Article
Neurosciences
Victoria Fleming, Brian C. Helsel, Lauren T. Ptomey, H. Diana Rosas, Benjamin Handen, Charles Laymon, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Florence Lai, Sharon Krinsky-McHale, Shahid Zaman, Beau M. Ances, Joseph H. Lee, Sigan L. Hartley
Summary: This study aimed to determine if unintentional weight loss is part of Alzheimer's disease (AD) in adults with Down syndrome (DS). The results showed that unintentional weight loss is associated with A beta deposition and occurs prior to the onset of AD dementia in DS, indicating that it may be a useful sign of AD in this population.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Emily S. Brook, Zachary J. D'Alonzo, Virginie Lam, Dick C. Chan, Satvinder S. Dhaliwal, Geraldb F. Watts, John C. L. Mamo, Ryusuke Takechi
Summary: Background: Obesity is associated with Alzheimer's disease (AD). Studies show that low plasma amyloid-beta (A beta) 42/40 ratio implies increased AD risk. However, the relationship between body mass index (BMI) and plasma A beta has not been thoroughly studied. Objective: We investigated if high BMI is linked to altered plasma A beta levels and whether reducing BMI through calorie-restriction could normalize A beta concentrations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Seo Young Kang, Ye-Jee Kim, Wooyoung Jang, Ki Young Son, Hye Soon Park, Young Sik Kim
Summary: This study found that changes and variability in body mass index have an impact on the risk of Alzheimer's disease, especially in women. Appropriate weight management is recommended to prevent AD.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Shiqi Yuan, Wentao Wu, Wen Ma, Xiaxuan Huang, Tao Huang, Min Peng, Anding Xu, Jun Lyu
Summary: This study found a nonlinear relationship between BMI and AD risk in participants aged 60 years or older, with lower BMI being associated with higher AD risk and higher BMI being associated with lower AD risk. Participants with high genetic risk for AD and low BMI were associated with the highest AD risk. In addition, a bidirectional Mendelian randomization analysis revealed a reverse causality between BMI and AD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sung Hoon Kang, Jong Hyuk Kim, Yoosoo Chang, Bo Kyoung Cheon, Yeong Sim Choe, Hyemin Jang, Hee Jin Kim, Seong-Beom Koh, Duk L. Na, Kyunga Kim, Sang Won Seo
Summary: This study investigated the association between BMI changes and variability with Aβ deposition in a non-demented population and found that decreased or increased BMI as well as greater BMI variability were associated with a greater risk of Aβ positivity.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Summary: Longitudinal imaging studies in adults with Down syndrome identified A beta accumulation trajectories and early accumulation sites; A beta(-) group, A beta converters, and A beta (+) group showed differences in A beta(L) change; Model images and A beta(L) change values can better identify subthreshold A beta accumulation in DS.
Editorial Material
Neurosciences
Karel Kostev
Summary: In this study, the researchers found an important association between body mass index and dementia risk, specifically highlighting the difference between males and females. Underweight was found to be strongly associated with dementia risk in men but not in women.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Ji Young Kang, Kyungdo Han, Mee Kyoung Kim
Summary: There is a known association between underweight and non-tuberculous mycobacterial pulmonary disease (NTM-PD). This study found that as the severity of underweight increased, the risk of NTM-PD also increased proportionally.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Seunghoon Lee, Min Soo Byun, Dahyun Yi, Min Jung Kim, Joon Hyung Jung, Nayeong Kong, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Summary: Low BMI in late-life may predict or contribute to the progression of tau pathology over the subsequent years in cognitively unimpaired older adults.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Keun You Kim, Junghee Ha, Jun-Young Lee, Eosu Kim
Summary: Using nationwide cohort data, this study explored the relationship between loss in body mass index (BMI) or waist circumference (WC) and risk of dementia, and found that BMI loss increased the risk of all-cause dementia and Alzheimer's disease in participants without obesity, but not in participants with obesity. WC loss was only associated with decreased Alzheimer's disease risk in participants with obesity.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Joakim Bastrup, Kathrine H. Hansen, Thomas B. G. Poulsen, Kenneth Kastaniegaard, Ayodeji A. Asuni, Soren Christensen, Dorthe Belling, Lone Helboe, Allan Stensballe, Christiane Volbracht
Summary: Chronic treatment with aducanumab significantly reduces the number of senile plaques in AD mouse model and alters the proteomic profile of surrounding tissue, potentially inhibiting Aβ toxicity and increase cell viability.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Ariane G. Bollack, Hugh G. E. Pemberton, Lyduine E. Collij, Pawel M. Markiewicz, David M. Cash, Gill Farrar, Frederik Barkhof
Summary: This review summarizes the current design and methodologies of longitudinal PET studies, utilizing positron emission tomography to quantify amyloid and tau pathology. The intrinsic variability of AD protein load over time and technical factors contributing to PET measurement uncertainty are detailed. Suggestions for mitigating these factors, including leveraging shared information between serial scans, are provided.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Yeonjung Ha, Young Eun Chon, Ju Ho Lee, Seong Gyu Hwang
Summary: This study investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC). The results showed that both incident and persistent general and central fatness were associated with an increased risk of HCC. This emphasizes the importance of preventing and reversing body fatness to reduce the incidence of HCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Shizuo Hatashita, Daichi Wakebe
Summary: This study found that some initially amyloid-negative non-demented subjects converted to globally amyloid-positive during a long-term follow-up, with some association with the APOE epsilon 4 allele. Early regional increases in PIB DVR were most frequently observed in the right lateral temporal cortex.
Article
Public, Environmental & Occupational Health
Kamaluddin Latief, Dieta Nurrika, Min-Kuang Tsai, Wayne Gao
Summary: There is an association between obesity and the risk of stroke and heart disease, especially in middle-aged adults. These findings suggest that reducing BMI through healthy dietary habits and increased physical activity, particularly among middle-aged adults with higher education, occupational employment, and residence in urban or rural areas, may be beneficial in preventing stroke and heart disease.
Review
Peripheral Vascular Disease
Ya-Nan Ou, Chen-Chen Tan, Xue-Ning Shen, Wei Xu, Xiao-He Hou, Qiang Dong, Lan Tan, Jin-Tai Yu
Review
Behavioral Sciences
Yi Qu, He-Ying Hu, Ya-Nan Ou, Xue-Ning Shen, Wei Xu, Zuo-Teng Wang, Qiang Dong, Lan Tan, Jin-Tai Yu
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Clinical Neurology
Wei Xu, Lan Tan, Bing-Jie Su, Huan Yu, Yan-Lin Bi, Xiao-Fang Yue, Qiang Dong, Jin-Tai Yu
ALZHEIMERS & DEMENTIA
(2020)
Article
Neurosciences
Wei Xu, Wei Feng, Xue-Ning Shen, Yan-Lin Bi, Ya-Hui Ma, Jie-Qiong Li, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: The study found that minimal depressive symptoms are associated with cognitive impairments and Alzheimer's disease risk, with amyloid pathology playing a partial mediating role. Additionally, longitudinal analyses revealed a bidirectional relationship between depressive symptoms and amyloid pathology.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Clinical Neurology
Jin-Tai Yu, Wei Xu, Chen-Chen Tan, Sandrine Andrieu, John Suckling, Evangelos Evangelou, An Pan, Can Zhang, Jianping Jia, Lei Feng, Ee-Heok Kua, Yan-Jiang Wang, Hui-Fu Wang, Meng-Shan Tan, Jie-Qiong Li, Xiao-He Hou, Yu Wan, Lin Tan, Vincent Mok, Lan Tan, Qiang Dong, Jacques Touchon, Serge Gauthier, Paul S. Aisen, Bruno Vellas
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Geriatrics & Gerontology
Wei Xu, Chen-Chen Tan, Xi-Peng Cao, Lan Tan
Summary: The study found that PGRN and neuroinflammatory markers increased over the course of Alzheimer's disease, and neuroinflammation can modulate the association of PGRN with amyloid pathologies. Neuroinflammatory markers significantly modulated the relationship between amyloid burden and CSF PGRN, which could predict cognitive decline and lower AD risk in certain groups.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Ya-Yu Wang, Yi-Jun Ge, Chen-Chen Tan, Xi-Peng Cao, Lan Tan, Wei Xu
Summary: Among non-demented community-dwellers, the global average proportion of APOE4 carriers was 23.9%, varying significantly by geographical regions and ethnic groups. APOE4 carriers are common in communities, especially in Africans and Caucasians, emphasizing the need for precision medicine strategies in high-risk populations in the future.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Wei Xu, Chen-Chen Tan, Juan-Juan Zou, Xi-Peng Cao, Lan Tan
Summary: Insomnia may modulate the relationship between amyloid-beta and cognitive performance in older adults, with individuals having elevated A beta and insomnia experiencing faster cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Lin Li, Wei Xu, Chen-Chen Tan, Xi-Peng Cao, Bao-Zhen Wei, Cheng-Wen Dong, Lan Tan
Summary: This study found that long-term omega-3 supplementation may have a positive role in preventing AD in genetically at-risk populations, especially showing significant effects in APOE ε4 carriers. The relationship between omega-3 use and memory function, cerebral amyloid burden, and AD risk may be influenced by the mediation of amyloid pathologies, brain reserve capacities, and brain metabolism.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Geriatrics & Gerontology
Chun-Yan Guo, Zhen Sun, Chen-Chen Tan, Lan Tan, Wei Xu
Summary: Frailty in late life is a promising risk factor for cognitive disorders, especially physical, cognitive, and biopsychosocial frailty are associated with the development of cognitive decline or dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
Yi-Ming Huang, Wei Xia, Yi-Jun Ge, Jia-Hui Hou, Lan Tan, Wei Xu, Chen-Chen Tan
Summary: This study found that a rational sleep duration of 7.5 hours per night is associated with a reduced risk of cardio-cerebrovascular disease in adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Bao-Zhen Wei, Lin Li, Cheng-Wen Dong, Chen-Chen Tan, Wei Xu
Summary: This study aimed to assess the longitudinal relationships between omega-3 fatty acid intake and blood biomarkers with the risk of Alzheimer's disease, dementia, or cognitive decline. The findings showed that long-term use of omega-3 fatty acid supplements reduced the risk of Alzheimer's disease by 64%. A meta-analysis of multiple studies also indicated that dietary intake of omega-3 fatty acids could lower the risk of dementia or cognitive decline, particularly for docosahexaenoic acid (DHA) intake.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Clinical Neurology
Han Li, Chen-Chen Tan, Lan Tan, Wei Xu
Summary: This study aimed to summarize predictors of cognitive deterioration (CD) among individuals with subjective cognitive decline (SCD) through a systematic review and meta-analysis. The results identified several factors, including age at onset, stable SCD, self- and informant-reported SCD, worry, and SCD in the memory clinic, as predictors of CD. These findings can contribute to the early identification and management of high-risk populations to delay dementia onset.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
H. -c. Chi, Y. Liu, C. -c. Tan, Y. -c. Zhang, L. Tan, Wei Xu
Summary: This study aimed to evaluate the associations between renal diseases and blood markers with the risk of dementia or cognitive decline among non-demented adults. The results showed that acute kidney injury, chronic kidney disease, higher serum creatinine, higher urine albumin creatinine ratio, and lower estimated glomerular filtration rate were associated with an increased risk of dementia or cognitive decline.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
