期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 43, 期 10, 页码 1013-1016出版社
WILEY-BLACKWELL
DOI: 10.1111/1440-1681.12613
关键词
antibiotic resistant; intravenous administration; monkey; phage endolysin; staphylococci
SAL200 is a new phage endolysin-based candidate drug for the treatment of staphylococcal infections. An intravenous administration study was conducted in monkeys to obtain pharmacokinetic information on SAL200 and to assess the safety of a short SAL200 dosing period (<1week). Maximum serum drug concentrations and systemic SAL200 exposure were proportional to the dose and comparable in male and female monkeys. SAL200 was well tolerated, and no adverse events or laboratory abnormalities were detected after injection of a single dose of up to 80mg/kg per day, or injection of multiple doses of up to 40mg/kg per day.
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