Article
Microbiology
Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B. DeOliveira, Jutamas Shaughnessy, Lisa A. Lewis, Peter A. Rice, Par Comstedt, Sanjay Ram
Summary: A safe and effective vaccine is urgently needed to combat multidrug-resistant Neisseria gonorrhoeae. In this study, a platform called EDEN was used to screen 26 potential vaccine antigens, and their efficacy was tested in a mouse model. The combination of NGO1549 and NGO0265 showed significant reduction in colonization by MDR strains.
Article
Immunology
Kathryn A. Matthias, Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, Margaret C. Bash
Summary: Recent studies have found that Neisseria meningitidis vaccines lacking specific proteins can provide protection against Neisseria gonorrhoeae infections in mice, and the antibodies produced can cross-react with N. gonorrhoeae. This finding supports the development of a cross-protective vaccine against Neisseria infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Priyal Bagwe, Lotika Bajaj, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Smital Patil, Sharon Vijayanand, Rikhav Gala, Martin J. D'Souza, Susu M. Zughaier
Summary: There is a concerning increase in global gonorrhea cases, as the bacteria causing the infection has developed antimicrobial resistance. This study explores the immunogenicity of a potential gonorrhea vaccine in mice using dissolving microneedles. The vaccine formulation showed promising results in inducing humoral, cellular, and protective immune responses against gonococcal infection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Microbiology
Eve Bernet, Marthe Lebughe, Antony T. Vincent, Mohammad Mehdi Haghdoost, Golara Golbaghi, Steven Laplante, Annie Castonguay, Frederic J. Veyrier
Summary: The study suggests that a boron-based salt, sodium tetraphenylborate (NaBPh4), displays high bactericidal activity against Neisseria meningitidis and Neisseria gonorrhoeae, with limited impact on closely related commensal species. The drug candidate's target(s) are likely located intracellularly or within the cell envelope, and mutants with decreased susceptibility show reduced virulence. This narrow selectivity of NaBPh4 is observed to have potential therapeutic importance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Salah A. Sheweita, Amro A. Amara, Heba Gamal, Amany A. Ghazy, Ahmed Hussein, Mohammed Bahey-El-Din
Summary: This study successfully produced well-structured Pseudomonas aeruginosa ghosts using different chemical concentrations. Oral immunization with these ghosts induced immune responses in diabetic rats, promoting antibody production and enhancing cellular immune responses, ultimately protecting the rats from PA infection.
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran
Summary: Coumarins were shown to inhibit bacterial alpha-carbonic anhydrases from Neisseria gonorrhoeae and Vibrio cholerae, with the nature and position of substituents in the coumarin ring strongly influencing the inhibitory efficacy. In comparison, human CA isoforms hCA I and II were less prone to inhibition by these compounds, indicating potential for coumarin bacterial CA inhibitors with selectivity for bacterial over human isoforms.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Randa H. Ali, Mohamed E. Ali, Reham Samir
Summary: This study developed a novel chemical protocol to produce Neisseria meningitidis ghost vaccine. The vaccine candidate showed both safety and immunogenicity. In animal model, it induced a significantly higher humoral immune response and better serum bactericidal assay values compared to the commercial vaccine. However, clinical studies are needed to further evaluate its effectiveness.
Article
Microbiology
Delia Onorini, Cory Ann Leonard, Regenia Phillips Campbell, Barbara Praehauser, Theresa Pesch, Robert V. Schoborg, Ann E. Jerse, Bernadetta Tarigan, Nicole Borel
Summary: Chlamydia trachomatis and Neisseria gonorrhoeae are commonly reported bacterial sexually transmitted disease agents. However, the co-infection of C. trachomatis and N. gonorrhoeae is not well studied. This study aimed to investigate the reactivation of latent C. muridarum infection with N. gonorrhoeae in mice. The results showed that N. gonorrhoeae did not reactivate latent C. muridarum shedding, suggesting that the interaction between C. trachomatis and N. gonorrhoeae may depend on actively replicating C. trachomatis in the genital tract.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Eunbyeol Ko, Soyoung Jeong, Min Yong Jwa, A. Reum Kim, Ye-Eun Ha, Sun Kyung Kim, Sungho Jeong, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Summary: The study showed that compared to h-SP or f-SP vaccine, r-SP vaccine can provide higher protection against S. pneumoniae, enhance specific antibody levels, and promote follicular helper T cell activation.
Article
Immunology
Michael W. Russell
Summary: Pelvic inflammatory disease and infertility can often develop in females after Neisseria gonorrhoeae infection, but identifying the exact causative agent is challenging due to the lack of definitive immunological tests. The extensive antigenic variability of N. gonorrhoeae and its manipulation of the human immune system are key factors in understanding the pathogenesis and improving diagnostic methods for these conditions.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Umairah Natasya Mohd Omeershffudin, Suresh Kumar
Summary: The escalating problem of Neisseria gonorrhoeae and its antibiotic resistance is a major global health crisis. Effective management strategies are urgently needed to prevent severe consequences. This review provides valuable insights for combating antibiotic resistance by elucidating the multifaceted aspects of this global challenge.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Anne F. Luetkemeyer, Deborah Donnell, Julia C. Dombrowski, Stephanie Cohen, Cole Grabow, Clare E. Brown, Cheryl Malinski, Rodney Perkins, Melody Nasser, Carolina Lopez, Eric Vittinghoff, Susan P. Buchbinder, Hyman Scott, Edwin D. Charlebois, Diane V. Havlir, Olusegun O. Soge, Connie Celum
Summary: In this study, it was found that doxycycline postexposure prophylaxis significantly reduced the incidence of sexually transmitted infections (STIs) among MSM and transgender women. The use of doxycycline was shown to be effective in preventing STIs in this population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Shuaijie Song, Shuyi Wang, Xiaoyun Jiang, Fan Yang, Shuai Gao, Xu'ai Lin, Hao Cheng, Stijn van der Veen
Summary: The study found that CpG1826 is the optimal Th1-polarizing adjuvant and when combined with MtrE and Loop2 as vaccine antigens, it can generate strong Th1-polarized and bactericidal antibody responses. The vaccine can provide protection against gonococcal infections and accelerate the clearance of already established infections.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath, Elizabeth Miller
Summary: The study found no significant difference in anti-pertussis IgG concentrations in infants born to mothers vaccinated with TdaP(5)-IPV or TdaP(3)-IPV. However, infants born to unvaccinated mothers had lower anti-pertussis toxin IgG concentrations, which normalized by 13 months of age.
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Gabriele Costantino, Daniel P. Flaherty, Claudiu T. Supuran
Summary: The inhibition of alpha-class carbonic anhydrases (CAs) from bacterial pathogens by phenols and phenolic acids was investigated. Small changes in the phenol scaffold led to drastic effects on the inhibitory activity of bacterial CA. This underinvestigated class of bacterial CA inhibitors may have potential in fighting drug resistant bacteria.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)