Article
Pathology
Lizhong Zeng, Yang Chen, Jingyan Yuan, Xin Lyu, Lei Zhang, Xueli Yan, Ke Mi, Na Li, Fangze Xing, Shuanying Yang
Summary: LMO7DN's low expression in LUAD may serve as a predictor for good prognosis and inhibits cell proliferation by affecting the cell cycle. This study highlights the significant role of LMO7DN in LUAD.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Xu He, Huafu Zhou, Qianyu Huang, Yue Li
Summary: This study developed a prognostic model for lung adenocarcinoma (LUAD) associated with the mitotic cell cycle. The model accurately predicts survival probability at different time points and can be used to evaluate the effectiveness of LUAD treatment. The model is based on clinical and RNA sequencing data, and uses the LASSO-COX algorithm to establish mutant characteristics that predict patient survival. The model also undergoes functional analysis to better understand its involvement in the mitotic cell cycle.
Article
Genetics & Heredity
Yunliang Tang, Yinhong Guo
Summary: A prognostic model for lung adenocarcinoma (LUAD) based on UPS genes (UPSGs) was developed and validated in this study. This model can predict overall and relapsed-free survival and has clinical utility.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Mayukh Banerjee, Kavitha Yaddanapudi, J. Christopher States
Summary: This study demonstrates that environmentally relevant exposure to inorganic arsenic (iAs) can disrupt the cell cycle and induce mitotic accumulation of cells. This effect may be mediated by the displacement of zinc from the RING finger subunit of the anaphase promoting complex/cyclosome (ANAPC11), leading to the stabilization of cyclin B1 and securin. Zinc supplementation can prevent this cell cycle disruption caused by iAs exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Oncology
Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen, Yan Zheng
Summary: SPP1 plays a critical role in promoting cell migration and invasion in lung adenocarcinoma by upregulating COL11A1 expression.
CANCER CELL INTERNATIONAL
(2022)
Article
Genetics & Heredity
Xincheng Zhou, Bing Zou, Jian Wang, Lihong Wu, Qiang Tan, Chunyu Ji
Summary: The expression of INMT is downregulated in non-small-cell lung cancer, especially in lung adenocarcinoma, and is associated with poor overall survival. However, patients with low expression of INMT show favorable clinical benefits to anti-PD-1 treatment. INMT may serve as a valuable independent prognostic biomarker in patients with lung adenocarcinoma.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Ziyan Zhang, Ping Xu, Zhe Hu, Zhaojian Fu, Tongyuan Deng, Xiaojie Deng, Lanzhu Peng, Yingying Xie, Lingzhi Long, Dayong Zheng, Peng Shen, Mengmin Zhang, Bin Gong, Zhibo Zhu, Junhao Lin, Rui Chen, Zhen Liu, Huilin Yang, Rong Li, Weiyi Fang
Summary: CCDC65 is a potential tumor suppressor in lung adenocarcinoma, which can suppress tumor development by inhibiting the cell cycle signal induced by c-Myc/ENO1.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Plant Sciences
Yusheng Zhao, Zhiyong Liu
Summary: Zhang et al. (2023) demonstrated through association analysis that the wheat E3 ubiquitin ligase TaAIRP2-1B positively regulates spike length by involving an upstream regulator, TaERF3, and a downstream target, TaHIPP3. This study provides a deeper understanding of spike architecture regulation and offers an alternative molecular module for designing wheat with increased yield potential.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Medicine, General & Internal
Han Li, You Ge, Zemin Wang, Yangyang Liu, Pingmin Wei
Summary: This study investigates the correlation between neurotransmitter release cycle-related genes and lung adenocarcinoma (LUAD), and finds that they are closely related to the prognosis and immunotherapy selection for LUAD patients.
Article
Biochemistry & Molecular Biology
Hai-Bin Ou, Yan Wei, Yu Liu, Fu-Xiang Zhou, Yun-Feng Zhou
Summary: This study proposes a new immunophenotyping method for evaluating the prognosis and tumor microenvironment cellular infiltration characteristics in lung adenocarcinoma (LUAD) patients and their response to immunotherapy. The results demonstrate that the tumor immune infiltration score is associated with immune activation and apoptosis signaling pathways and can predict patient response to immune checkpoint inhibitors.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Medicine, General & Internal
Sen Zhang, Na Li, Yonghua Yang, Yan Li, Chenshi Lin, Guoquan Fu, Jun Cai
Summary: The study found that high expression of CKAP2 may serve as a marker of poor prognosis in lung adenocarcinoma, and it is not associated with EGFR mutation and ALK rearrangement.
Review
Oncology
Yiying Song, Haiting Liu, Qingqing Xian, Chengzhi Gui, Mingjie Xu, Yunying Zhou
Summary: UHRF1, a multifunctional epigenetic modifier, plays a crucial role in the occurrence and development of cancer. Understanding the regulatory mechanism of UHRF1 in different cancers helps identify targets for inhibiting its expression and function and provides insights for drug research.
Article
Biochemistry & Molecular Biology
Qing Ye, Rehab Mohamed, Duaa Dakhlallah, Marieta Gencheva, Gangqing Hu, Martin C. Pearce, Siva Kumar Kolluri, Clay B. Marsh, Timothy D. Eubank, Alexey V. Ivanov, Nancy Lan Guo
Summary: This study demonstrated that high expression of ZNF71 KRAB is associated with poor survival outcomes in NSCLC patients, as well as with epithelial-to-mesenchymal transition and chemotherapy resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hongsheng Liu, Yingzhi Qin, Na Zhou, Dongjie Ma, Yingyi Wang
Summary: ZNF280A plays a tumor-promoting role in LUAD, with a positive correlation with tumor grade, pathological stage, and lymphatic metastasis, and a negative relationship with patient survival. Its effects on cell proliferation, apoptosis, cell cycle, and cell migration may contribute to the development of LUAD.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Wei Jiang, Jiameng Xu, Zirui Liao, Guangbin Li, Chengpeng Zhang, Yu Feng
Summary: Through analysis of the GSE68465 dataset, we identified 10 LUAC-specific CCRGs and constructed a model. Based on this model, LUAC patients were divided into high- and low-risk groups and the validity was confirmed. Data from CPTAC, HPA, and IHC supported significant dysregulation of these CCRGs in LUAC tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zhenbo Tu, Songping Xie, Meng Xiong, Yinchu Liu, Xiangyong Yang, Kingsley Miyanda Tembo, Jie Huang, Weidong Hu, Xiaoxing Huang, Shan Pan, Pan Liu, Ehtisham Altaf, Ganjun Kang, Jie Xiong, Qiuping Zhang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2017)
Article
Oncology
Songping Xie, Zhenbo Tu, Jie Xiong, Ganjun Kang, Lina Zhao, Weidong Hu, Haiyan Tan, Kingsley Miyanda Tembo, Qianshan Ding, Xinzhou Deng, Jie Huang, Qiuping Zhang
Article
Biochemistry & Molecular Biology
Zhenbo Tu, Jie Xiong, Ruijing Xiao, Liang Shao, Xiangyong Yang, Lu Zhou, Wen Yuan, Meng Wang, Qian Yin, Yingjie Wu, Shan Pan, Jun Leng, Daozi Jiang, Chunjiang He, Qiuping Zhang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell & Tissue Engineering
Zhenbo Tu, Johannes Schmollerl, Benjamin G. Cuiffo, Antoine E. Karnoub
Article
Oncology
Jiaxing Sun, Tian Xie, Muhammad Jamal, Zhenbo Tu, Xinran Li, Yingjie Wu, Jingyuan Li, Qiuping Zhang, Xiaoxing Huang
CANCER CELL INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Zhenbo Tu, Shengqi Hou, Yurong Zheng, Maerjianghan Abuduli, Tamer Onder, Andrew M. Intlekofer, Antoine E. Karnoub
Summary: The metabolic enzyme ALDOA was identified as a driver of cancer cell motility and metastatic colonization, with AMPK playing an essential role in ALDOA-expressing cells. These findings highlight the previously undescribed roles of the ALDOA-AMPK pathway in tumor progression and adverse patient outcomes in various malignancies.
Article
Multidisciplinary Sciences
Fabin Dang, Li Nie, Jin Zhou, Kouhei Shimizu, Chen Chu, Zhong Wu, Anne Fassl, Shizhong Ke, Yuangao Wang, Jinfang Zhang, Tao Zhang, Zhenbo Tu, Hiroyuki Inuzuka, Piotr Sicinski, Adam J. Bass, Wenyi Wei
Summary: Inhibition of CK1 epsilon can prevent acquisition of CDK4/6i resistance, enhancing the therapeutic efficacy of CDK4/6i in human breast cancer.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Zhenbo Tu, Johannes Schmoellerl, Odette Mariani, Yurong Zheng, Yi Hu, Anne Vincent-Salomon, Antoine E. Karnoub
Summary: This study focused on the role of lncRNAs in the development of TNBC, specifically the stimulatory effect of MSCs on the expression of LINC01119 in TNBC cells, leading to accelerated cancer cell growth and tumorigenesis. The findings suggest that the LINC01119-SOCS5 axis may serve as a powerful prognostic indicator of adverse outcomes in TNBC patients and a potential therapeutic target for advanced TNBC management.
Article
Multidisciplinary Sciences
Zhenbo Tu, Yi Hu, Devesh Raizada, Mahmoud A. Bassal, Daniel G. Tenen, Antoine E. Karnoub
Summary: This study discovered that the long noncoding RNA LINC01133 plays a protumorigenic role in triple-negative breast cancer (TNBC) and activates AKT through a mTOR Complex 2 (mTORC2)-dependent pathway in a PI3K-independent manner. The antagonism of LINC01133 weakens cellular growth and is associated with poor patient survival in TNBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyun Bin, Yu Luo, Zefeng Sun, Chaoqun Lin, Peng Huang, Zhenbo Tu, Ling Li, Cong Qu, Jiamin Long, Sufang Zhou
Summary: This study investigated the potential of H2-calponin (CNN2) as a serum biomarker for hepatocellular carcinoma (HCC) using serological analysis and genetic engineering techniques. The HCC group showed a significantly higher positive rate of anti-CNN2 antibody compared to other tumors and normal tissues. The mRNA and protein expressions of CNN2 in cells and tissues were also evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Junying Yuan, Wenyi Wei
Summary: Zhang, Xu, Liu, Wang et al. have discovered that the EGLN1/pVHL-mediated proline hydroxylation inhibits the activity of RIPK1 kinase, but this mechanism is disrupted during prolonged hypoxia, leading to the activation of RIPK1 and consequent cell death and inflammation. The proline hydroxylation of HIF-1α mediated by the EGLN-pVHL pathway is a well-known mechanism for cellular adaptation to hypoxia. The study also reveals that RIPK1, a regulator of TNFR1-mediated cell death, is a target of EGLN1-pVHL, and its proline hydroxylation by EGLN1 suppresses its activation under normoxic conditions.
NATURE CELL BIOLOGY
(2023)
Article
Biochemical Research Methods
Zhenbo Tu, Antoine E. Karnoub
Summary: We present a protocol for cDNA screening to identify genes that promote cancer cell colonization in secondary tissues. Using a proof-of-concept mouse model of pulmonary metastasis, we demonstrate the recovery of colonization-promoting sequences. This approach can be adapted to other cDNA libraries and cancer models to identify intrinsic genetic determinants of metastatic colonization.
Article
Cell & Tissue Engineering
Zhenbo Tu, Johannes Schmollerl, Benjamin G. Cuiffo, Antoine E. Karnoub
