Article
Biophysics
I. Putu A. Putra, Robert Thomson
Summary: Based on testing and comparing different neck muscle controller methods, this study found that the combined-control approach was less effective than the distributed-control approach or using VCR or CCR systems separately. The results suggest that capturing the VCR reflex is the best choice when investigating whiplash injury mechanisms through FE modeling.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Biomedical
I. Putu A. Putra, Johan Iraeus, Fusako Sato, Mats Y. Svensson, Astrid Linder, Robert Thomson
Summary: The study shows that adding active neck muscles to a human body model can improve head-neck kinematics, with importance placed on mimicking volunteer movements. Optimum gains identified through optimization can be used to describe muscle controllers in experiments.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Mitesh Lalwala, Karan S. Devane, Bharath Koya, Linh Q. Vu, Kevin Dolick, Keegan M. Yates, Nathaniel J. Newby, Jeffrey T. Somers, F. Scott Gayzik, Joel D. Stitzel, Ashley A. Weaver
Summary: Active muscles have a significant impact on postural stabilization and can alter the kinematic response of the human body. In this study, a simplified human body model with active musculature was developed and validated, showing good biofidelity compared to volunteer kinematics. This model will be useful for studying the biomechanics of the human body in scenarios such as vehicle-pedestrian accidents, public transportation braking, and space missions.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
I. Putu Alit Putra, Johan Iraeus, Fusako Sato, Mats Y. Svensson, Robert Thomson
Summary: Previous research lacks satisfactory resource for studying reflexive muscle activity in investigating whiplash motions. This study aimed to develop finite element human body models with active reflexive neck muscles, address the issues in previous models, evaluate the influence of muscle activity features, and select the best model configuration for whiplash injury predictions. The study found that models with active muscle controller and parallel damping elements showed improved head-neck kinematics agreement with volunteers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Matheus A. Correia, Stewart D. McLachlin, Duane S. Cronin
Summary: In this study, a single closed-loop controller for neck muscle activation in a contemporary male Human Body Model (HBM) was developed based on known reflex mechanisms. The study assessed how this approach compared to current open-loop controllers across a range of impact directions and severities. The incorporation of reflex mechanisms using a closed-loop controller showed robust performance for a range of impact directions and severities, which is critical for improving HBM response in automotive impact simulations.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Wei Zeng, Donald R. Hume, Yongtao Lu, Clare K. Fitzpatrick, Colton Babcock, Casey A. Myers, Paul J. Rullkoetter, Kevin B. Shelburne
Summary: This paper presents a framework for modeling 3D deformable muscles to improve musculoskeletal predictions. The framework includes continuum constitutive representation, parametric determination, model validation, fiber distribution estimation, and integration of multiple muscles for joint motion simulation. The study shows the effectiveness and stability of the presented modeling pipeline for simulating complex muscle behavior.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Alvaro Navarrete, Pablo Varela, Miguel Lopez, Claudio M. Garcia-Herrera, Diego J. Celentano, Bernardo Krause
Summary: This study presents a characterization of the active response of the carotid artery of guinea pig fetuses using experiments, modeling, and numerical simulation. The experimental measurements are used to calibrate a coupled mechanochemical model, which accurately describes the influence of smooth cell behavior on the passive and active mechanical response of the vascular tissue. The model is validated and optimized by performing finite element numerical simulations. The main strengths of the model lie in its ability to predict the stationary state of the tissue's active mechanical response through a realistic representation of the mechanochemical process at the cellular level.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Li-Xin Guo, Chi Zhang
Summary: The study developed a human whole-body finite element model to investigate the behavior of the lumbar spine under whole-body vibration, with various validations conducted to ensure the accuracy and validity of the model.
WORLD NEUROSURGERY
(2022)
Article
Computer Science, Interdisciplinary Applications
Gustavo P. Carmo, Mateusz Dymek, Mariusz Ptak, Ricardo J. Alves-de-Sousa, Fabio A. O. Fernandes
Summary: Traumatic brain injuries are a major cause of death and disability worldwide. Finite element head models have been developed to understand the forces and interactions in the human head, offering a cost-effective and ethical alternative to experimental tests. The female finite element head model (FeFEHM) can provide insights into injury mechanisms and neurodegenerative diseases.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Engineering, Biomedical
Prasannaah Hadagali, Steven L. Fischer, Jack P. Callaghan, Duane S. Cronin
Summary: In this study, a new muscle-based repositioning method was compared to traditional applied BCs in a finite element (FE) neck model. The muscle-based method improved the kinematic and kinetic responses and led to differences in tissue-level responses compared to the conventional BC method.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Olivia L. Bruce, W. Brent Edwards
Summary: Females have a higher risk of stress fractures than males, possibly due to sex-related differences in tibial geometry leading to increased bone strain. This study validated previous findings by comparing tibia-fibula bone geometry, density, and finite element-predicted bone strain in a new cohort. It found that females had higher bone density and narrower tibial diaphysis, resulting in greater bone strain and increased fracture risk.
Article
Ophthalmology
Somaye Jafari, Yongtao Lu, Joseph Park, Joseph L. Demer
Summary: A finite element model was developed to simulate ocular rotation induced by active contraction of extraocular muscles, with or without tethering by the optic nerve. Physiologically plausible tensions and deformations of the EOMs during incremental adduction were analyzed, revealing the biomechanical behavior of the muscles in relation to the optic nerve.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Tian-Cheng Li, Chun-Jie Liu, Song-Yang Liu, Xin Wang, Jing-Jing Feng, Ju-Tao Wang, Cheng-Fei Du
Summary: The effects of muscle activation on the dynamic responses of the pilot's neck during simulated emergency ejections were investigated using a validated finite element model. Three muscle activation curves were designed to simulate different activation times and levels. Muscle pre-activation reduced fluctuations in neck rotation angles, while continuous activation increased both rotational angle and load on the intervertebral disc. Pre-activation had a protective effect on the neck, while continuous activation increased axial load and rotation angle.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Engineering, Biomedical
Marco Palanca, Sara Oliviero, Enrico Dall'Ara
Summary: The study validated the predictions of micro finite element models for local displacement of intact and metastatic vertebrae using experimental Digital Volume Correlation measurements. Results showed that simplified models can predict complex displacement fields in the elastic regime with high reliability, but more complex nonlinear models should be implemented for regions with high deformation beyond yield point.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Robin Remus, Sascha Selkmann, Andreas Lipphaus, Marc Neumann, Beate Bender
Summary: This paper presents a muscle-driven hybrid finite element and multibody model for the study of spinal stability. The model achieves high accuracy, demonstrates agreement with in vivo data in biomechanical responses under simulated loads, and provides an effective estimation tool.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)