期刊
JOURNAL FRANCAIS D OPHTALMOLOGIE
卷 43, 期 7, 页码 E217-E230出版社
MASSON EDITEUR
DOI: 10.1016/j.jfo.2020.05.002
关键词
Trabecular meshwork; Glaucoma; Intraocutar pressure; Ocular hypertension; Iridocorneat angle; Trabecutar meshwork cells; Aqueous humor; Primary open angle glaucoma; Secondary glaucoma; Steroid-induced glaucoma; Pigmentary glaucoma; Pseudoexfoliative glaucoma; Glaucoma medications; Trabeculoplasty; Glaucoma surgery
Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, three-dimensional structure composed of trabecular meshwork cells (TMC) interdigitated into a muttilayered organization within the extracetlutar matrix (ECM). The purpose of this literature review is to provide an overview of current understanding of the trabecular meshwork and its pathophysiology in glaucoma. Thus, we will present the main anatomical and cellular bases for the regulation of aqueous humor outflow resistance, the pathophysiological mechanisms involved in trabecular dysfunction in the various types of glaucoma, as well as current and future therapeutic strategies targeting the trabecular meshwork. (C) 2020 Elsevier Masson SAS. All rights reserved.
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