Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice through Endoplasmic Reticulum Stress and Unfolded Protein Response

Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response

(2019) Erawan Borkham-Kamphorst et al.   CELLULAR SIGNALLING

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice

(2016) Yan Cai et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease

(2016) Verena Wieser et al.   JOURNAL OF HEPATOLOGY

Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2

(2016) Dewei Ye et al.   JOURNAL OF HEPATOLOGY

Lipocalin 2 Upregulation Protects Hepatocytes from IL1-β-Induced Stress

(2015) Ying Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

(2015) Xu Xu et al.   HEPATOLOGY

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

(2015) Ming-Jiang Xu et al.   HEPATOLOGY

The carbon tetrachloride model in mice

(2015) D Scholten et al.   LABORATORY ANIMALS

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

(2014) Gisela Campos et al.   ARCHIVES OF TOXICOLOGY

Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver

(2014) Anastasia Asimakopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis

(2013) Erawan Borkham-Kamphorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CHOP-mediated hepcidin suppression modulates hepatic iron load

(2013) Katrin Mueller et al.   JOURNAL OF PATHOLOGY

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis

(2012) Erawan Borkham-Kamphorst et al.   LIVER INTERNATIONAL

Stress management at the ER: Regulators of ER stress-induced apoptosis

(2012) Adrienne M. Gorman et al.   PHARMACOLOGY & THERAPEUTICS

Lipocalin-2 (LCN-2) is a Major Acute Phase Protein in a Rat and Mouse Model of Sterile Abscess

(2012) Sadaf Sultan et al.   SHOCK

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

(2011) Chunbin Zhang et al.   HEPATOLOGY

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation

(2011) Erawan Borkham-Kamphorst et al.   LIVER INTERNATIONAL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

(2010) Sophie C. Cazanave et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Signaling cell death from the endoplasmic reticulum stress response

(2010) Gordon C Shore et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling

(2010) Kim   INTERNATIONAL JOURNAL OF ONCOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL