Article
Multidisciplinary Sciences
Patrick Hanna, Ashok Khatri, Shawn Choi, Severine Brabant, Matti L. Gild, Marie L. Piketty, Bruno Francou, Dominique Prie, John T. Potts Jr, Roderick J. Clifton-Bligh, Agnes Linglart, Thomas J. Gardella, Harald Juppner
Summary: This study found that a homozygous mutation in PTH leads to abnormal processing of its precursor sequence, resulting in the inability to activate cells. Commercial assays were unable to accurately detect the presence of this variant in patient plasma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Federico Nicoli, Giorgia Dito, Gregorio Guabello, Matteo Longhi, Sabrina Corbetta
Summary: Hypercalciuria in postmenopausal women with osteoporosis may lead to kidney stones and various degrees of impaired parathyroid hormone secretion. Thiazide diuretics efficiently reduce urine calcium excretion, contributing to an increase in bone mineral density.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Elena Tsourdi, Athanasios D. Anastasilakis
Summary: Pregnancy involves enhanced intestinal calcium absorption, while lactation involves additional calcium obtained through resorption from the maternal skeleton, leading to reversible bone loss. These maternal adaptations during pregnancy and lactation can affect or complicate the presentation, diagnosis, and management of parathyroid disorders.
Article
Endocrinology & Metabolism
Anda Mihaela Naciu, Gaia Tabacco, John P. Bilezikian, Assunta Santonati, Daniela Bosco, Giosue Giordano Incognito, Gianluigi Gaspa, Silvia Manfrini, Alberto Falchetti, Pierpaolo Trimboli, Gherardo Mazziotti, Nicola Napoli, Gianfranco Sanson, Roberto Cesareo, Fabio Vescini, Andrea Palermo
Summary: This study evaluated the therapeutic advantage of calcium citrate (Ca-Cit) compared to calcium carbonate (CaCO3) in hypoparathyroidism, and found that Ca-Cit may have a potential beneficial effect on reducing the risk of nephrolithiasis. Additionally, Ca-Cit was associated with less constipation symptoms compared to CaCO3.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Medicine, General & Internal
Dalal S. Ali, Karel Dandurand, Aliya A. Khan
Summary: Close monitoring and adjustment of doses of calcium and active vitamin D are recommended during pregnancy to maintain serum calcium levels in the normal range for women with hypoparathyroidism. Hyper- and hypocalcemia should be avoided in order to reduce maternal and fetal complications during pregnancy and lactation in patients with hypoparathyroidism. Standard therapy with elemental calcium, active vitamin D, and vitamin D is safe during pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Stine Linding Andersen, Jesper Karmisholt, Peter Vestergaard, Lise Husted, Stine Krogh Veno, Peter Astrup Christensen
Summary: Comparisons of different assay methods for parathyroid hormone (PTH) revealed variations in results and reference ranges. When switching from the second- to the third-generation PTH assay, lower levels were observed with the third-generation method, and method-specific reference ranges were established.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Jessica Costa-Guda, Kristin Corrado, Justin Bellizzi, Elizabeth Saria, Kirsten Saucier, Miriam Guemes-Aragon, Guntas Kakar, Madison Rose, Melanie Pascal, Cynthia Alander, Sanjay M. Mallya, Andrew Arnold
Summary: This study found that vitamin D deficiency may not increase the incidence of parathyroid tumors, but it may accelerate the growth of existing tumors.
Article
Multidisciplinary Sciences
Shin Tokunaga, Takehisa Kawata
Summary: Evocalcet, a novel calcimimetic agent, has less gastrointestinal adverse effects compared to cinacalcet. In this study using miniature pigs, it was found that cinacalcet induced vomiting while evocalcet did not, and cinacalcet significantly increased vagus nerve action potentials compared to evocalcet. However, the increase in vagus nerve action potentials after administration of evocalcet was not significantly different from that after cinacalcet treatment.
Review
Biochemistry & Molecular Biology
Guido Zavatta, Paola Altieri, Giulia Vandi, Valentina Vicennati, Uberto Pagotto, Fabio Vescini
Summary: New insights into phosphate metabolism present challenges for endocrinologists to rethink pathophysiology. Studying rare mineral metabolism diseases can provide valuable new information about phosphate and other minerals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jens Bollerslev, Evelina Sjostedt, Lars Rejnmark
Summary: PTH plays a crucial role in regulating calcium and phosphate balance in adults, with various clinical manifestations and cardiovascular risks associated with parathyroid disorders. While most PHPT patients are asymptomatic, they still face cardiovascular risks; Ps-HypoPT patients show resistance to PTH with unclear CV risks; HypoPT patients often develop hormonal deficiency syndrome post-surgery, leading to increased CV risk.
ANNALES D ENDOCRINOLOGIE
(2021)
Article
Biochemistry & Molecular Biology
Mirjana Babic Leko, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Calciotropic hormones, PTH and calcitonin, play crucial roles in bone mineral metabolism and calcium-phosphate homeostasis. Environmental and genetic factors can influence their levels, with smoking, BMI, exercise, and micronutrients showing significant associations with PTH levels. Similarly, exposure to heavy metals like cadmium can also affect PTH levels. Research on the impact of environmental factors on calcitonin levels is limited, with smoking being the most clearly associated lifestyle factor with increased calcitonin levels. Additional studies are needed to better understand how environmental factors can affect PTH and calcitonin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Magdalena Basinska-Lewandowska, Andrzej Lewinski, Krzysztof C. Lewandowski, Elzbieta Skowronska-Jozwiak
Summary: This study found that elevated PTH concentrations in the setting of normocalcemia in spring are more likely to be caused by 25OHD deficiency rather than nPHPT, while increased PTH concentrations in autumn are more likely to reflect nPHPT.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Romagnoli, Roberto Zonefrati, Elena Lucattelli, Marco Innocenti, Roberto Civinini, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study evaluated the effects of PTH on the proliferation and differentiation of skeletal muscle satellite cells isolated from human biopsies. Results showed no significant changes in cAMP and proliferation in the isolated cells treated with PTH, but differentiated myotubes treated with PTH exhibited increased cAMP, expression of myogenic differentiation genes, and MHC protein. This study provides new insights into the effects of PTH on human skeletal muscle cells and opens new avenues for research in muscle pathophysiology.
Article
Biochemistry & Molecular Biology
Lorenzo Sanesi, Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Flavia Pugliese, Carla Columbu, Vincenzo Carnevale, Silvia Tunnera, Alfredo Scillitani, Maria Grano, Graziana Colaianni, Silvia Colucci
Summary: The study aimed to evaluate the effect of vitamin D supplementation on irisin serum levels in PHPT patients and conducted related experiments in cells. The results showed that vitamin D supplementation significantly increased irisin serum levels in PHPT patients, and in cells, vitamin D could regulate the expression of Fndc5/irisin by up-regulating Sirt1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Maria Fusaro, Luciano Pereira, Jordi Bover
Summary: Chronic kidney disease (CKD) is a major public health concern associated with significant morbidity and mortality. Secondary hyperparathyroidism (SHPT) is a common comorbidity of CKD, characterized by high levels of parathyroid hormone (PTH) in the blood. CKD-MBD, which includes mineral metabolism disturbances and bone disorders, is considered as part of the definition of CKD. It is a complex condition involving dysregulation of bone turnover, mineralization, growth, strength, as well as vascular or soft-tissue calcification. This increases the risk of fractures, cardiovascular disease, and overall mortality in CKD-MBD patients. Monitoring serum markers is crucial for diagnosing SHPT and CKD-MBD, and there are different markers for late-stage kidney disease patients receiving dialysis and non-dialysis CKD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Giovanni Lombardi, Edgard Delvin
Summary: Osteoporosis is a prevalent bone disease and circulating microRNAs have shown potential as diagnostic and prognostic markers. However, the lack of standardization and harmonization of methods limits their application.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Neurosciences
Ramin Mahdipour, Alireza Ebrahimzadeh-Bideskan, Mahmoud Hosseini, Sara Shahba, Giovanni Lombardi, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: Neurological disorders have a significant impact on global health, and grape seed extract shows potential as a valuable therapeutic agent due to its antioxidant, anti-inflammatory, and protein homeostasis maintenance properties.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Ewa Aleksandra Rodziewicz-Flis, Malgorzata Kawa, Jan Jacek Kaczor, Marzena Szaro-Truchan, Damian Jozef Flis, Giovanni Lombardi, Ewa Ziemann
Summary: The study aimed to evaluate the impact of folk-dance and balance training on physical performance, insulin resistance, and blood pressure in older adults. Both training programs effectively improved physical performance and blood pressure, accompanied by changes in selected exerkines. Folk-dance training also enhanced insulin sensitivity.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
L. Cianferotti, C. Cipriani, S. Corbetta, G. Corona, G. Defeudis, A. G. Lania, C. Messina, N. Napoli, G. Mazziotti
Summary: Endocrine diseases can lead to osteoporosis and fractures, but traditional bone density measurement methods may not accurately capture skeletal alterations caused by endocrine disorders. Therefore, it is important to use new techniques to assess bone quality for the diagnosis and prediction of skeletal fragility and fracture risk.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Paola Maroni, Marta Gomarasca, Giovanni Lombardi
Summary: Long non-coding RNAs (lncRNAs) have potential as biomarkers for early cancer diagnosis, prognosis, and therapeutic targets. Bone metastasis is a common progression of advanced cancers, particularly breast, prostate, and lung cancers. Understanding the pathophysiology of bone metastasis and improving clinical management are challenging but important areas of research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Summary: This study found that osteocalcin (OC), a bone matrix protein, can modulate the function of parathyroid tumor cells by activating the calcium sensing receptor (CASR). OC reduces the activity of pERK/ERK and increases the levels of active beta-catenin through CASR activation. It also affects the expression of related genes to influence the physiological functions of parathyroid tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Carlotta Mondadori, Amit Chandrakar, Silvia Lopa, Paul Wieringa, Giuseppe Talo, Silvia Perego, Giovanni Lombardi, Alessandra Colombini, Matteo Moretti, Lorenzo Moroni
Summary: The study investigated the ability of scaffold architecture to modulate macrophage polarization. The rhombus architecture was found to promote the release of certain cytokines by M2a macrophages, which may have a positive impact on the healing process.
BIOACTIVE MATERIALS
(2023)
Review
Cell Biology
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali, Giovanni Lombardi
Summary: The locomotor system, consisting of skeletal muscles and bones, plays a vital role in maintaining function and preventing frailty. As individuals age, chronic disorders of the locomotor system may arise, negatively impacting bone and muscle function. Senescent cells, which accumulate in muscle tissue with advancing age or under pathological conditions, impair muscle regeneration and contribute to muscle weakness. Additionally, senescence in the bone microenvironment affects bone turnover, increasing the risk of osteoporosis. Understanding the mechanisms underlying cellular senescence in musculoskeletal tissues may aid in developing effective biomarkers for early detection of tissue flaws.
AGEING RESEARCH REVIEWS
(2023)
Article
Medical Laboratory Technology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: The main objective of this study was to assess 25-(OH)DF, vitamin D metabolites, and VMRs in inactive men and athletes. The results showed that regular long-term physical activity had no effect on the concentration of vitamin D metabolites at rest. Furthermore, free vitamin D did not correlate more strongly with vitamin D metabolites and VMRs compared to total.
CLINICA CHIMICA ACTA
(2023)
Article
Physiology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: Novel markers of vitamin D status, such as free 25-(OH)D and the vitamin D metabolite ratio, show seasonal rhythms in athletes, while markers of psychophysical stress and free 25-(OH)D do not exhibit clear rhythmicity. Additionally, strong correlations exist between vitamin D metabolites in different training periods.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babinska, Katarzyna Micielska, Malgorzata Zychowska, Giovanni Lombardi, Jedrzej Antosiewicz, Ewa Ziemann
Summary: The study showed that regular Nordic Walking training with additional resistance improved cognitive functions and physical performance in older adults. These positive effects were associated with a reduced BDNF concentration and kynurenine-to-tryptophan ratio as well as changes in the amino acid profile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Federico Pennestri, Giuseppe Banfi
Summary: The Italian Government plans to invest euro15 billion of European funds to digitalize the National Health Service and enhance primary care. Telemedicine is considered a key innovation to achieve these goals, but no details are given on how digitalization and remote care technologies should be implemented. This paper focuses on the contribution of digitalization and telemedicine to primary care innovations, drawing from implemented technology-driven policies. These policies can significantly benefit from digitalization and remote care technology, provided that risks and limitations are considered.
Article
Nutrition & Dietetics
Matteo Briguglio, Thomas W. Wainwright, Giovanni Lombardi
Summary: Accurately identifying malnourished patients in surgical research can enhance the prediction of postoperative recovery potential, utilizing literature-based equations built on historical data to classify patients is essential for efficient studies.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, Research & Experimental
Fabien D. Legrand, Benoit Dugue, Joe Costello, Chris Bleakley, Elzbieta Miller, James R. Broatch, Guillaume Polidori, Anna Lubkowska, Julien Louis, Giovanni Lombardi, Francois Bieuzen, Paolo Capodaglio
Summary: Whole-body cryotherapy is a non-pharmacological treatment that influences inflammatory events and has various benefits, such as improved sleep quality, faster neuromuscular recovery, and chronic pain relief. It may also have positive effects on mental health and cognitive functions. There have been concerns about its safety, but these concerns are often based on misunderstandings regarding the differences between whole-body cryotherapy and partial-body cryotherapy. This article reviews the literature and concludes that the safety risks associated with whole-body cryotherapy are within acceptable limits and can be prevented by following existing recommendations and guidelines.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Physiology
Jacopo A. Vitale, Stefano Borghi, Maria Francesca Piacentini, Giuseppe Banfi, Antonio La Torre
Summary: This study investigated the sleep characteristics of elite track-and-field athletes and found significant differences in sleep patterns between sexes and among different disciplines. Female athletes had better sleep quality, while sleep-hygiene strategies had a positive impact on athletes' sleep parameters.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
