期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 50, 期 9, 页码 697-705出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2020.05.008
关键词
MicroRNA; Extracellular vesicles; Host-parasite interactions; Trichinella spiralis
类别
资金
- UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M0111788/1]
- BBSRC [BB/S001085/1, BB/L023091/1]
- UK Medical Research Council
- BBSRC [BB/L023091/1, 1655059, BB/S001085/1] Funding Source: UKRI
Many organisms, including parasitic nematodes, secrete small RNAs into the extracellular environment, largely encapsulated within small vesicles. Parasite-secreted material often contains microRNAs (miRNAs), raising the possibility that they might regulate host genes in target cells. Here we characterise secreted RNAs from the parasitic nematode Trichinella spiralis at two different life stages. We show that adult T. spiralis, which inhabit intestinal mucosa, secrete miRNAs within vesicles. Unexpectedly, T. spiralis muscle stage larvae, which live intracellularly within skeletal muscle cells, secrete miRNAs that appear not to be encapsulated. Notably, secreted miRNAs include a homologue of mammalian miRNA-31, which has an important role in muscle development. Our work therefore suggests that RNAs may be secreted without encapsulation in vesicles, with implications for the biology of T. spiralis infection. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of Australian Society for Parasitology.
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