Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Jennell White, Michael U. Callaghan, Xiufeng Gao, Ke Liu, Ahmar Zaidi, Michael Tarasev, Patrick C. Hines
Summary: This study evaluated the relationship between FA-WB-VCAM and SCD severity, finding a strong correlation. SCD patients with high frequency of self-reported VOCs exhibited a pro-adhesive phenotype at steady state, potentially impacting the frequency of VOC occurrences.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, Atsushi Yamauchi, Keisuke Migita
Summary: This study investigated the effect of bortezomib (BTZ) on vascular permeability and expression of cell-cell junction molecules in human pulmonary microvascular endothelial cells. The findings showed that clinically relevant concentrations of BTZ increased the permeability of endothelial cell monolayers and downregulated the expression of claudin-5, occludin, and VE-cadherin at both protein and mRNA levels. This suggests that BTZ-induced pulmonary toxicity may be mediated by increased vascular permeability caused by the downregulation of these cell-cell junction molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
R. M. Hashem, L. A. Rashed, R. M. Abdelkader, K. S. Hashem
Summary: The study demonstrated that MSCs therapy effectively replaced neointimal SMCs and reduced adhesion molecules, oxidative stress, and inflammatory markers in atherosclerosis, as evidenced by histopathological and biochemical analyses. Resveratrol was used as a benchmark to evaluate the efficacy of stem cell therapy, showing significant improvements in the experimental model of atherosclerosis.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Wen Deng, Caijiao Yi, Wei Pan, Jian Liu, Jinyan Qi, Juan Chen, Zengchao Zhou, Yiqin Duan, Xiangyan Ning, Jun Li, Changhua Ye, Zhongping Chen, Heping Xu
Summary: In patients with nAMD, levels of VCAM-1 were significantly elevated in those with macular fibrosis and correlated with retinal thickness. VCAM-1 was highly expressed at the site of fibrosis in a mouse model. Blocking VCAM-1 prevented macrophage infiltration and reduced subretinal fibrosis. VCAM-1 induced macrophage migration and influenced the expression of various genes involved in fibrosis.
Article
Immunology
Qiwei Qian, Nana Cui, Bingyuan Huang, Yudong Zhao, Qiaoyan Liu, Mingli Hu, Bo Li, Qixia Wang, Qi Miao, Zhengrui You, Xiong Ma, Ruqi Tang
Summary: The ALCAM-CD6 axis is upregulated in the liver of patients with autoimmune hepatitis (AIH), suggesting it as a potential target for alleviating AIH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sara Pastorino, Sara Baldassari, Giorgia Ailuno, Guendalina Zuccari, Giuliana Drava, Andrea Petretto, Vanessa Cossu, Cecilia Marini, Silvana Alfei, Tullio Florio, Gianmario Sambuceti, Gabriele Caviglioli
Summary: Atherosclerosis is a chronic progressive disease involving VCAM-1 overexpression. New PET radiopharmaceuticals MacroP and NAMP, based on VCAM-1 binding peptide, show high radiochemical purity and potential for early atheroma detection. NAMP also demonstrates higher radioactive uptake in vitro and may have future applications in theranostics.
Article
Biology
T. Koning, F. Cordova, G. Aguilar, J. Sarmiento, G. A. Mardones, M. Boric, M. Varas-Godoy, A. Lladser, W. N. Duran, P. Ehrenfeld, F. A. Sanchez
Summary: Nitric oxide (NO) is produced by different isoforms of nitric oxide synthases and activates two signaling pathways, one dependent on soluble guanylate cyclase and protein kinase G, and the other involving post-translational modification of proteins through S-nitrosylation. High levels of NO have been detected in blood of breast cancer patients, suggesting a positive correlation between NO biosynthesis, malignancy, and metastasis. The study shows that S-nitrosylation in the endothelium enhances VCAM-1 surface localization, promoting leukocyte and tumor cell adhesion and extravasation, potentially contributing to breast cancer metastasis.
BIOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Parimala Sonika Godavarthy, Christina B. Walter, Claudia Lengerke, Gerd Klein
Summary: Laminin receptors, specifically integrin alpha 7 beta 1 and BCAM/Lu, play crucial roles in both proliferation and homing of HSPC. While BCAM/Lu does not affect the adhesive interaction of HSPC with specific laminins, it does influence cell differentiation and migration processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Aline Floch, Christine Lomas-Francis, Sunitha Vege, Steven Brennan, Gayane Shakarian, Alexandre G. de Brevern, Connie M. Westhoff
Summary: A novel Lutheran antigen was identified and a updated BCAM 3D model was proposed. The study found that the c.212G > A change resulted in the loss of LUGA (LU24) antigen. This model and the discovery that nearly all residues associated with the expression of a Lutheran antigen are exposed will help evaluate the significance of new polymorphisms.
Article
Oncology
Yiming Yang, Andrew J. Sanders, Fiona Ruge, Xuefei Dong, Yuxin Cui, Qing Ping Dou, Shuqin Jia, Chunyi Hao, Jiafu Ji, Wen G. Jiang
Summary: The study showed that pancreatic cancer tissues have significantly higher levels of ALCAM transcripts compared to normal tissues, and that high levels of ALCAM expression are associated with poorer patient survival and microvessel embolism by cancer cells. Additionally, ALCAM plays a key role in mediating tumor-endothelial cell interactions and enhancing tumor embolism in pancreatic cancer, suggesting that targeting ALCAM could be a potential therapeutic strategy for treating human pancreatic cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Liangqingqing Yin, Jie Bai, Wei-Jia Yu, Ying Liu, Hui-Hua Li, Qiu-Yue Lin
Summary: The adhesion of monocytes to the vascular endothelium is an important factor in inflammatory response and contributes to hypertension and vascular remodeling. The role of VCAM-1 in Ang II-induced hypertension and vascular dysfunction is not well understood. Blocking VCAM-1 with a neutralizing antibody can alleviate these effects and represents a novel therapeutic approach for hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. J. Tschumperlin, Petra Hirsova, Samar H. H. Ibrahim
Summary: The study reveals that VCAM1 not only functions as a scaffold for leukocyte adhesion during liver injury, but also modulates LSEC capillarization and liver fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
L. Bordier, M. Buysschaert, B. Bauduceau, J. Doucet, C. Verny, V. Lassmann Vague, J. P. Le Floch
DIABETES & METABOLISM
(2015)
Article
Pharmacology & Pharmacy
Jean A. Doucet, Bernard Bauduceau, Jean-Pierre Le Floch, Christiane Verny
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2016)
Article
Hematology
Maria De Grandis, Marie Cambot, Marie-Paule Wautier, Bruno Cassinat, Christine Chomienne, Yves Colin, Jean-Luc Wautier, Caroline Le Van Kim, Wassim El Nemer
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: Inflammation, an old concept, is now recognized as important in infection and chronic diseases. Endothelial cells play a crucial role in regulating inflammatory processes. Advanced glycation end product receptor and inflammasome are key molecules in inflammation, and angiogenesis and thrombotic events are dysregulated during inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: The study of vascular permeability is important for understanding the mechanism that maintains the exchange between blood, tissues, and organs. Recent research has provided a better understanding of vascular cell functions and interactions between blood vessels. The identification of endothelial cell receptors and mediators and their role in homeostasis and disease has shed light on the maintenance of vascular permeability. Additionally, drugs and specific antibodies have been found to reduce the severity and mortality of diseases with enhanced vascular permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Marie-Paule Wautier, Pierre-Jean Guillausseau, Jean-Luc Wautier
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2017)
Meeting Abstract
Ophthalmology
Mayer Srour, Agnes Glacet, Jean-Francois Girmens, Laurent Kodjikian, Cecile DelCourt, Frank Fajnkuchen, Catherine P. Creuzot Garcher, Pascale Massin, Pierre-Jean Guillausseau, Anne Ponthieux, Laetitia Finzi, Angela Grelaud-Boussinot
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Meeting Abstract
Ophthalmology
Catherine P. Creuzot Garcher, Pascale Massin, Laurent Kodjikian, Jean-Francois Girmens, Cecile DelCourt, Frank Fajnkuchen, Agnes Glacet, Pierre-Jean Guillausseau, Audrey Derveloy, Laetitia Finzi, Patrick Blin
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Hematology
Jean-Luc Wautier, Marie-Paule Wautier
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2013)