期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 31, 期 16, 页码 2094-2113出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1793872
关键词
Surgical cotton; cellulose microfibrils; citric acid; gelatin; tissue engineering
资金
- Ministry of Human Resource Development
Cellulose, a polysaccharide of beta (1-4) linked D-glucose units, is a cheap, eco-friendly and most abundant natural polymer on this planet. Among various cellulosic materials, cotton cellulose is readily available, lignin-free, FDA approved, and widely used in the medical field because of its higher degree of biocompatibility and non-cytotoxic nature. Though cotton cellulose showed essential material properties for scaffold design, the least priority had been given to this material. The present study aimed at exploring the fabrication of scaffold using cotton microfibers for bone tissue engineering application. The study also aimed at improving the mechanical, physio-chemical and osteogenic properties of the microfibrous scaffold by crosslinking with citric acid and further modified with gelatin. FTIR indicated some interactions between cellulose, citric acid and gelatin within the scaffolds, while XRD results demonstrated the crystalline nature of scaffolds. Porosity and swelling studies demonstrated that all scaffolds are hydrophilic and porous. The microporous interconnected network of scaffolds was confirmed by FESEM. FESEM micrographs and MTT assay confirmed that all scaffolds were nontoxic to MG 63. Based on findings, it was concluded that gelatin coated cotton cellulose microfibers crosslinked with citric acid scaffold would be a potential template for bone tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据