MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

(2020) Charles E. Evans et al.   ACTA NEUROPATHOLOGICA

Role of PDGF-A-Activated ERK Signaling Mediated FAK-Paxillin Interaction in Oligodendrocyte Progenitor Cell Migration

(2019) Juhi Singh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of Metabotropic Glutamate Receptors in Neurological Disorders

(2019) Rosalia Crupi et al.   Frontiers in Molecular Neuroscience

Pharmacological antagonism of histamine H2R ameliorated L-DOPA–induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD

(2019) Mohamed Rafiuddin Ahmed et al.   NEUROBIOLOGY OF AGING

Galectin-1 attenuates neurodegeneration in Parkinson’s disease model by modulating microglial MAPK/IκB/NFκB axis through its carbohydrate-recognition domain

(2019) Yi Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats

(2018) Camila de Ávila et al.   BEHAVIOURAL BRAIN RESEARCH

Sex-specific differences in cannabinoid-induced extracellular-signal-regulated kinase phosphorylation in the cingulate cortex, prefrontal cortex, and nucleus accumbens of Lister Hooded rats

(2018) Michela Rosas et al.   BEHAVIOURAL PHARMACOLOGY

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice

(2018) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells

(2018) Wei Xiong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

(2018) Katherine L. Gibbs et al.   Cell Death & Disease

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis

(2018) Androniki Raftogianni et al.   Frontiers in Molecular Neuroscience

Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons

(2018) Hector Albert-Gasco et al.   Brain Structure & Function

Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer

(2018) Arancha Botella-López et al.   Brain Structure & Function

ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson’s Disease

(2018) Sumit Sarkar et al.   CURRENT NEUROVASCULAR RESEARCH

Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling

(2018) Miho TERUNUMA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice

(2018) Charles E. Evans et al.   NEUROBIOLOGY OF AGING

Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway

(2017) Joseph Vithayathil et al.   HIPPOCAMPUS

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial memory

(2017) M. Haidar et al.   HIPPOCAMPUS

Microglia in prion diseases

(2017) Adriano Aguzzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of oxytocin and vasopressin neuron activity in rat hypothalamic paraventricular nucleus by relaxin-3-RXFP3 signalling

(2017) Alan Kania et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dorsal and Ventral Hippocampus Differentiate in Functional Pathways and Differentially Associate with Neurological Disease-Related Genes during Postnatal Development

(2017) A-Ram Lee et al.   Frontiers in Molecular Neuroscience

Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory

(2016) Héctor Albert-Gascó et al.   Brain Structure & Function

Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus

(2016) Alexander Dee et al.   DEVELOPMENT

Signaling pathways controlling activity-dependent local translation of BDNF and their localization in dendritic arbors

(2016) Gabriele Baj et al.   JOURNAL OF CELL SCIENCE

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

(2016) Ya Wen et al.   PLoS One

Roles of microglia in brain development, tissue maintenance and repair

(2015) Mackenzie A. Michell-Robinson et al.   BRAIN

Pea3 determines the isthmus region at the downstream of Fgf8-Ras-ERK signaling pathway

(2015) Hidekiyo Harada et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

(2015) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Differential Activation of Mitogen-Activated Protein Kinases, ERK 1/2, p38MAPK and JNK p54/p46 During Postnatal Development of Rat Hippocampus

(2015) Ana Paula Costa et al.   NEUROCHEMICAL RESEARCH

Familial Amyotrophic Lateral Sclerosis

(2015) Kevin Boylan   NEUROLOGIC CLINICS

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

(2015) Magdalena Cieślik et al.   PLoS One

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

(2015) Shinya Yufune et al.   Scientific Reports

Characterizing autism spectrum disorders by key biochemical pathways

(2015) Megha Subramanian et al.   Frontiers in Neuroscience

Long-Term Social Recognition Memory Is Mediated by Oxytocin-Dependent Synaptic Plasticity in the Medial Amygdala

(2014) Rotem Gur et al.   BIOLOGICAL PSYCHIATRY

Neurogenesis in the septal and temporal part of the adult rat dentate gyrus

(2014) Chryssa Bekiari et al.   HIPPOCAMPUS

NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons

(2014) Amelia Stanco et al.   NEURON

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

(2014) Ronald R Seese et al.   NEUROPSYCHOPHARMACOLOGY

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

(2014) W.N. Yang et al.   NEUROSCIENCE

Heme oxygenase-1 protects against Alzheimer’s amyloid-β1-42-induced toxicity via carbon monoxide production

(2014) N Hettiarachchi et al.   Cell Death & Disease

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

(2014) Craig M. Smith et al.   Frontiers in Pharmacology

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease

(2013) Manish Verma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comparative dynamics of MAPK/ERK signalling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and retrieval

(2013) Besnard Antoine et al.   Brain Structure & Function

Hierarchical scaffolding of an ERK1/2 activation pathway

(2013) Susanne Vetterkind et al.   Cell Communication and Signaling

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells

(2013) Keiko Nonomura et al.   DEVELOPMENTAL CELL

Cellular and molecular mechanisms controlling the migration of neocortical interneurons

(2013) Oscar Marín   EUROPEAN JOURNAL OF NEUROSCIENCE

Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

(2013) Sherie Ma et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers

(2012) Ksenia Z. Meyza et al.   BEHAVIOURAL BRAIN RESEARCH

Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides

(2012) Despina E. Ganella et al.   BEHAVIOURAL PHARMACOLOGY

Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex

(2012) K. Y. Kwan et al.   DEVELOPMENT

Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat

(2012) Charlotte K. Callaghan et al.   HIPPOCAMPUS

Extinction of Aversive Memories Associated with Morphine Withdrawal Requires ERK-Mediated Epigenetic Regulation of Brain-Derived Neurotrophic Factor Transcription in the Rat Ventromedial Prefrontal Cortex

(2012) W.-S. Wang et al.   JOURNAL OF NEUROSCIENCE

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling

(2012) Neil M. Fournier et al.   NEUROPHARMACOLOGY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders

(2012) Isaac S. Kohane et al.   PLoS One

Differential Contribution of Hypothalamic MAPK Activity to Anxiety-Like Behaviour in Virgin and Lactating Rats

(2012) Benjamin Jurek et al.   PLoS One

Fgf8-Related Secondary Organizers Exert Different Polarizing Planar Instructions along the Mouse Anterior Neural Tube

(2012) Ivan Crespo-Enriquez et al.   PLoS One

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

(2012) J H Zhu et al.   Cell Death & Disease

Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus

(2012) A Mogha et al.   Translational Psychiatry

Cholinergic influences on cortical development and adult neurogenesis

(2011) Elodie Bruel-Jungerman et al.   BEHAVIOURAL BRAIN RESEARCH

A novel target for Huntington's disease: ERK at the crossroads of signaling

(2011) László Bodai et al.   BIOESSAYS

FGF8 signaling is chemotactic for cardiac neural crest cells

(2011) Asako Sato et al.   DEVELOPMENTAL BIOLOGY

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality: Erk1 Deficiency Enhances the Impairment of Neurogenesis in Erk2-Deficient Mice

(2011) Y. Satoh et al.   JOURNAL OF NEUROSCIENCE

The Suppressive Effect of an Intra-Prefrontal Cortical Infusion of BDNF on Cocaine-Seeking Is Trk Receptor and Extracellular Signal-Regulated Protein Kinase Mitogen-Activated Protein Kinase Dependent

(2011) T. W. Whitfield et al.   JOURNAL OF NEUROSCIENCE

ERK2 Contributes to the Control of Social Behaviors in Mice

(2011) Y. Satoh et al.   JOURNAL OF NEUROSCIENCE

Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase

(2011) Janet L. Rossi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking

(2011) Matthias Nowak et al.   NATURE CELL BIOLOGY

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Effects of chronic social defeat stress on MAP kinase cascade

(2011) Wataru Iio et al.   NEUROSCIENCE LETTERS

Upregulation of Heme Oxygenase-1 by Acteoside Through ERK and PI3 K/Akt Pathway Confer Neuroprotection Against Beta-Amyloid-Induced Neurotoxicity

(2011) Hong-Quan Wang et al.   NEUROTOXICITY RESEARCH

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

MAPK signalling in cellular metabolism: stress or wellness?

(2010) Helmuth Gehart et al.   EMBO REPORTS

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning

(2010) K. T. Ota et al.   LEARNING & MEMORY

Roles of Ets-1 and p70S6 kinase in chondrogenic and gliogenic specification of mouse mesencephalic neural crest cells

(2010) Keisuke Sugiura et al.   MECHANISMS OF DEVELOPMENT

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood

(2010) Mazen A Kheirbek et al.   NEUROPSYCHOPHARMACOLOGY

Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity

(2009) Asuka Suzuki-Hirano et al.   DEVELOPMENTAL BIOLOGY

Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder

(2009) B. A. Fernandez et al.   JOURNAL OF MEDICAL GENETICS

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Activation of extracellular signal-regulated kinases in social behavior circuits during resident-intruder aggression tests

(2009) B.C. Trainor et al.   NEUROSCIENCE

Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis

(2008) Mamede De Carvalho et al.   Amyotrophic Lateral Sclerosis

Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus

(2008) Annegret Blume et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GABA-B1 Receptors are Coupled to the ERK1/2 MAP Kinase Pathway in the Absence of GABA-B2 Subunits

(2008) Maxime Richer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Resistance of cell lines to prion toxicity aided by phospho-ERK expression

(2008) Kay M. Uppington et al.   JOURNAL OF NEUROCHEMISTRY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Role of Erk1/2 activation in prion disease pathogenesis: Absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression

(2008) R LACASSE et al.   JOURNAL OF NEUROIMMUNOLOGY

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

(2008) I. S. Samuels et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo

(2008) G. E. Schafe et al.   LEARNING & MEMORY

Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons

(2008) B. Hausott et al.   NEUROSCIENCE

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

(2007) Emmanuel Roze et al.   FASEB JOURNAL

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

(2003) J. David Sweatt   JOURNAL OF NEUROCHEMISTRY