γ9δ2T cell diversity and the receptor interface with tumor cells

TEG011 persistence averts extramedullary tumor growth without exerting off‐target toxicity against healthy tissues in a humanized HLA‐A*24:02 transgenic mice

(2020) Inez Johanna et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivity

(2020) Anke Janssen et al.   Cancer Immunology Research

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

Evaluating in vivo efficacy – toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells

(2019) Inez Johanna et al.   Journal for ImmunoTherapy of Cancer

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

(2019) Anna M. Paczulla et al.   NATURE

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

(2019) Zsolt Sebestyen et al.   NATURE REVIEWS DRUG DISCOVERY

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

(2019) Trudy Straetemans et al.   MOLECULAR THERAPY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrophilin3A proteins and Vγ9Vδ2 T cell activation

(2018) Siyi Gu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

(2018) Trudy Straetemans et al.   Frontiers in Immunology

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

(2018) Martine J. Kallemeijn et al.   Frontiers in Immunology

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

(2018) Maaike V. J. Braham et al.   OncoImmunology

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

Nature Biotechnology's academic spinouts of 2016

(2017) Aaron Bouchie et al.   NATURE BIOTECHNOLOGY

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment

(2016) Jia Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Heterogeneous yet stable Vδ2(+)T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals

(2016) Paul L. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

(2016) Zsolt Sebestyen et al.   Cell Reports

Untouched GMP-Ready Purified Engineered Immune Cells to Treat Cancer

(2015) T. Straetemans et al.   CLINICAL CANCER RESEARCH

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

(2015) Christopher C. Valley et al.   MOLECULAR BIOLOGY OF THE CELL

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells

(2015)   Oncotarget

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Definition of APC Presentation of Phosphoantigen (E)-4-Hydroxy-3-methyl-but-2-enyl Pyrophosphate to V 2V 2 TCR

(2014) H. Wei et al.   JOURNAL OF IMMUNOLOGY

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity

(2014) Wouter Scheper et al.   Frontiers in Immunology

Clinical Applications of Gamma Delta T Cells with Multivalent Immunity

(2014) Drew C. Deniger et al.   Frontiers in Immunology

Hunting for clinical translation with innate-like immune cells and their receptors

(2013) W Scheper et al.   LEUKEMIA

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

MiTCR: software for T-cell receptor sequencing data analysis

(2013) Dmitriy A Bolotin et al.   NATURE METHODS

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional γδ T cells and their receptors for targeted anticancer immunotherapy

(2013) Wouter Scheper et al.   OncoImmunology

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies

(2012) Aparna Palakodeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redirecting   T cells against cancer cells by transfer of a broadly tumor-reactive   T-cell receptor

(2011) V. Marcu-Malina et al.   BLOOD

Searching for “signal 2”: costimulation requirements of γδ T cells

(2011) Julie C. Ribot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

T-cell synapse formation depends on antigen recognition but not CD3 interaction: Studies with TCR:ζ, a candidate transgene for TCR gene therapy

(2011) János Roszik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Direct stochastic optical reconstruction microscopy with standard fluorescent probes

(2011) Sebastian van de Linde et al.   Nature Protocols

Simultaneous multiple-emitter fitting for single molecule super-resolution imaging

(2011) Fang Huang et al.   Biomedical Optics Express

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Fast, single-molecule localization that achieves theoretically minimum uncertainty

(2010) Carlas S Smith et al.   NATURE METHODS

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

(2009) Rebekah R. Bartelt et al.   PLoS One