Review
Cell Biology
Laura Vizkeleti, Sandor Spisak
Summary: MYC is a highly deregulated oncogene in cancer, playing a crucial role in cellular processes such as cell cycle and metabolism. Its altered regulation is a hallmark of cancer development, contributing to the rewiring of cellular metabolism and the Warburg effect. Targeting MYC directly is challenging, so understanding its regulatory mechanisms is essential for developing targeted therapies. This review comprehensively summarizes the different forms of MYC oncogenic deregulation and explores potential therapeutic options for MYC-driven tumors.
Review
Cell Biology
Ying-Hao Han, Yuan Wang, Seung-Jae Lee, Mei-Hua Jin, Hu-Nan Sun, Taeho Kwon
Summary: This paper reviews the development of anoikis resistance in metastatic cancer cells and its mediation by external death receptor pathways. The external pathways, particularly caspase-8-dependent mechanisms, appear to play a more crucial role than intrinsic pathways in anoikis regulation. The review discusses the different ligands and death receptors involved in downstream caspase activation and regulation of anoikis, as well as the recruitment of FADD by Fas and TRADD by TNFR1, and DR4- and DR5-associated FADD.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Giuseppina Augimeri, Daniela Bonofiglio
Summary: The breast tumor microenvironment (TME) is recognized as a key player in tumor development and progression for breast cancer patients, with peroxisome proliferator-activated receptor (PPAR) gamma emerging as a potential therapeutic target. Activation of PPAR gamma inhibits breast cancer cell growth and may educate altered stromal cells to counteract inflammation, offering a more efficient way to treat breast cancer.
Review
Biochemistry & Molecular Biology
Goutham Venkata Naga Davuluri, Chia-Hsin Chan
Summary: TAMs can be converted between different functional states through the regulation of cytokines and metabolites in the microenvironment. Dysregulated metabolism plays a crucial role in TAM differentiation and function. Extracellular metabolites within the tumor microenvironment can regulate TAMs through competition for metabolite availability and direct signaling reactions.
Article
Multidisciplinary Sciences
Madhuri Basak, Abhishek Singh Sengar, Kiran Das, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Subhasish Sarkar, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Summary: This study identifies RGS7 as a key driver of chemotherapy-induced oxidative stress, cell loss, and fibrosis in the heart. Importantly, RGS7 does not impact the sensitivity of cancer cells to chemotherapeutic drugs. Therefore, RGS7 emerges as a potential therapeutic target for detecting or mitigating chemotherapy-associated cardiac damage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Keerthi Kurma, Andrea Boizard-Moracchini, Gael Galli, Mickael Jean, Pierre Vacher, Patrick Blanco, Patrick Legembre
Summary: CD95L, known as FasL, is not only involved in apoptosis induction but also triggers non-apoptotic signaling pathways that may promote the aggressiveness of certain diseases. Understanding the role of the soluble form of CD95L in various pathologies could lead to new therapeutic options. Targeting the soluble form of CD95L may be a promising approach in treating inflammatory disorders and cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Li Zhou, Zhe Zhang, Edouard Nice, Canhua Huang, Wei Zhang, Yong Tang
Summary: The circadian rhythm is an essential time-keeping system that regulates the behavior and physiology of all organs. Dysregulated circadian rhythm has been linked to cancer, and understanding the molecular mechanisms of circadian rhythm opens new options for cancer therapy. This review explores the general regulators of circadian rhythms and their impact on cancer, as well as the mechanisms through which disruption of circadian rhythm drives cancer progression. The potential applications of modulating circadian rhythms for cancer treatment are also discussed.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiangyu Zhang, Xinran Wang, Tianxiao Wu, Wenbo Yin, Jiangkun Yan, Yixiang Sun, Dongmei Zhao
Summary: This study provides an extensive review of LSD1 as an important histone demethylase in cancer and its potential applications. The aberrant overexpression of LSD1 in tumor cells is associated with tumor growth, invasion, and metastasis, making it a promising target for cancer therapy. The review summarizes recent advances in LSD1 inhibitors, including their structural characteristics, screening methods, and future directions for development.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Yihui Yang, Liwen Ren, Wan Li, Yizhi Zhang, Sen Zhang, Binbin Ge, Hong Yang, Guanhua Du, Bo Tang, Hongquan Wang, Jinhua Wang
Summary: GABA is a common inhibitory neurotransmitter in the central nervous system of vertebrates, and recent studies have shown its involvement in tumor development and immune regulation. This review summarizes the role of GABAergic signaling in tumor proliferation, metastasis, progression, stemness, and the tumor microenvironment, as well as the underlying molecular mechanisms. The therapeutic advances in targeting GABA receptors for cancer treatment, particularly immunotherapy, are also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pathology
Negar Khoshghamat, Niloufar Jafari, Mehrdad Moetamani-Ahmadi, Ghazaleh Khalili-Tanha, Mohammad-Hossein Khajavi Rad, Saeed Sahebdel, Nima Khalili-Tanha, Saman Soleimanpour, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan
Summary: This article provides an overview of the mechanism of action, prognostic value, and current progress in clinical trials using PD-1/PD-L1 inhibitors in gastrointestinal cancers, as well as the resistant mechanisms underlying the inhibitory effect of these agents.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Immunology
Ryan R. Kowash, Esra A. Akbay
Summary: The adenosine pathway, particularly CD73, is a promising target for cancer immunotherapy, especially in non-small cell lung cancer (NSCLC) where CD73 expression is high. Combining immune checkpoint blockade (ICB) therapies with adenosine pathway inhibitors shows potential for the treatment of lung cancer. Clinical trials exploring the activation of both T and NK cells are in early stages. Understanding the role of CD73 in immune modulation and its intrinsic properties in tumor cells is important for future therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Masoud H. Manjili, Khashayarsha Khazaie
Summary: This thematic issue discusses the mechanisms of tumor dormancy and relapse, highlighting the interactions between malignant cells and other cells in their microenvironment during dormancy. However, a complete understanding of tumor dormancy remains challenging. To discover the pattern of tumor dormancy and relapse, exploring conceptual frameworks and methodological approaches, and focusing on specific biological scales such as mitochondria, are proposed.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Microbiology
Parva R. Thakker, Ardeshir J. Ariana, Stephanie R. Hajjar, David J. Cai, Dikchha R. Rijal, Subash J. Sad
Summary: XIAP is an endogenous inhibitor of cell death and inactivating mutations of XIAP are responsible for X-linked lymphoproliferative disease (XLP-2) and primary immunodeficiency. This study demonstrates that XIAP plays a crucial role in controlling cell death and regulating cytokine secretion during infection with intracellular bacteria. XIAP promotes the fitness and survival of activated CD8 T cells, but its deficiency leads to poor expansion, skewed differentiation, and a failure to control bacterial infection.
Review
Biochemistry & Molecular Biology
Izadora de Souza, Maria Carolina Clares Ramalho, Camila Banca Guedes, Isabeli Yumi Araujo Osawa, Linda Karolynne Seregni Monteiro, Luciana Rodrigues Gomes, Clarissa Ribeiro Reily Rocha
Summary: Glioblastoma multiforme is a lethal disease characterized by drug resistance and evasion of cell death. Ferroptosis, a recently described type of cell death, holds potential as a promising approach for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Nosalova, Alexandra Keselakova, Martin Kello, Miroslava Martinkova, Dominika Fabianova, Martina Bago Pilatova
Summary: Despite the decreasing trend in mortality from colorectal cancer, this study focused on the antiproliferative and pro-apoptotic effects of a compound on colon cancer cells. The compound was found to have concentration-dependent cytotoxic and antiproliferative effects, inducing both intrinsic and extrinsic apoptotic pathways and inhibiting cell migration. These findings suggest the potential of this compound as a future treatment for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)