期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms21124309
关键词
positron emission tomography; Zr-89; monoclonal antibody; oncological imaging
资金
- National Research Foundation of Korea - Korea government [2017R1A2B2002692]
Zr-89 is an emerging radionuclide that plays an essential role in immuno-positron emission tomography (PET) imaging. The long half-life of(89)Zr (t(1/2)= 3.3 days) is favorable for evaluating the in vivo distribution of monoclonal antibodies. Thus, the use of(89)Zr is promising for monitoring antibody-based cancer therapies. Immuno-PET combines the sensitivity of PET with the specificity of antibodies. A number of studies have been conducted to investigate the feasibility of(89)Zr immuno-PET imaging for predicting the efficacy of radioimmunotherapy and antibody therapies, imaging target expression, detecting target-expressing tumors, and the monitoring of anti-cancer chemotherapies. In this review, we summarize the current status of PET imaging using(89)Zr in both preclinical and clinical studies by highlighting the use of immuno-PET for the targets of high clinical relevance. We also present(89)Zr-PET applications other than immuno-PET, such as nanoparticle imaging and cell tracking. Finally, we discuss the limitations and the ongoing research being performed to overcome the remaining hurdles.
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