期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 23, 期 4, 页码 363-369出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00674-15
关键词
-
资金
- University of Minnesota Foundation
- University of Minnesota International Center for Antiviral Research and Epidemiology
- Division of Intramural Research, National Institute of Dental and Craniofacial Research
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing antibodies in the same individuals before, during, and after primary EBV infection have not been reported. We studied antibody responses to EBV in college students who acquired primary EBV infection during prospective surveillance and correlated the kinetics of antibody response with the severity of disease. Neutralizing antibodies and enzyme-linked immunosorbent assay (ELISA) antibodies to gp350, the major target of neutralizing antibody, reached peak levels at medians of 179 and 333 days after the onset of symptoms of infectious mononucleosis, respectively. No clear correlation was found between the severity of the symptoms of infectious mononucleosis and the peak levels of antibody to individual viral proteins or to neutralizing antibody. In summary, we found that titers of neutralizing antibody and antibodies to multiple EBV proteins increase over many months after primary infection with EBV.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据