Article
Oncology
Eunice Eugenia Robless, Justin Andrew Howard, Ilaria Casari, Marco Falasca
Summary: Extracellular vesicles, particularly exosomes, are key players in intercellular communication, with a specific focus on their role in pancreatic cancer. Long non-coding RNAs (lncRNAs) within these vesicles are of increasing interest as potential biomarkers and therapeutic targets for pancreatic cancer, yet their precise functions within cancer exosomes remain unclear.
Review
Biochemistry & Molecular Biology
Matteo Lulli, Cristina Napoli, Ida Landini, Enrico Mini, Andrea Lapucci
Summary: Non-coding RNAs, especially long non-coding RNAs, have been shown to play critical roles in the initiation, progression, and drug resistance of colorectal cancer. They are emerging as potential therapeutic targets and predictive biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Simone Donati, Cinzia Aurilia, Gaia Palmini, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Pancreatic cancer is a rare and deadly malignancy with low survival rates. Autophagy plays a crucial role in pancreatic cancer progression and drug resistance. Non-coding RNAs have been identified as key regulators of autophagy in pancreatic cancer, indicating their potential as novel therapeutic targets.
Article
Reproductive Biology
Jiao Wang, Xiaocui Zhang, Fei Zheng, Qing Yang, Fangfang Bi
Summary: This study utilized The Cancer Genome Atlas and Reactome databases to retrieve ovarian cancer (OC)-related data and identify mitophagy-related long non-coding RNAs (lncRNAs). A prognostic lncRNA signature was constructed to estimate OC prognosis and therapeutic response. The signature showed that patients in the high-risk group had a poorer prognosis, and a ceRNA network was constructed to explore the potential regulatory mechanisms of lncRNAs.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yu Yan, Danzhu Wu, Liyuan Yang, Jinming Han, Yinglong Liu, Peng Dong, Jing Wu, Xinshuang Yu
Summary: This review summarizes the roles of long non-coding RNAs (lncRNAs) in pancreatic cancer, including their effects on occurrence, development, therapeutic resistance, and potential clinical implications. Understanding the functions and regulatory mechanisms of lncRNAs in pancreatic cancer is of great significance for researchers in developing novel therapeutic strategies.
ADVANCED THERAPEUTICS
(2023)
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Article
Oncology
Saeed Ashrafizaveh, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Husmandi, Amirhossein Zabolian, Md Shahinozzaman, Amir Reza Aref, Michael R. Hamblin, Noushin Nabavi, Francesco Crea, Yuzhuo Wang, Kwang Seok Ahn
Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.
Article
Surgery
Song Meng, Ponnie Robertlee Dolo, Pei Guo, Jian Hong, Chao Li, Xiaocheng Zhu, Dinghua Zhou
Summary: This study investigated the expression of long non-coding RNA LINC01279 in gastric cancer and its relationship with clinicopathological features and prognosis. The results showed that LINC01279 was highly expressed in gastric cancer tissues and serum, and was associated with tumor invasion and prognosis.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Medical Laboratory Technology
Yong-Qiang Gong, Tai-Liang Lu, Fu-Tao Hou, Chao -Wu Chen
Summary: Gastric cancer is a global health problem with high mortality, and its incidence varies significantly across different regions. The interaction between Helicobacter pylori infection and epigenetics plays a crucial role in the occurrence of gastric cancer. Antisense long non-coding RNAs (lncRNAs) have been found to be closely associated with various aspects of gastric cancer. However, a comprehensive compilation and discussion of diverse antisense lncRNAs in gastric cancer is lacking. This review focuses on summarizing the predisposing factors, the interaction between H. pylori and epigenetics in gastric cancer, and the underlying molecular mechanisms and regulatory roles of each antisense lncRNA. Additionally, new insights into the potential diagnosis and treatment of antisense lncRNAs in gastric cancer are provided.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Xin Yang, Minhui Mei, Jingze Yang, Jinlu Guo, Fan Du, Shi Liu
Summary: This study established a prognostic risk model for hepatocellular carcinoma (HCC) based on 17 ferroptosis-related long non-coding RNAs (lncRNAs). The model showed significant prognostic value for HCC and may serve as therapeutic targets associated with ferroptosis in clinical practice.
Review
Oncology
Xiaoge Hu, Xiangxiang Lei, Jinhui Guo, Wen Fu, Wen Sun, Qiliang Lu, Wei Su, Qiuran Xu, Kangsheng Tu
Summary: This article reviews the important role of m6A modification in the development of pancreatic cancer and its molecular mechanism. It has been found that abnormal m6A modification exists in pancreatic cancer tissues and cell lines, and abnormal expressions of m6A regulators and m6A-modified genes are associated with the malignant progression of pancreatic cancer. These findings have potential applications in the clinical diagnosis, prognosis, and therapeutics of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Eduardo E. E. Montalvo-Jave, Natalia Nuno-Lambarri, Guillermo Nahum Lopez-Sanchez, Edwin A. A. Ayala-Moreno, Gabriela Gutierrez-Reyes, Joal Beane, Timothy M. M. Pawlik
Summary: Pancreatic cancer is a lethal disease driven by multiple genetic and epigenetic alterations. Advances in microarray and omics-based sequencing techniques have led to the discovery of novel disease markers, prognostic factors, and therapeutic targets for pancreatic ductal adenocarcinoma (PDAC).
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Vilma Maldonado, Jorge Melendez-Zajgla
Summary: Breast cancer is the leading cause of cancer-related deaths in women worldwide, with mortality rates in the United States stagnant in recent years despite earlier diagnosis and treatment improvements. Long non-coding RNAs (lncRNAs) play a significant role in breast cancer, particularly in the hypoxic response of cancer cells, which may contribute to tumoral progression. This review summarizes the role of hypoxia-associated lncRNAs in cancer hallmarks, their effects on hypoxia signaling pathway, and their potential as diagnostic and prognostic tools.
Article
Oncology
Yufei Yang, Xuebing Yan, Xinxiang Li, Yanlei Ma, Ajay Goel
Summary: Colorectal cancer is a common malignancy with challenges in diagnosis and treatment, and recent research suggests that long non-coding RNAs play important roles in the progression of the disease.
Article
Biochemistry & Molecular Biology
Lei Chen, Ming Fu, Ledong Tan, Jinglu Zhao, Xiaogang Xu, Yuzhen Lin, Qian Zhong, Ruisui Zhong, RuiZhong Zhang, Jixiao Zeng
BIOSCIENCE REPORTS
(2020)
Article
Oncology
Lei Chen, Jingjing Zhang, Qun Chen, Wanli Ge, Lingdong Meng, Xumin Huang, Peng Shen, Hao Yuan, Guodong Shi, Yi Miao, Kuirong Jiang
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Surgery
Dong Xu, Kai Zhang, Mingna Li, J. P. Neoptolemos, Junli Wu, Wentao Gao, Pengfei Wu, Baobao Cai, Jie Yin, Guodong Shi, Zipeng Lu, Kuirong Jiang, Yi Miao
WORLD JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
Yan Qian, Wei Song, Xu Wu, Guowei Hou, Haixiao Wang, Xiao Hang, Tianfang Xia
Summary: The study revealed that DLX6-AS1 plays a crucial regulatory role in GC by targeting miR-4290 and PDK1. Silencing DLX6-AS1 can inhibit tumor growth and aerobic glycolysis, and induce apoptosis in GC cells.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Cell Biology
Wan-Li Ge, Qun Chen, Ling-Dong Meng, Xu-Min Huang, Guo-dong Shi, Qing-Qing Zong, Peng Shen, Yi-Chao Lu, Yi-Han Zhang, Yi Miao, Jing-Jing Zhang, Kui-Rong Jiang
CELL DEATH & DISEASE
(2020)
Article
Oncology
Tianfang Xia, Zhenguo Pan, Jie Zhang
Article
Oncology
Wan-Li Ge, Guo-Dong Shi, Xu-Min Huang, Qing-Qing Zong, Qun Chen, Ling-Dong Meng, Yi Miao, Jing-Jing Zhang, Kui-Rong Jiang
TRANSLATIONAL CANCER RESEARCH
(2020)
Article
Oncology
Ling-Dong Meng, Guo-Dong Shi, Wan-Li Ge, Xu-Min Huang, Qun Chen, Hao Yuan, Peng-Fei Wu, Yi-Chao Lu, Peng Shen, Yi-Han Zhang, Shou-Ji Cao, Yi Miao, Min Tu, Kui-Rong Jiang
Article
Biotechnology & Applied Microbiology
Meng Cao, Peng-Bo Zhang, Peng-Fei Wu, Qun Chen, Wan-Li Ge, Guo-Dong Shi, Jie Yin, Bao-Bao Cai, Shou-Ji Cao, Yi Miao, Kui-Rong Jiang
Summary: DUOX2 may serve as a potential prognostic biomarker and oncogene in PC, associated with clinical outcomes and representing a therapeutic target. Analysis of TFs and miRNA regulatory mechanisms elucidates the functional role of DUOX2 in PC.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu, Kuirong Jiang
Summary: This study found that circSTX6 promotes the proliferation and metastasis of pancreatic ductal adenocarcinoma cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway.
Article
Oncology
Yihan Zhang, Guodong Shi, Lingdong Meng, Jing Wu, Qingqiao Hu, Dong Xv, Kai Zhang, Zipeng Lu, Junlii Wu, Kuirong Jiang
Summary: Malignant pancreatic tumors have aggressive behavior and poor prognosis, requiring prompt surgical treatment. This case report describes a patient who was found to have duodenal lesions during routine gastroscopic examination, and further examination revealed pancreatic lesions and multiple accessory spleens. The postoperative pathological diagnosis indicated an intrapancreatic accessory spleen, highlighting the need for more accurate diagnostic methods to avoid unnecessary surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Dong Xu, Pengfei Wu, Kai Zhang, Baobao Cai, Jie Yin, Guodong Shi, Hao Yuan, Yi Miao, Zipeng Lu, Kuirong Jiang
Summary: This study retrospectively analyzed the surgical outcomes and complication rates of DP-VR and standard DP. The study found that although DP-VR increased the risk of postoperative bleeding and delayed gastric emptying, it was comparable to standard DP in terms of postoperative complications and mortality.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
