期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 156, 期 -, 页码 262-270出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.04.040
关键词
Nicotinamide; Chitosan; Nanoparticles; Topical; Clinical; Acne
Despite the popularity of chitosan as a biodegradable polymer used in a variety of applications, clinical trials involving chitosan or its nanoparticles are still scarce. Moreover, the use of nutraceuticals as a replacement to conventional chemical treatments has become currently popular, and if combined with nanotechnology, nutraceuticals can achieve a comparable or even better therapeutic outcome. In the current work chitosan nanopartides loading the nutraceutical nicotinamide were optimized, characterized, and clinically tested on patients suffering from acne vulgaris. The topical merits of chitosan nanopartides were proven, in which they exhibited strong skin adhesion ex vivo and high nicotinamide deposition in the different skin layers (stratum corneum, epidermis and dermis) amounting to a total of 68%. When clinically tested on patients, nicotinamide nanopartides displayed 73% reduction in the inflammatory acne lesions compared to untreated areas, hence proving that chitosan nanopartides can be a clinically sounding option for treatment of skin diseases. (C) 2020 Elsevier B.V. All rights reserved.
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