期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms21155447
关键词
extracellular matrix; decellularization; regenerative medicine
资金
- Spanish Programa Estatal de I+D+i Orientada a los Retos de la Sociedad [RTI2018-101708-A-I00]
- Fomento de San Sebastian innovative talent programme [0508/2019/0009]
- Spanish State Training Subprogramme [PRE2018-084542]
- Spanish State Subprogramme of Incorporation Ramon y Cajal [RYC2018-025502-I]
- 2019 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation [IN[19]_CMA_BIO_0119]
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. This review provides an overview of the most common methods used to obtain the dECM and summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide for future research development.
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