Article
Oncology
Xuan Zou, Xuan Lin, He Cheng, Yusheng Chen, Ruijie Wang, Mingjian Ma, Yu Liu, Zhengjie Dai, Yesboli Tasiheng, Yu Yan, Qinqin Hou, Fei Ding, Huan Chen, Xianjun Yu, Xu Wang, Chen Liu
Summary: This study systematically revealed the cellular properties and prognostic values of intratumoral TLSs in pancreatic ductal adenocarcinoma (PDAC) and described the potential impact of neoadjuvant treatment (NAT) on TLS development and function.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Byeong Geun Song, Wooil Kwon, Hyemin Kim, Eun Mi Lee, Young Min Han, Hongbeom Kim, Yoonhyeong Byun, Kyung Bun Lee, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Jin-Young Jang, Joo Kyung Park
Summary: CTCs can be reliably identified in early stages of PDACs, with CTC count potentially serving as a prognostic marker for resectable PDAC patients' survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Christine Nitschke, Benedikt Markmann, Marie Tolle, Jolanthe Kropidlowski, Yassine Belloum, Mara R. Goetz, Hartmut Schluter, Marcel Kwiatkowski, Marianne Sinn, Jakob Izbicki, Klaus Pantel, Cenap Gungor, Faik G. Uzunoglu, Harriet Wikman
Summary: This study used a microfluidic-based approach to detect circulating tumor cells (CTCs) in patients with pancreatic ductal adenocarcinoma (PDAC), and assessed the expression of retinoic acid receptor responder 1 (RARRES1) on CTCs for the first time. The results showed that the detection rate of CTCs was higher during follow-up, and high CTC counts during follow-up in resected patients were associated with early tumor relapse. Combining CTC detection and RARRES1 expression could predict a worse prognosis in patients after curative operation during follow-up.
Article
Gastroenterology & Hepatology
Xudong Zhao, Yongsu Ma, Xiu Dong, Zhengkui Zhang, Xiaodong Tian, Xiaohang Zhao, Yinmo Yang
Summary: The study demonstrated the potential clinical value of isolating and characterizing heterogeneous sub-populations of CTCs in PDAC patients. Both EMT-related CTCs and hENT-1 expression in CTCs were identified as potential prognostic biomarkers for recurrence free survival in resected patients receiving adjuvant gemcitabine-based chemotherapy.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Hyemin Kim, Chan Mi Heo, Jinmyeong Oh, Hwe Hoon Chung, Eun Mi Lee, Juhee Park, Se-Hoon Lee, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Yoon-Kyoung Cho, Joo Kyung Park
Summary: This study investigated the feasibility of using CTCs for monitoring disease progression, chemotherapy response, and survival in patients with unresectable PDAC. CTCs were detected in 84.62% of patients at the time of diagnosis, and a decrease in CTCs after chemotherapy was significantly associated with longer survival.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Yujin Pan, Deyu Li, Jiuhui Yang, Ning Wang, Erwei Xiao, Lianyuan Tao, Xiangming Ding, Peichun Sun, Dongxiao Li
Summary: This study demonstrates the preferability of portal venous for CTC testing and the association of high PoV M-CTC count with increased risk of metastasis and shorter survival time in resectable PDAC patients. PoV CTC phenotype detection shows potential as a reliable and accurate tool for identifying high-risk PDAC patients for better management strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christine Nitschke, Benedikt Markmann, Leonie Konczalla, Jolanthe Kropidlowski, Thais Pereira-Veiga, Pasquale Scognamiglio, Martin Schonrock, Marianne Sinn, Marie Tolle, Jakob Izbicki, Klaus Pantel, Faik G. Uzunoglu, Harriet Wikman
Summary: This study found that the detection of CAMLs can provide prognostic information in PDAC patients, particularly when combined with CTCs. This indicates the potential of liquid biopsy marker analyses.
Article
Oncology
Ioana Plesca, Iva Benesova, Carolin Beer, Ulrich Sommer, Luise Mueller, Rebekka Wehner, Max Heiduk, Daniela Aust, Gustavo Baretton, Michael P. Bachmann, Anja Feldmann, Juergen Weitz, Lena Seifert, Adrian M. Seifert, Marc Schmitz
Summary: Tumor-infiltrating dendritic cells (DCs) are associated with survival of pancreatic ductal adenocarcinoma (PDAC) patients. Specifically, a higher frequency of cDC1s infiltration in the whole tumor area and tumor stroma, as well as an increased frequency of cDC2s infiltration in the intraepithelial tumor, is associated with improved survival.
Article
Chemistry, Analytical
Pablo J. Dopico, Minh-Chau N. Le, Benjamin Burgess, Zhijie Yang, Yu Zhao, Youxiang Wang, Thomas J. George, Z. Hugh Fan
Summary: While patients with resectable pancreatic ductal adenocarcinoma (PDAC) show improved survival, their survival remains low due to occult metastatic disease and treatment resistance. This study tracked circulating biomarkers in resectable PDAC patients throughout treatment and found that the majority of these biomarkers were detected after the start of neoadjuvant therapy but before surgery.
Article
Multidisciplinary Sciences
Jie Ju, Leonoor V. Wismans, Dana A. M. Mustafa, Marcel J. T. Reinders, Casper H. J. van Eijck, Andrew P. Stubbs, Yunlei Li
Summary: A novel deep learning model, MODEL-P, has been proposed for identifying PDAC subtypes and predicting prognoses effectively, which can distinguish two PDAC subtypes with distinct survival outcomes and help clinicians better assess risks and benefits in treatment decisions.
Article
Oncology
Frederik J. Hansen, Paul David, Marina Akram, Samuel Knoedler, Anke Mittelstaedt, Susanne Merkel, Malgorzata J. Podolska, Izabela Swierzy, Lotta Rossdeutsch, Bettina Kloesch, Dina Kouhestani, Anna Anthuber, Alan Benard, Maximilian Brunner, Christian Krautz, Robert Gruetzmann, Georg F. Weber
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease associated with elevated levels of circulating monocytes, which are correlated with aggressive tumor growth and decreased survival. Monocytes may serve as a novel prognostic biomarker for PDAC and further research is needed to investigate their potential as therapeutic targets.
Review
Oncology
James T. Topham, Daniel J. Renouf, David F. Schaeffer
Summary: Over the past decade, research on pancreatic ductal adenocarcinoma (PDAC) has revealed a diverse somatic mutation landscape and the development of targeted therapies. However, the direct translation of genomics research into clinical care remains a critical need, hindered by the expensive and time-consuming technologies used to identify actionable mutations. Liquid biopsy tumor profiling using ctDNA offers a solution by overcoming these challenges and providing faster results. This review highlights the advances, limitations, and opportunities of ctDNA sequencing technology in PDAC and its potential to transform clinical decision-making.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Review
Oncology
Ashleigh R. Poh, Matthias Ernst
Summary: Macrophages play a crucial role in the pancreatic tumor microenvironment and are associated with poor patient survival. Pre-clinical studies have shown the diverse contributions of macrophages in PDAC development, however, the effectiveness of macrophage-targeting therapies in clinical trials is inconsistent.
Article
Oncology
Chengsi Wu, Yizhen Liu, Dianhui Wei, Li Tao, Lili Yuan, Tiantian Jing, Boshi Wang
Summary: This study used single-cell data and WGCNA to investigate the interaction between pancreatic cancer cells and the tumor microenvironment (TME). Prognosis prediction models were constructed and the role of the ITGA2 gene in pancreatic cancer malignancy was identified. Inhibition of ITGA2 attenuated tumor development and improved pancreatic lesions. These findings provide novel insights into PDAC therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hyeong Seok Kim, Wookyeong Song, Wonho Choo, Sungyoung Lee, Youngmin Han, Claudio Bassi, Roberto Salvia, Giovanni Marchegiani, Christopher L. Wolfgang, Jin He, Alex B. Blair, Michael D. Kluger, Gloria H. Su, Song Cheol Kim, Ki-Byung Song, Masakazu Yamamoto, Takashi Hatori, Ching-Yao Yang, Hiroki Yamaue, Seiko Hirono, Sohei Satoi, Tsutomu Fujii, Satoshi Hirano, Wenhui Lou, Yasushi Hashimoto, Yasuhiro Shimizu, Marco Del Chiaro, Roberto Valente, Matthias Lohr, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo, Fuyuhiko Motoi, Ippei Matsumoto, Woo Jung Lee, Chang Moo Kang, Yi-Ming Shyr, Shin-E Wang, Ho-Seong Han, Yoo-Seok Yoon, Marc G. Besselink, Nadine C. M. van Huijgevoort, Masayuki Sho, Hiroaki Nagano, Sang Geol Kim, Goro Honda, Yinmo Yang, Hee Chul Yu, Jae Do Yang, Jun Chul Chung, Yuichi Nagakawa, Hyung Il Seo, Seungyeoun Lee, Hongbeom Kim, Wooil Kwon, Taesung Park, Jin-Young Jang
Summary: A novel nomogram based on radiologic findings of intraductal papillary mucinous neoplasms (IPMN) was developed and compared with existing American and Korean/Japanese nomograms. The results showed that this nomogram performed better than the American nomogram and was comparable to the Korean/Japanese nomogram. This nomogram would be clinically helpful in situations where tumor markers are not available.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Ophthalmology
Susan P. Mollan, Dun Jack Fu, Ching-Yi Chuo, Jacqueline G. Gannon, Wen Hwa Lee, J. Jill Hopkins, Cian Hughes, Alastair K. Denniston, Pearse A. Keane, Ronald Cantrell
Summary: By combining data from a national digital health data repository with historical clinical trial data, we demonstrate an enhanced predictive modeling in nAMD. The detrimental effects of prolonged treatment delay should motivate healthcare providers to support nAMD patients in accessing care in safe environments.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Krishna M. Gokhale, Nicola J. Adderley, Anuradhaa Subramanian, Wen Hwa Lee, Diana Han, Jesse Coker, Tasanee Braithwaite, Alastair K. Denniston, Pearse A. Keane, Krishnarajah Nirantharakumar
Summary: This study aimed to explore the relationship between metformin use and the development of AMD in patients with type 2 diabetes in the UK. The results showed that there was no association between the use of metformin and the risk of developing AMD, regardless of whether other antidiabetic medications were also used.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hebin Wang, Ding Ding, Tingting Qin, Hang Zhang, Jun Liu, Junfang Zhao, Chien-Hui Wu, Ammar Javed, Christopher Wolfgang, Shiwei Guo, Qingmin Chen, Weihong Zhao, Wei Shi, Feng Zhu, Xingjun Guo, Xu Li, Feng Peng, Ruizhi He, Simiao Xu, Jikuan Jin, Yi Wu, Abula Nuer, Barish Edil, Yu-Wen Tien, Gang Jin, Lei Zheng, Jin He, Jianhua Liu, Yahui Liu, Min Wang, Renyi Qin
Summary: In this study, we validated the value of AJCC 8 and other coexisting staging systems for well differentiated pNETs. The results showed that AJCC 8 had a more reasonable proportional distribution and the risk of death was better correlated with disease stage.
Article
Oncology
Yi-Lun Chen, Chiao-Ling Tsai, Jason Chia-Hsien Cheng, Chun-Wei Wang, Shih-Hung Yang, Yu-Wen Tien, Sung-Hsin Kuo
Summary: This study investigated potential factors and clinical outcomes in patients with locally advanced pancreatic cancer who received definitive radiotherapy. The results indicate that pre-RT NLR and post-RT monitoring of CA19-9 and tumor size reduction can help predict patient prognosis. The incorporation of systemic treatments during and after radiotherapy may improve outcomes for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yi-Ing Chen, Chin-Chun Chang, Min-Fen Hsu, Yung-Ming Jeng, Yu-Wen Tien, Ming-Chu Chang, Yu-Ting Chang, Chun-Mei Hu, Wen-Hwa Lee
Summary: The direct interaction between tumor cells and bound fibroblasts in pancreatic ductal adenocarcinoma (PDAC) can influence tumor cell behavior. By investigating the interaction between pancreatic cancer cells and fibroblasts, this study reveals that homophilic ATP1A1 binding induces fibroblasts to secrete activin A, promoting epithelial-mesenchymal transition of tumor cells and activation of myofibroblasts.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Chien-Hui Chan, Li-Wen Chiou, Tsai-Yu Lee, Yun-Ru Liu, Tsung-Han Hsieh, Ching-Yao Yang, Yung-Ming Jeng
Summary: The activation of PAK through cell-matrix interaction mediates resistance to sotorasib through the activation of MAPK and PI3K pathways.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Che-Ming Chiang, Yung-Ming Jeng, Ming-Chih Ho, Ming-Wei Lai, Huei-Ying Li, Pei-Lung Chen, Ni-Chung Lee, Jia-Feng Wu, Yu-Chun Chiu, Bang-Yu Liou, Yen-Hsuan Ni, Hong-Yuan Hsu, Mei-Hwei Chang, Huey-Ling Chen
Summary: This study investigated the clinical and genetic features of patients with Alagille syndrome (ALGS) and compared their liver pathology at liver transplantation (LT) with patients with biliary atresia (BA). The results showed that one-third of ALGS patients had a favorable course and lesser extent of liver cirrhosis compared to BA patients at the time of LT.
Letter
Gastroenterology & Hepatology
Chien-Hui Wu, Kao-Lang Liu, Po-Chin Liang, Tzu-Pin Lu, Ting-Chun Kuo, Yu-Wen Tien
Article
Oncology
Jin-Ming Wu, Young-Jen Lin, Chien-Hui Wu, Ting-Chun Kuo, Yu-Wen Tien
Summary: This study compared the effectiveness of two methods for preventing and treating postoperative pancreatic fistulas (POPFs) after pancreaticoduodenectomy (PD). It found that the modified non-duct-to-mucosa pancreaticojejunostomy (TPJ) was associated with a lower incidence of bile leakage, postpancreatectomy hemorrhage (PPH), and intra-abdominal abscess (IAA) compared to the conventional method (CPJ).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ting -Fang Che, Chao-Hua Chiu, Yu-Chung Wu, Jia-Yang Chen, Teh-Ying Chou, Yi-Chun Cheng, Chi-Lu Chiang, Chien-Sheng Huang, I-Shuan Tuang, Yang-Hui Ho, Jian-Hua Hong, Yen-Jang Huang, Hsiang-Ling Ho, Ying-Chih Chang
Summary: We evaluated the clinical significance of circulating tumor cells (CTCs) in lung adenocarcinoma (LUAD) by combining efficient CTC isolation and in-vitro cultivation. The cultured CTC count and proliferative ability were highly associated with cancer prognosis, indicating their potential as prognostic biomarkers in LUAD patients.
Article
Oncology
Yu-Ting Chang, Hsuan-Yu Peng, Chun-Mei Hu, Sui-Chih Tien, Yi-Ing Chen, Yung-Ming Jeng, Ming-Chu Chang
Summary: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between cancer cells and fibroblasts, are also critical for cancer progression and metastasis. In this study, we found that ezrin (EZR) in PDAC cell-derived sEVs can activate fibroblasts and promote PDAC cell proliferation, invasion, and liver metastasis through the STAT3 and YAP-1 signaling pathways.
MOLECULAR ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Fu-Ting Hsiao, Hung-Jen Chien, Ya-Hsien Chou, Shih-Jung Peng, Mei-Hsin Chung, Tzu-Hui Huang, Li-Wen Lo, Chia-Ning Shen, Hsiu-Pi Chang, Chih-Yuan Lee, Chien-Chia Chen, Yung-Ming Jeng, Yu-Wen Tien, Shiue-Cheng Tang
Summary: Embedding mouse and human tissues with a solid high-refractive-index acrylamide-based copolymer allows for clear imaging and preservation of tissue optical and fluorescent features.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Po-Ying Yeh, Jia-Yang Chen, Mo-Yuan Shen, Ting-Fang Che, Syer Choon Lim, Jocelyn Wang, Wen-Sy Tsai, Curtis W. Frank, Chun-Jen Huang, Ying-Chih Chang
Summary: Due to the scarcity, vulnerability, and heterogeneity of circulating tumor cells (CTCs), the existing CTC isolation system based on immunoaffinity interaction lacks consistent efficiency. The newly developed LIPO-SLB platform, incorporating a chaotic-mixing microfluidic system and antibody-conjugated liposome-tethered-supported lipid bilayer, offers high CTC capture efficiency, viability, and selectivity. The platform has been successfully validated using different cancer cell lines and clinical samples, demonstrating its enormous potential for prognostic and predictive purposes in precision medicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Oncology
Po-Han Lin, Yun-Wen Tien, Wen-Fang Cheng, Ying-Cheng Chiang, Chien-Huei Wu, Karen Yang, Chiun-Sheng Huang
Summary: Genetic high-risk assessment combines hereditary breast, ovarian, and pancreatic cancer into one syndrome, but there is a lack of data for comparing the germline mutational spectrum of the cancer predisposing genes between these three cancers. In this study, patients who met the criteria of hereditary breast, ovarian, and pancreatic cancer were enrolled and received multi-gene sequencing. The results showed that the mutation spectrum varies across the three cancer types and family histories, providing guidance for physicians, counselors, and counselees.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
