T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome

Lamin A/C deficiency in CD4 + T‐cells enhances regulatory T‐cells and prevents inflammatory bowel disease

(2019) Raquel Toribio‐Fernández et al.   JOURNAL OF PATHOLOGY

Cre-loxP Reporter Mouse Reveals Stochastic Activity of the Foxp3 Promoter

(2019) Peter D. Bittner-Eddy et al.   Frontiers in Immunology

Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting

(2019) Chichu Xie et al.   Cells

Ectopic germline recombination activity of the widely used Foxp3‐YFP‐Cre mouse: a case report

(2019) Dan Wu et al.   IMMUNOLOGY

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

(2018) Prashant Rajbhandari et al.   CELL

Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major

(2018) Raquel Toribio-Fernández et al.   Cell Death & Disease

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Characterization of regulatory T cells in obese omental adipose tissue in humans

(2018) Dan Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4 + T Cell Dysfunction

(2017) Jie Wu et al.   IMMUNITY

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity

(2017) Henrike J. Fischer et al.   JOURNAL OF IMMUNOLOGY

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Obesity-Associated Adipose Tissue Inflammation and Transplantation

(2016) D. Wu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis

(2016) Sihua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR inhibitors effects on regulatory T cells and on dendritic cells

(2016) Giovanni Stallone et al.   Journal of Translational Medicine

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

(2015) Dasa Medrikova et al.   PLoS One

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells

(2014) Dean Franckaert et al.   IMMUNOLOGY AND CELL BIOLOGY

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Reduced UCP-1 Content in In Vitro Differentiated Beige/Brite Adipocytes Derived from Preadipocytes of Human Subcutaneous White Adipose Tissues in Obesity

(2014) Andrew L. Carey et al.   PLoS One

Appearance and disappearance of the mRNA signature characteristic of Tregcells in visceral adipose tissue: Age, diet, and PPARγ effects

(2014) Daniela Cipolletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization, Identification, and Excision of Murine Adipose Depots

(2014) Adrien Mann et al.   Jove-Journal of Visualized Experiments

Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration

(2013) Yun-Hee Lee et al.   Cell Metabolism

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Insulin Inhibits IL-10-Mediated Regulatory T Cell Function: Implications for Obesity

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer

(2012) M. Terme et al.   CANCER RESEARCH

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Insulin and its analogues and their affinities for the IGF1 receptor

(2012) Aimee J Varewijck et al.   ENDOCRINE-RELATED CANCER

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling

(2009) Alicia H. Clementi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Foxp3 Processing by Proprotein Convertases and Control of Regulatory T Cell Function

(2008) Edwin F. de Zoeten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY