期刊
JOURNAL OF CONTROLLED RELEASE
卷 324, 期 -, 页码 341-353出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2020.05.016
关键词
Bio-mimetic nanocarrier; Tumor targeting; Drug nanocrystals; Postoperative chemotherapy; Breast cancer
资金
- National Natural Science Foundation of China, China [81903545]
- Fundamental Research Funds for the Central Universities, China [BMU2017YJ001]
- Beijing Natural Science Foundation, China [7204261]
- National Major Science and Technology Projects of China, China [2018ZX09721003]
Chemotherapy post cancer surgery has important clinical significance for reducing the chance of recurrent-metastasis. However, postoperative chemotherapy efficacy is hampered by poor targeting capability and dose-limiting toxicity of chemo-drugs. Herein, we report a bio-mimetic platelet membrane-cloaked paclitaxel nano-crystal system (PPNCs), which consists of spherical paclitaxel nanocrystals (PNCs) as a high-dose drug core, polyethylene glycol-conjugated paclitaxel (PEG-PTX) as an amphiphilic molecule to adjust the surface hydrophilicity of PNCs and the shell of platelet membrane that can target surgical coagulation site. The in vitro characterization of PPNCs exhibited uniform particle size distribution, high drug loading, and good stability, which are crucial for effective drug delivery. At cell levels, PPNCs showed greater cellular uptake and higher cytotoxicity in 4T1 breast cancer cells than bare PNCs. In vivo, the nanoparticles could deliver high-dose chemodrugs and target the coagulation site caused by surgery or vascular disrupting agents, resulting in enhanced antitumor efficacy and reduced systemic toxicities. In general, the PPNCs system can be served as a promising and efficient drug delivery system for postoperative chemotherapy.
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