategy for EA.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Cell Biology
Hao Li, Xiaoyu Yu, Baojie Shi, Kun Zhang, Liyun Yuan, Xueni Liu, Pusen Wang, Junwei Lv, Guangxun Meng, Qiankun Xuan, Wenjuan Wu, Bin Li, Xiao Peng, Xuebin Qin, Wanqing Liu, Lin Zhong, Zhihai Peng
Summary: The study revealed that genetic predisposition to reduced PANX1 function increases the risk of MRSA infection in liver transplantation patients. Panx1 deficiency results in increased MRSA-induced liver injury and animal death. Decreased PANX1 expression leads to reduced ATP release from hepatocytes and impairs hepatic host innate immune response mediated by IL-33.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Giuseppe Ercolano, Alejandra Gomez-Cadena, Nina Dumauthioz, Giulia Vanoni, Mario Kreutzfeldt, Tania Wyss, Liliane Michalik, Romain Loyon, Angela Ianaro, Ping-Chih Ho, Christophe Borg, Manfred Kopf, Doron Merkler, Philippe Krebs, Pedro Romero, Sara Trabanelli, Camilla Jandus
Summary: The expression of PPARγ in ILC2s sustains type-2 cytokines secretion and supports their pro-tumorigenic role in preclinical cancer models. Pharmacologic inhibition or genetic deletion of PPARγ in ILC2s significantly impair IL-33-induced Type-2 cytokine production and mitochondrial fitness.
NATURE COMMUNICATIONS
(2021)
Article
Allergy
Rinna Tei, Koji Iijima, Koji Matsumoto, Takao Kobayashi, Jyoti Lama, Elizabeth A. Jacobsen, Hirohito Kita
Summary: This study investigates the immunologic mechanisms involved in the regulation of lung innate lymphoid cells (ILC2s) and suggests that interferon-beta (IFN-beta) can inhibit the survival and effector functions of lung ILC2s, providing a potential new strategy for treating diseases associated with ILC2s.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
R. Stokes Peebles
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Allergy
Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Hirohito Kita
Summary: This study investigates the role of the inhibitory receptor programmed cell death protein 1 (PD-1) in allergic immune responses and found that blockade of the PD-1 pathway can protect against allergic immune responses. The direct interaction between Tfh cells and B cells may play a pivotal role in controlling antibody quality and clinical manifestation of allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Allergy
Hirohito Kita
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
Summary: This study developed a mouse model to simulate the effects of early introduction of peanut products on peanut allergies. The results showed that ingestion of a peanut product protected mice from peanut allergy induced by environmental exposure. The CTLA-4 pathway, which regulates Tfh cell responses, played a pivotal role in this protection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Alfred D. Doyle, Mia Y. Masuda, Grace C. Pyon, Huijun Luo, Arina Putikova, William E. LeSuer, Samuel Flashner, Matthew A. Rank, Hiroshi Nakagawa, Hirohito Kita, Benjamin L. Wright
Summary: Exposure to the detergent SDS decreases esophageal barrier integrity, stimulates IL-33 production, and promotes epithelial hyperplasia and tissue eosinophilia. Detergents may be a key environmental trigger in EoE pathogenesis.
Editorial Material
Critical Care Medicine
Burton F. Dickey, Jichao Chen, R. Stokes Peebles
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Immunology
Hirohito Kita
Summary: This passage describes the transfer of IL-33 from the nucleus to the cytoplasm and its extracellular release through gasdermin D pores in airway epithelial cells exposed to allergen proteases.
Editorial Material
Immunology
Ashley Y. Wu, R. Stokes Peebles
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Allergy
Jyoti K. Lama, Hirohito Kita
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Takao Kobayashi, Koji Iijima, Koji Matsumoto, Jyoti K. Lama, Hirohito Kita
Summary: This study investigated the mechanisms behind the persistent type 2 immunity in chronic airway diseases such as asthma. Mouse models were used to show that CD69+ST2+ TH2 memory cells quickly develop in lung tissue after initial allergen exposure and persist for a prolonged period. The ST2/IL-33 pathway may play a role in the development of immune memory in lung to certain allergens.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kunj Patel, R. Stokes Peebles
Summary: Prostacyclin is a metabolic product of the cyclooxygenase pathway with constitutive expression and anti-inflammatory effects. Evidence suggests that it may serve as an additional therapeutic target for treating allergic inflammation and asthma.
Letter
Critical Care Medicine
Allison E. Norlander, Masako Abney, Jacqueline-Yvonne Cephus, Caroline E. Roe, Jonathan M. Irish, Nicholas J. Shelburne, Dawn C. Newcomb, Anna R. Hemnes, R. Stokes Peebles
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Vivek D. Gandhi, Jacqueline-Yvonne Cephus, Allison E. Norlander, Nowrin U. Chowdhury, Jian Zhang, Zachary J. Ceneviva, Elie Tannous, Vasiliy V. Polosukhin, Nathan D. Putz, Nancy Wickersham, Amrit Singh, Lorraine B. Ware, Julie A. Bastarache, Ciara M. Shaver, Hong Wei Chu, R. Stokes Peebles, Dawn C. Newcomb
Summary: Women have a higher prevalence of asthma than men. Androgen receptor signaling has been found to stabilize Treg suppressive function, decrease the number of ST2(+) ex-Tregs and IL-13(+) Th2 cells, and reduce IL-33 production.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Allergy
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
Summary: A mouse model was developed to simulate the LEAP study, showing that ingestion of a peanut product can protect mice from peanut allergy induced by environmental exposure, possibly through the CTLA-4 pathway regulating Tfh cell responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)