期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 49, 期 6, 页码 1874-1882出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyaa091
关键词
Asthma; ECRHS; RHINESSA; farm upbringing; generation study; generational effects
资金
- Faculty of Health, Aarhus University, Denmark [240008]
- Wood Dust Foundation [444508795]
- Danish Lung Association
- Swedish Heart and Lung Foundation
- Swedish Association Against Asthma and Allergy
- Swedish Council for Working Life and Social Research
- Bror Hjerpstedt Foundation
- Vardal Foundation for Health Care and Allergic Research
- Norwegian Research Council [214123, 230827/F20, 228174, 135773/330]
- Norwegian Asthma and Allergy Association
- HelseVest Norway [911 631]
- Icelandic Research Council
- University of Iceland Research Fund
- Icelandic GP's Research Fund
- Estonian Science Foundation [4350]
- Estonian Research Council [PUT562]
- Melbourne University, National Health & Medical Research Council of Australia
- SEPAR Spain
- Sociedad Espanola de Neumologia y Cirugia Toracica Spain [Horizon2020 PHC1, 633212]
- Aarhus University, Denmark
Background: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. Methods: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945-1971, denoted G1), their 9991 parents (GO) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on GO and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale. Results: A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74-1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67-1.65) or paternal line (HR 1.02, 95% CI 0.62-1.68). Conclusions: This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma.
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