期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 155, 期 -, 页码 386-392出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.03.224
关键词
Sodium alginate; Feather keratin; Sustained drug release; Indomethacin
资金
- National Natural Science Foundation of China [51773024, 51373027]
- Innovation Team Foundation of Liaoning [LT2017017]
To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM. Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids. Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber. The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid. Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends. (C) 2020 Elsevier B.V. All rights reserved.
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