Article
Chemistry, Applied
Ran Yang, Lei Fang, Jia Li, Yong-Qing Zhang
Summary: A new lignan and three known compounds were isolated from Lonicerae Japonicae Flos, with one compound showing significant anti-inflammatory activity by inhibiting a specific release reaction.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kuei-Hung Lai, Yu-Li Chen, Mei-Fang Lin, Mohamed El-Shazly, Yu-Chia Chang, Po-Jen Chen, Chun-Han Su, Yen-Chun Chiu, Amina M. Illias, Chih-Chuan Chen, Lo-Yun Chen, Tsong-Long Hwang
Summary: The study found that the ethanol extract of Lonicerae japonicae flos has anti-inflammatory effects on human neutrophils activated by fMLF, suggesting its potential application in daily health care during the COVID-19 pandemic.
Article
Pharmacology & Pharmacy
Lifei Gu, Xueqing Xie, Bing Wang, Yibao Jin, Lijun Wang, Guo Yin, Jue Wang, Kaishun Bi, Tiejie Wang
Summary: In this study, a chemical pattern recognition model was established based on ultra-high performance liquid chromatography (UHPLC) and anti-SARS-CoV2 activity to analyze the quality of Lonicerae japonicae flos and Lonicerae flos. A total of 11 characteristic components were identified and could be recommended as quality control markers. The established model effectively differentiated between Lonicerae japonicae flos and Lonicerae flos, providing a feasible tool for quality assessment of natural products and reference for quality standard setting.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Senwang Zheng, Songtao Liu, Ajiao Hou, Song Wang, Yexin Na, Jianhua Hu, Hai Jiang, Liu Yang
Summary: Lonicerae Japonicae Flos has been used for over 1,500 years as a tea and medicine with functions of clearing heat and detoxification. It has various pharmacological actions, including anti-inflammatory, antiviral, and antibacterial effects. Further research is needed for the comprehensive evaluation of its quality and understanding of multi-target network pharmacology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Ruifang Hua, Yan Ding, Xiaolong Liu, Bingxuan Niu, Xinfeng Chen, Jingjing Zhang, Kerui Liu, Pei Yang, Xiaofei Zhu, Jintao Xue, Hui Wang
Summary: Lonicerae Japonicae Flos (LJF) has anti-viral, anti-oxidative, and anti-inflammatory properties, and this study demonstrates its potential in treating sleep disorders related to sleep deprivation and neuro-inflammation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kaishuang Liu, Yibao Jin, Lifei Gu, Meifang Li, Ping Wang, Guo Yin, Shuhong Wang, Tiejie Wang, Lijun Wang, Bing Wang
Summary: H-1-NMR spectroscopy combined with chemical pattern recognition was used to analyze samples of Lonicerae japonicae flos with different species, growth modes, and processing methods. Linear discriminant analysis (LDA) showed good classification abilities for distinguishing the samples based on species, growth modes, and processing methods. The study also identified the main differential components and explored the potential compounds for distinguishing cultivated and wild Lonicerae japonicae flos.
Article
Chemistry, Medicinal
Yu Gao, Feng-xue Wang, Qing Liu, Yao-dong Qi, Qiu-ling Wang, Hai-bo Liu
Summary: Lonicerae Japonicae Flos and Lonicerae Flos exhibit high similarity in treating inflammation, sharing many core targets and biological functions, making them interchangeable in clinical treatment. Organic acids are the main compounds responsible for their anti-inflammatory effects.
CHINESE HERBAL MEDICINES
(2021)
Article
Plant Sciences
Xiaorong Su, Zhen-hua Zhu, Lin Zhang, Qian Wang, Ming-ming Xu, Cai Lu, Yue Zhu, Jianguo Zeng, Jin-Ao Duan, Ming Zhao
Summary: Lonicerae Japonicae Caulis possesses anti-inflammatory properties, with the main contribution coming from its isochlorogenic acid-rich and biflavonoid-rich fractions. The main components, isochlorogenic acids A and C, as well as ochnaflavone, are primarily responsible for the anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuting Liang, Mingjun Liu, Yanghai Wang, Lu Liu, Yan Gao
Summary: A sensitive and accurate quantitative method was established and applied to determine the 15 ingredients of LJF in RSV-infected mice plasma. The pharmacokinetic study showed that LJF had a positive effect on the treatment of RSV infection. Isochlorogenic acid B, isochlorogenic acid C, secoxyloganin, chlorogenic acid, and loganic acid were speculated to be the main effective ingredients of LJF in treating RSV.
Article
Biochemical Research Methods
Zhichen Cai, Chengcheng Wang, Cuihua Chen, Lisi Zou, Chuan Chai, Jiali Chen, Mengxia Tan, Xunhong Liu
Summary: The study developed a comprehensive method using ultra-fast liquid chromatography-tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) coupled with multivariate statistical analysis for quality evaluation of Lonicerae Japonicae Flos and Lonicerae Flos, revealing differential components.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Xueqing Xie, Lifei Gu, Wanyi Xu, Xiean Yu, Guo Yin, Jue Wang, Yibao Jin, Lijun Wang, Bing Wang, Tiejie Wang
Summary: This study identified six bioactive compounds in Lonicerae japonicae flos and established chemical pattern recognition models for quality evaluation. The results showed that the cultivation pattern significantly affected the anti-influenza effect of Lonicerae japonicae flos, with the wild variety exhibiting higher effectiveness. Additionally, there was no significant difference in quality among Lonicerae japonicae flos samples with different processing methods and geographical origins.
Article
Plant Sciences
Wei Mu, Lan-hui Zhang, Wei Jiang, Tian Zhang, An Liu, Yong-qiang Zhang, Jun Zhao, Lei Shi, Lin-na Liu
Summary: Lonicerae japonicae flos (LJF) and its main component chlorogenic acid (CGA) have the potential to prevent vascular endothelial dysfunction induced by abdominal radiotherapy, possibly through increasing the expression of GTPCH1/BH4/eNOS signaling pathway.
Article
Integrative & Complementary Medicine
Pan Hui-Qin, Zhou Heng, Miao Shui, Guo De-An, Zhang Xiao-Li, Hu Qing, Mao Xiu-Hong, Ji Shen
Summary: The overuse and misuse of pesticides can lead to variations in herbal medicine ingredients, which has prompted attention in the medicinal field as an alternative medicine form. This study systematically explored the effects of two frequently used insecticides on the comprehensive constituents of Lonicerae Japonicae Flos, resulting in the identification of 29 metabolic markers.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Yang-Qiannan Tang, Li Li, Tian-Feng Lin, Li-Mei Lin, Ya-Mei Li, Bo-Hou Xia
Summary: In this study, a model for discriminating LJF and LF was established and applied in the discrimination of their related prescriptions. The results showed good accuracy and applicability, suggesting that this method is a rapid and effective tool for the successful discrimination of LJF and LF and their related prescriptions.
Article
Engineering, Multidisciplinary
Pengdi Cui, Yang Yu, Jing Zhao, Peiqi Miao, Qilong Xue, Changqing Liu, Zheng Li
Summary: Hyperspectral imaging was used to investigate the drying process of Lonicerae Japonicae Flos extract, providing information on the morphology and moisture content changes of droplets. The Faster R-CNN algorithm located and identified the target droplets, while the PLS and ANN algorithms established a moisture content prediction model, with the ANN showing better accuracy.
Article
Nanoscience & Nanotechnology
Yan Zhao, Fang Lu, Yue Zhang, Meiling Zhang, Yusheng Zhao, Juan Luo, Hui Kong, Huihua Qu
Summary: This study identifies that carbon dots (CS-CDs) in cigarette mainstream smoke may have anti-anxiety and sedative effects by decreasing glutamate levels, promoting norepinephrine production, and reducing dopamine levels in mice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Jie Hu, Juan Luo, Meiling Zhang, Jiashu Wu, Yue Zhang, Hui Kong, Huihua Qu, Guoliang Cheng, Yan Zhao
Summary: RSFC-CDs with diameters ranging from 2-3 nm primarily exert gastric protective effects by reducing the levels of NF-kappa B, TNF-alpha, IL-6, SOD, CAT, GSH-Px, GSH, MDA, and iNOS to inhibit ethanol-induced inflammation and oxidative stress, demonstrating their potential for application in ethanol-induced gastric injury.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yifan Zhang, Jie Zhao, Yusheng Zhao, Xue Bai, Yumin Chen, Yuhan Liu, Yue Zhang, Hui Kong, Huihua Qu, Yan Zhao
Summary: As an autoimmune disease, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, show potential as a new treatment for UC. The use of carbonized rhei radix rhizoma (RRR) and extracted CDs (RRR-CDs) display significant anti-ulcerative activity in a UC mouse model. This suggests that RRR-CDs could be a candidate drug for UC treatment, expanding the understanding of the biological activity of CDs and providing a potential solution for difficult clinical diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Fang Lu, Yurong Ma, Hui Huang, Yue Zhang, Hui Kong, Yan Zhao, Huihua Qu, Qingguo Wang, Yang Liu, Zhenhui Kang
Summary: Research has found that semi-carbonized nanodots prepared from natural plants show good effectiveness in the treatment and inhibition of stress gastric ulcers, reducing inflammation and oxidative stress, protecting the gastric mucosa, and regulating neuroendocrine responses, energy metabolism, and intestinal flora structure, thereby alleviating the occurrence of stress-induced gastric ulcers.
Article
Nanoscience & Nanotechnology
Yusheng Zhao, Yue Zhang, Hui Kong, Meiling Zhang, Jinjun Cheng, Jiashu Wu, Huihua Qu, Yan Zhao
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)