Article
Engineering, Multidisciplinary
Yan Li, Juan Wang, Yan Wang, Wenguo Cui
Summary: Hydrogel fibers, derived from the combination of hydrogel and electrospinning, have shown great potential in tissue regeneration and wound healing due to their structural properties and biological functions. Researchers have been particularly interested in the high specific surface area and mechanical advantages provided by these materials, making them promising for various biomedical applications.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Tao Li, Mingchao Sun, Shaohua Wu
Summary: Electrospun nanofiber materials, particularly those based on gelatin, have shown promise as advanced dressings for wound healing and skin regeneration. They possess high porosity, excellent barrier performance against pathogens, and a mimicry of extracellular matrix fibrils. Various crosslinking approaches and innovative electrospinning strategies have been used to enhance their mechanical properties. Additionally, bioactive components and therapeutic agents can be incorporated to impart multiple functions to these nanofiber dressings. This review provides a comprehensive overview of gelatin-based nanofiber dressings and their applications in wound healing and skin regeneration.
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Nur Izzah Md Fadilah, Shaima Maliha Riha, Zawani Mazlan, Adzim Poh Yuen Wen, Looi Qi Hao, Blessy Joseph, Manira Maarof, Sabu Thomas, Antonella Motta, Mh Busra Fauzi
Summary: Skin tissue engineering holds great potential for successful wound and tissue loss treatments that current methods cannot achieve. The use of multifunctional bioscaffolds, made from natural and synthetic biomaterials, offers an environment that enhances biological performance and accelerates skin tissue regeneration. These bioscaffolds provide a biomimetic framework that guides cell regeneration and can be customized to distribute bioactive chemicals or cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Zhengbo Wen, Yuxin Chen, Peilin Liao, Fengyu Wang, Weiping Zeng, Shoupei Liu, Haibing Wu, Ning Wang, Lorenzo Moroni, Minmin Zhang, Yuyou Duan, Honglin Chen
Summary: In this study, an in situ cell electrospinning system was developed as an attractive approach for stem cell delivery, which could promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergistic therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Yue Li, QingQing Leng, XianLun Pang, Huan Shi, YanLin Liu, SuSu Xiao, Ling Zhao, Ping Zhou, ShaoZhi Fu
Summary: A novel nano-drug delivery system, EGF@CCN, was developed for treating skin defects, showing significant advantages in promoting wound healing. The prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.
REGENERATIVE BIOMATERIALS
(2021)
Article
Engineering, Biomedical
Jingchen Xu, Yao Lin, Yue Wang, Hongyu Gao, Yuanhong Li, Chaoliang Zhang, Qianming Chen, Song Chen, Qiang Peng
Summary: Developing multifunctional wound dressings accommodating the complex microenvironment of diabetic wounds is of great significance. In this study, a multifunctional hydrogel loaded with regeneration silicon (Regesi-CS) showed great antibacterial activity, improved cell function, and promoted wound healing in diabetic wound models.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Alex Bryan, Ethan Wales, Samarth Vedante, Andreu Blanquer, Dipesh Neupane, Sanjay Mishra, Lucie Bacakova, Tomoko Fujiwara, Jessica Amber Jennings, Joel D. Bumgardner
Summary: This study successfully incorporated elastin and magnesium-phosphate particles into electrospun chitosan membranes, improving their properties for burn wound applications. Evaluation of fiber size, structure, hydrophilicity, elastin and MgP incorporation, release profiles, mechanical properties, degradation, and cytocompatibility showed that the addition of elastin and MgP enhanced the performance of the membranes.
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Review
Emergency Medicine
Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin
Summary: This article summarizes the potential of cell electrospinning (C-ES) technology, based on the technique of electrospinning (ES), in promoting wound healing. It discusses the advantages of C-ES, the differences between C-ES and traditional ES, suitable parameters for maintaining cytoactivity, material selection and design, and the application of C-ES in biomaterials and cells. It also explores the limitations and improved methods of C-ES.
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Article
Chemistry, Applied
Yao Lin, Jingchen Xu, Yuanhao Dong, Yue Wang, Chenhao Yu, Yuanhong Li, Chaoliang Zhang, Qianming Chen, Song Chen, Qiang Peng
Summary: We developed a drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hydrogel with multiple functions for synergistic healing of MRSA-infected diabetic wounds. The CS/HA hydrogel exhibited broad-spectrum antibacterial activity, promoted fibroblast proliferation and migration, scavenged reactive oxygen species (ROS), and protected cells under oxidative stress. In MRSA-infected diabetic mouse wounds, CS/HA hydrogel significantly promoted wound healing by eliminating MRSA infection and enhancing epidermal regeneration, collagen deposition, and angiogenesis. With its drug-free feature, ready availability, excellent biocompatibility, and remarkable wound healing efficacy, CS/HA hydrogel shows great potential for managing chronic diabetic wounds in clinical use.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Ruinan Hao, Zhuoyi Cui, Xindan Zhang, Ming Tian, Liqun Zhang, Feng Rao, Jiajia Xue
Summary: Skin wound healing is a dynamic and complex process, and effectively treating wounds and regenerating damaged skin is a clinical challenge. Hydrogels, through rational design and preparation, have the potential to play a significant role in skin wound healing. This mini review introduces the design and construction of hydrogels, summarizes the recent research progress on functional bioactive hydrogel dressings for skin wound healing, and highlights the design strategies of responsive hydrogels to physical stimuli. The review also provides perspectives on future directions and challenges of functional hydrogels for skin wound healing.
FRONTIERS IN CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Marek Konop, Mateusz Rybka, Adrian Drapala
Summary: Researchers are exploring the use of keratin biomaterials as wound dressings to aid in skin regeneration, due to their tissue biocompatibility, biodegradability, mechanical durability, and natural abundance properties.
Article
Materials Science, Biomaterials
Wanxin Guo, Binan Zhao, Muhammad Shafiq, Xiao Yu, Yihong Shen, Jie Cui, Yujie Chen, Pengfei Cai, Zhengchao Yuan, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Binbin Sun, Jianfeng Pan, Xiumei Mo
Summary: The objective of this research was to screen for the effect of different types of bio-elastomers as hemostatic dressings. A PU-TA/Gel sponge was prepared, which showed promising potential in terms of porosity, water absorption ratio, cytocompatibility, hemolysis, clotting time, and wound healing. The sponge rapidly induced stable blood clots and good skin regeneration.
REGENERATIVE BIOMATERIALS
(2023)
Review
Engineering, Environmental
Robin Augustine, Mert Gezek, Nazli Seray Bostanci, Angelina Nguyen, Gulden Camci-Unal
Summary: The lack of oxygen supply in engineered constructs poses a major challenge in tissue engineering and regenerative medicine. Providing and maintaining adequate oxygen levels in large tissue-engineered constructs as well as during transportation and storage is crucial. Recent approaches involve incorporating oxygen-generating materials such as peroxides and fluorinated substances into scaffolds. This review paper highlights the importance of oxygen-generating materials in various tissue engineering approaches and discusses challenges, solutions, and future strategies in designing clinically relevant multifunctional biomaterials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Robin Augustine, Sumama Nuthana Kalva, Yogesh B. Dalvi, Ruby Varghese, Maneesh Chandran, Anwarul Hasan
Summary: The development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. Air-jet spinning is an upcoming alternative approach for generating loosely arranged nanofibrous scaffolds within short time. In this study, polycaprolactone (PCL) tissue engineering scaffolds loaded with diamond nanosheets (DNS) were fabricated by air-jet spinning, and the inclusion of DNS improved the mechanical strength of the scaffolds. In vitro and in vivo studies demonstrated the high biocompatibility of PCL-DNS scaffolds, making them suitable for tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Materials Science, Biomaterials
Majid Sharifi, Mohammad Kamalabadi Farahani, Majid Salehi, Amir Atashi, Morteza Alizadeh, Rasoul Kheradmandi, Sahar Molzemi
Summary: Despite being considered a medical challenge, there is hope for the regeneration of peripheral nerves through the use of metal nanoparticles. These nanoparticles can modify scaffolds and conduits, enhance neurotrophic factor secretion, improve ion flow, and regulate electrical signals to aid in the regeneration of damaged nerves. Determining the fate of neural progenitor cells using metal nanoparticles is a major achievement in peripheral nerve regeneration. This article aims to provide an overview of the effectiveness of metal nanoparticles in promoting peripheral nerve regeneration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Automation & Control Systems
Farhan Fuad Abir, Muhammad E. H. Chowdhury, Malisha Islam Tapotee, Adam Mushtak, Amith Khandakar, Sakib Mahmud, Md Anwarul Hasan
Summary: Researchers propose a deep learning framework called PCovNet+ for detecting COVID-19 infection through monitoring the user's Resting Heart Rate (RHR). The framework shows promising results in virus diagnosis and continuous health monitoring.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Review
Biotechnology & Applied Microbiology
Suliman Khan, William C. Cho, Afrooz Sepahvand, Sara Haji Hosseinali, Arif Hussain, Mohammad Mahdi Nejadi Babadaei, Majid Sharifi, Mojtaba Falahati, Laila Abdulmohsen Jaragh-Alhadad, Timo L. M. ten Hagen, Xin Li
Summary: Developing ultrasensitive biosensors is crucial for cancer detection and treatment monitoring. Metal-organic frameworks (MOFs) have received significant attention as potential nanoscale porous crystalline structures in sensing platforms. Core-shell MOF nanoparticles (NPs) exhibit diverse biological functionalities, significant electrochemical properties, and potential bio-affinity to aptamers. As a result, core-shell MOF-based aptasensors have been developed as highly sensitive platforms for detecting cancer biomarkers with an extremely low limit of detection (LOD).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Umar Aslam Khan, Goran M. Stojanovic, Rozita Hassan, T. Joseph Sahaya Anand, Maryam Al-Ejji, Anwarul Hasan
Summary: In this study, composite hydrogels made from gelatin and graphene oxide-functionalized bacterial cellulose were fabricated and crosslinked with tetraethyl orthosilicate. The hydrogels exhibited good surface morphology and wetting behavior. They showed excellent swelling, biodegradation, and water retention properties in response to biofluid. The hydrogels also exhibited antimicrobial activities and promoted cell viability and proliferation. Therefore, these hydrogels have potential as wound dressing materials for wound healing applications.
Article
Oncology
Majid Sharifi, Rasoul Kheradmandi, Morteza Alizadeh
Summary: For the treatment of triple-negative breast cancer (TNBC), a potential approach is combining gemcitabine with photodynamic therapy (PDT) on a nanozyme platform. The nanozyme, platinum-cobalt@gemcitabine-hyaluronic acid-polyethylene glycol (PtCo@Gem-HA-PEG), showed high toxicity on TNBC cells and tumors by enhancing catalase-/peroxidase-like activities. PtCo@Gem-HAPEG inhibited tumor development and increased drug accumulation in the tumor through synergistic activity with PDT. However, long-term application of PtCo@Gem-HA-PEG may lead to major organ damage, making their use challenging.
CANCER NANOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Suliman Khan, Mojtaba Falahati, William C. Cho, Yasaman Vahdani, Rabeea Siddique, Majid Sharifi, Laila Abdulmohsen Jaragh-Alhadad, Setareh Haghighat, Xiaoju Zhang, Timo L. M. ten Hagen, Qian Bai
Summary: Metal-organic framework (MOF) nanostructures are ideal candidates for developing drug delivery systems and theranostic platforms in cancer treatment due to their unique characteristics. Developing core-shell MOF nanostructures with good colloidal stability is an effective method for generating efficient drug delivery and multimodal imaging-guided therapeutic systems. In this article, we overviewed the synthesis of core-shell inorganic NP@MOF nanostructures and their application in drug delivery and imaging-guided tumor treatment. We also discussed the factors affecting prolonged drug delivery and cancer therapy, cellular uptake, biocompatibility, biodegradability, and enhanced permeation and retention (EPR) effect of core-shell MOFs.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Medicine, Research & Experimental
Asad Ullah, Abdulla Al Mamun, Midhat Batool Zaidi, Talat Roome, Anwarul Hasan
Summary: Impaired wound healing is a common problem in diabetes patients, leading to severe complications. Chronic hypoxia is a major factor in delayed wound healing. This study developed a hydrogel containing oxygen-releasing nanoparticles to provide sustained delivery of oxygen. In vitro and in vivo experiments showed improved biocompatibility, cell proliferation, and migration, leading to accelerated wound closure in diabetic rat model.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Rida Badar, Saima Zulfiqar, Alap Ali Zahid, Nadia Mehmood, Rabia Zeeshan, Ayesha Nawaz, Najiya Al-Arifa, Anwarul Hasan, Sher Zaman Safi, Ihtesham Ur Rehman, Muhammad Yar
Summary: This study focused on the modification of advanced wound care products, specifically materials stimulating angiogenesis, by loading thyroxine into alginate dressings. The results showed that thyroxine loaded alginate dressings have high potential for promoting angiogenesis and fast wound healing.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiadi Li, Yuxin Zhou, Shuixin Yan, Weizhu Wu, Majid Sharifi
Summary: This paper presents the development of an intelligent therapeutic nano-based system derived from metal-organic framework (MOF) core-shell hybrids. The system demonstrates facilitated drug penetration inside cancer cells and tumor microenvironment-triggered drug release.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Ali Coyle, Arghya Paul
Summary: Biobased nanoparticles are promising tools for biomedical research, but their commercial application has not been fully realized. In this perspective, advanced designs of biobased nanoparticles, such as cell membrane nanoparticles, exosomes, and synthetic lipid-derived nanoparticles, are discussed along with their benefits and potential challenges. The future use of artificial intelligence and machine learning in preparing these particles is also critically assessed. This field of research has the potential to greatly impact the rational design of drug transporters and improve therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Umar Aslam Khan, Goran M. Stojanovic, Roselinda Ab Rehman, Ali-Reza Moradi, Muhammad Rizwan, Nureddin Ashammakhi, Anwarul Hasan
Summary: Biopolymer-based bioactive hydrogels exhibit excellent properties for wound healing applications. The study explored the synthesis and characterization of bioactive hydrogels made from bacterial cellulose and gelatin. The hydrogels demonstrated desirable swelling behavior, controlled drug release kinetics, and showed good cell compatibility and antibacterial activity.
Article
Engineering, Biomedical
Khaled Youssef, Asad Ullah, Pouya Rezai, Anwarul Hasan, Alidad Amirfazli
Summary: Chronic wounds are a significant healthcare issue worldwide, often leading to morbidity, limb loss, and even death. Microbial infection in wounds hampers the healing process. Smart bandages with integrated sensors can detect wound infection based on various parameters, such as pH, temperature, and oxygen level, reducing the need for frequent replacement of dressings and improving the quality of patient care.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Biomaterials
Robin Augustine, Gulden Camci-Unal
Summary: Maintaining adequate oxygen levels within implanted scaffolds is a major challenge in bone tissue engineering. We developed an oxygen-generating scaffold using electrospinning technology and characterized its physical, chemical, and biological properties. The scaffold provided controlled oxygen release, supported cell proliferation, and facilitated bone defect contraction in vitro. Our approach shows promise for developing tissue-engineered products targeting bone defects.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
