期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 185, 期 1, 页码 86-97出版社
WILEY-BLACKWELL
DOI: 10.1111/cei.12790
关键词
17-oestradiol; human pregnancy; MDSC; STAT-3
类别
资金
- National Key Basic Research Program of China [2012CB524900]
- Guangdong Innovative Research Team Program [2009010058]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS)
- Programme for the 12th Five-year Plan [2012ZX10001003]
- National Natural Science Foundation of China [91542112, 81571520, 31270921, 301500740]
- Natural Science Foundation of Guangdong [S2011020006072]
- Fundamental Research Funds for the Central Universities
- Provincial Talents Cultivated by Thousand-Hundred-Ten' programme of Guangdong Province
- 111 Project [B12003]
During a successful pregnancy, the maternal immune system plays a critical role in maintaining immunotolerance towards semi-allogeneic fetal antigens. Recent studies have indicated that myeloid-derived suppressor cells (MDSCs) are active players in establishing fetal-maternal tolerance; however, the underlying mechanism remains poorly understood. In this study, we observed a significant expansion of monocytic MDSCs (M-MDSCs) in the peripheral blood of pregnant women, which suppressed T cell responses in a reactive oxygen species-dependent manner and required cell-cell contact. The number of M-MDSCs correlated positively with serum oestrogen and progesterone levels. Administration of 17-oestradiol, but not progesterone, enhanced both the expansion and suppressive activity of M-MDSCs through signal transducer and activator of transcription (STAT)-3. Pretreatment with STAT-3 inhibitor JSI-124 almost completely abrogated the effects of 17-oestradiol on MDSCs. Collectively, these results demonstrate that 17-oestradiol-induced STAT-3 signalling plays an important role in both the expansion and activation of MDSCs during human pregnancy, which may benefit the development of novel therapeutic strategies for prevention of immune-related miscarriage.
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