Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

(2019) Lauren M. Hablitz et al.   Science Advances

PDGF-B Is Required for Development of the Glymphatic System

(2019) Anne Sofie Munk et al.   Cell Reports

Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels

(2019) Qiaoli Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Voluntary running enhances glymphatic influx in awake behaving, young mice

(2018) Stephanie von Holstein-Rathlou et al.   NEUROSCIENCE LETTERS

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow

(2017) Tsutomu Nakada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

Impairment of the glymphatic system after diabetes

(2016) Quan Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glymphatic clearance controls state-dependent changes in brain lactate concentration

(2016) Iben Lundgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

(2016) Chenchen Pan et al.   NATURE METHODS

Changes in the composition of brain interstitial ions control the sleep-wake cycle

(2016) Fengfei Ding et al.   SCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

(2015) Sebastian Palmqvist et al.   NEUROLOGY

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)

(2012) Ali Ertürk et al.   EXPERIMENTAL NEUROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE