Article
Oncology
Luo Chen, Yiu Chun Chiang, Lai Sheung Chan, Wai Yin Chau, Maria Li Lung, Michael Kahn, Kwok Wai Lo, Nai Ki Mak, Hong Lok Lung
Summary: Metastatic nasopharyngeal carcinoma (NPC) is an incurable disease and the main cause of NPC-related deaths. This study investigates the anti-metastatic activity of the CBP/beta-catenin Wnt antagonist, IGC-001, in NPC. The results show that ICG-001 treatment reduces the adhesion, migration, and invasion capabilities of NPC cells, which are closely associated with distant metastasis. MiR-134 is consistently upregulated by ICG-001 treatment and its overexpression inhibits cancer cell adhesion, migration, and invasion. Furthermore, miR-134 downregulates integrin beta 1 (ITGB1), a key factor in cell adhesion and migration. The study demonstrates that modulation of the Wnt signaling pathway by ICG-001 can effectively inhibit NPC metastasis through the miR-134/ITGB1 axis.
Article
Cell Biology
Xinping Chen, Weihua Xu, Zhichao Ma, Juan Zhu, Junjie Hu, Xiaojuan Li, Shengmiao Fu
Summary: This study revealed that circ_0000215 is overexpressed in NPC and exerts oncogenic effects by regulating the miR-512-5p/PIK3R1 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Oncology
Sheng-Hui Lan, Shu-Ching Lin, Wei-Chen Wang, Yu-Chan Yang, Jenq-Chang Lee, Pei-Wen Lin, Man-Ling Chu, Kai-Ying Lan, Roberto Zuchini, Hsiao-Sheng Liu, Shan-Ying Wu
Summary: The study revealed a novel mechanism in which autophagy utilizes the miR-449a-LEF1-cyclin D1 axis to suppress colorectal cancer tumorigenesis. The findings suggest that miR-449a has the potential to be a prognostic biomarker for colorectal cancer patients and open avenues for prognosis and treatment by manipulating the autophagy-miR-449a axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Binlin Cai, Xiu Qu, Dan Kan, Yi Luo
Summary: This study found that miR-26a-5p can regulate the growth and invasion ability of nasopharyngeal carcinoma cells by inhibiting PTGS2. This is of great significance for a better understanding of the pathogenesis and development of nasopharyngeal carcinoma.
Article
Cell Biology
Yajie Zhao, Chao Li, Yan Zhang, Zhanzhan Li
Summary: CircTMTC1 is highly expressed and miR-495 is downregulated in nasopharyngeal carcinoma (NPC), which are associated with poor prognosis. CircTMTC1 promotes NPC progression through targeting miR-495 and activating the MET-eIF4G1 translational regulation axis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Wanpeng Li, Hanyu Lu, Huan Wang, Xianhui Ning, Quan Liu, Huankang Zhang, Zhuofu Liu, Jingjing Wang, Weidong Zhao, Yurong Gu, Houyong Li, Xicai Sun, Li Hu, Dehui Wang
Summary: In this study, it was found that miR-107 plays a crucial role in promoting proliferation and migration of NPC cells, while circTGFBR2 acts as a sponge for miR-107, leading to upregulation of TGFBR2 expression and suppression of NPC progression. These findings suggest that circTGFBR2 could serve as a novel tumor suppressive factor and potential therapeutic target for NPC patients.
Article
Oncology
Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Summary: miR-449a-5p inhibits CM proliferation by targeting CDK6, which provides a potential molecular target for preventing myocardial injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Feng Ying Zhang, Xia Li, Ting Ting Huang, Mei Ling Xiang, Lin Lin Sun, Zhao Lan Sun
Summary: LINC00839 is highly expressed in nasopharyngeal carcinoma (NPC), and its attenuation can reduce the aggressive properties of NPC cells by directly sponging miR-454-3p and regulating c-Met expression.
Article
Cell Biology
Shaosheng Liu, Yuanyuan Li, Zhaoxia Li
Summary: The study found that Salidroside can significantly inhibit the proliferation and promote apoptosis of nasopharyngeal carcinoma (NPC) cells by regulating the miR-4262/GRP78 signaling axis.
Article
Biology
Mingyu Zhang, Bowen Zhang, Xiaohan Wang, Jiahang Song, Ming Tong, Zheng Dong, Jiaonan Xu, Meng Liu, Yuan Jiang, Ning Wang, Ying Wang, Zhimin Du, Yanyan Liu, Rong Zhang, Chaoqian Xu
Summary: In this study, a novel long non-coding RNA called CFAR was found to be a profibrotic factor in the heart, promoting cardiac fibrosis through the miR-449a-5p/LOXL3/mTOR axis. CFAR may serve as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Peilin Zhong, Aihua Guo, Linhua Wang, Xiurong Lin, Mei Feng
Summary: This study aimed to investigate the effect of circRNA CDK6 (circCDK6) on the development and biological behavior of cervical cancer. The results showed that circCDK6 expression level significantly increased in various cervical cancer cells. MiR-449a was identified as a potential target of circCDK6, and silencing circCDK6 led to increased expression of miR-449a. CircCDK6 participated in tumorigenesis and cancer progression and potentially functioned as a tumor suppressor in cervical cell progression through the Epithelial-Mesenchymal Transition (EMT) process by regulating miR-449a.
Article
Biotechnology & Applied Microbiology
Wei Cao, Yi Sun, Long Liu, Junwei Yu, Jiabiao Ji, Yatang Wang, Jianming Yang
Summary: This study investigated the role of HOTAIR in drug resistance in nasopharyngeal carcinoma (NPC). It was found that upregulated expression of HOTAIR in NPC tissues and cells was associated with cisplatin resistance. Knockdown of HOTAIR increased cell sensitivity to cisplatin and reduced cell viability, chemoresistance-related protein expression, migration, invasion, and induced cell apoptosis. In addition, downregulation of miR-106a-5p expression and upregulation of SOX4 expression were observed in cisplatin-resistant NPC tissues and cells. HOTAIR regulated the miR-106a-5p/SOX4 axis to enhance drug resistance in NPC cells.
Article
Oncology
Bing Liao, Yun Yi, Lei Zeng, Zhi Wang, Xinhua Zhu, Jianguo Liu, Bingbin Xie, Yuehui Liu
Summary: Accumulating evidence suggests that LINC00667 plays a role in promoting malignant phenotypes in nasopharyngeal carcinoma by competitively binding to miR-4319 to upregulate FOXQ1 expression, thereby affecting cell proliferation, migration, and invasion. This study identifies LINC00667 as a potential diagnostic and therapeutic target for NPC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Josephine Mun Yee Ko, Hoi Yan Ng, Ka On Lam, Keith Wan Hang Chiu, Dora Lai Wan Kwong, Anthony Wing Ip Lo, Jean Chrysei Wong, Roger Chia Wei Lin, Henry Chun Hung Fong, Jason Ying Ki Li, Wei Dai, Simon Law, Maria Li Lung
Review
Hematology
Alexander M. Grandits, Rotraud Wieser
Summary: Relapse in acute myeloid leukemia (AML) is associated with therapy resistance and likely results from the accumulation of therapy-refractory leukemic stem cells, as well as genetic and transcriptional changes. While targeted drugs have been approved, chemotherapy remains the mainstay of AML therapy. Studies have shown consistently altered gene expression between diagnosis and relapse of AML, suggesting potential for novel targeted drugs development.
EXPERIMENTAL HEMATOLOGY
(2021)
Article
Oncology
Josephine Mun Yee Ko, Shiu Yeung Lam, Lvwen Ning, Annie Wai Yeeng Chai, Lisa Chan Lei, Sheyne Sta Ana Choi, Carissa Wing Yan Wong, Maria Li Lung
Summary: Unbiased whole-exome sequencing identified RAD50 as a potential cancer predisposition gene in familial esophageal squamous cell carcinoma (ESCC). Two pathogenic RAD50 protein truncation variants were found to significantly increase familial ESCC risk, with functional characterization suggesting a dominant-negative effect on DNA repair and sensitization to cell death. The study provides novel insights into potential therapeutic options for RAD50 variants and CHK1 inhibitors in ESCC.
Article
Oncology
Jian Li, Josephine Mun-Yee Ko, Wei Dai, Valen Zhuoyou Yu, Hoi Yan Ng, Jean-Sebastien Hoffmann, Maria Li Lung
Summary: High expression of POLQ in esophageal squamous cell carcinoma is associated with unfavorable prognosis, contributing to malignant phenotypes through promoting genome stability, suggesting it as a potential therapeutic target.
Article
Oncology
Ya-Nan Tan, Yong-Peng Li, Jian-Dong Huang, Min Luo, Shan-Shan Li, Anne Wing-Mui Lee, Fu-Qiang Hu, Xin-Yuan Guan
Summary: The introduction of cationic thermosensitive lipid nanoparticles IR780/DPPC/BMS can enhance the spatial distribution of TILs in TME and improve the antigen-presenting ability of DCs, activating cytotoxic T lymphocytes and reversing tumor immunosuppression state.
Article
Biochemistry & Molecular Biology
Alexander Michael Grandits, Sophie Bromberger, Gerwin Heller, Barbara Andrea Reinoehl, Erwin Tomasich, Klaudia Schossleitner, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser
Summary: Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor prognosis. EVI1, a novel oncogene, promotes cellular proliferation and invasiveness in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wai-Tong Ng, Cheuk-Wai Choi, Barton But, Roger K. C. Ngan, Stewart Tung, Ashley C. Cheng, Dora L. W. Kwong, Tai-Xiang Lu, Anthony T. C. Chan, Harry Yiu, Sarah Lee, Frank Wong, Kam-Tong Yuen, Richard J. Chappell, Anne W. M. Lee
Summary: The combination of cisplatin-based induction or adjuvant chemotherapy with concurrent chemoradiotherapy has been found to improve overall survival in patients with locoregionally advanced nasopharyngeal carcinoma. The optimal platinum doses for the concurrent and induction/adjuvant phases were determined to be 160 mg/m(2) and 260 mg/m(2) respectively.
CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Oncology
Wai-Tong Ng, Melvin L. K. Chua, Anne W. M. Lee
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Sik-Kwan Chan, Brian O'Sullivan, Shao Hui Huang, Tin-Ching Chau, Ka-On Lam, Sum-Yin Chan, Chi-Chung Tong, Varut Vardhanabhuti, Dora Lai-Wan Kwong, Chor-Yi Ng, To-Wai Leung, Mai-Yee Luk, Anne Wing-Mui Lee, Horace Cheuk-Wai Choi, Victor Ho-Fun Lee
Summary: This study identified a potential new subdivision of de novo M1 nasopharyngeal carcinoma patients based on anatomic characteristics and pre-treatment plasma EBV DNA. The new prognostic groups showed improved survival prediction and risk stratification, indicating a more precise and personalized approach to treatment. Further validation of these stage subdivisions in other institutions is needed to confirm the results.
Review
Oncology
James C. H. Chow, Anne W. M. Lee, Charlene H. L. Wong, Wai Tong Ng, Zhiwei Liu, Joshua K. Tay, Kwok Seng Loh, Pia Pace-Asciak, Oded Cohen, June Corry, Juan Pablo Rodrigo, Raymond K. Y. Tsang, Fernando Lopez, Nabil F. Saba, Remco de Bree, Alfio Ferlito
Summary: In endemic areas of nasopharyngeal carcinoma (NPC), individuals with a positive family history (FH+) and positive Epstein-Barr virus (EBV) status have a higher risk of developing NPC. Familial screening using EBV serology may aid in the early detection of NPC.
Article
Oncology
Josephine Mun Yee Ko, Ka On Lam, Dora Lai Wan Kwong, Ian Yu-Hong Wong, Fion Siu-Yin Chan, Claudia Lai-Yin Wong, Kwan Kit Chan, Tsz Ting Law, Keith Wan Hang Chiu, Candy Chi Shan Lam, Jean Chrysei Wong, Henry Chun Hung Fong, Faith Sin Fai Choy, Andy Lo, Simon Law, Maria Li Lung
Summary: Esophageal cancer is a aggressive disease with low survival rates. Circulating tumor cells (CTCs) can be used as predictive and prognostic biomarkers for therapeutic responses and disease progression. Longitudinal CTC monitoring can provide useful information for prediction of treatment efficacies and disease progression, and it can be used as a non-invasive liquid biopsy for supplementary information with clinical imaging.
Review
Medicine, Research & Experimental
Michael King Yung Chung, Lanqi Gong, Dora Lai-Wan Kwong, Victor Ho-Fun Lee, Ann Wing-Mui Lee, Xin-Yuan Guan, Ngar-Woon Kam, Wei Dai
Summary: Most mature B cells can be classified into four subtypes based on surface markers IgD and CD27. DN B cells, although present in small numbers, are crucial in various diseases, playing different roles depending on the disease. Further understanding of the mechanisms underlying DN B cell involvement in these diseases is essential for therapeutic strategies.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Luo Chen, Wai Yin Chau, Hei Tung Yuen, Xiao Han Liu, Robert Zhong Qi, Maria Li Lung, Hong Lok Lung
Summary: This study showed that THY1 suppresses tumor invasion in NPC through the formation of adherens junctions and inhibition of SRC and canonical Wnt signaling. PTPN22 was identified as a key factor in THY1-mediated inhibition of cell invasion and SRC activity. PDGF-Rb and SRC were identified as potential drug targets for suppressing NPC metastasis.