期刊
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
卷 35, 期 8, 页码 1397-1412出版社
SPRINGER
DOI: 10.1007/s00384-020-03658-z
关键词
Antibiotics; Colorectal cancer; Colon cancer; Rectal cancer; Meta-analysis
Purpose The association between antibiotics and colorectal cancer (CRC) risk has drawn increasing attention but remains controversial. This study was performed to clarify the association. Methods A systematic review and meta-analysis was performed on seven electronic databases. The pooled odds ratios (OR) with a 95% confidence interval (CI) were calculated to estimate the association using the fixed-effects model or the random-effects model. Results Ten studies that contained 4,853,289 participants were included in our study. We found that antibiotics use was associated with a higher risk of CRC (OR 1.09, 95%CI 1.02-1.17, I-2 = 92.8%). More than 60 days of antibiotics use and 5 prescriptions of antibiotics were significantly associated with a higher risk of CRC. Sub-analysis on different types of antibiotics found that anti-anaerobic antibiotics, penicillins, and quinolones use led to increased risk of CRC (OR 1.22, 95% CI 1.04-1.44, I-2 = 89.1%; OR 1.09, 95% CI 1.04-1.13, I-2 = 69.2%; OR 1.15, 95% CI 1.03-1.35, I-2 = 88.2%; respectively) and colon cancer (OR 1.28, 95% CI 1.04-1.58, I-2 = 98.5%; OR 1.09, 95% CI 1.05-1.12, I-2 = 0; OR 1.09, 95% CI 1.04-1.15, I-2 = 0; respectively). However, antibiotics use was not significantly associated with rectal cancer (OR 1.03, 95% CI 0.92-1.16, I-2 = 77.6%). Conclusion It needs attention that antibiotics use is associated with a higher risk of CRC, especially for colon cancer. Clinicians should be aware of the potential risk of CRC when prescribing anti-anaerobic antibiotics, penicillins, and quinolones in the future. Further studies are needed to assess any potential differences by tumor sites and class of antibiotics.
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