期刊
INORGANICA CHIMICA ACTA
卷 507, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2020.119588
关键词
N-heterocyclic carbene; Iridium complexes; Theophylline complex; Cancer; Cytotoxic activity; Thiolate complexes; Xanthines
资金
- Programa de Becas PosdoctoralesDGAPA-UNAM [CJIC/CTIC/4751/2018]
- PAPIIT-DGAPA-UNAM [PAPIIT IN210520]
- CONACYT [A1-S-33933]
A series of theophylline-based Ir(I) N-heterocyclic carbene complexes including fluorinated-thiolate ligands have been prepared and fully characterized. The molecular structures of the complexes [(NHC)Ir(SC6F5)(COD)] (3a) and [(NHC)Ir(SC6F4H-4)(COD)] (3b) were unambiguously determined by single crystal X-ray diffraction analysis. Both compounds were isostructural, having the theophylline-imidazolylidene ligand coordinated to the metal center and completing the coordination sphere with a 1,5-COD and thiophenolate ligands. Interestingly, both complexes exhibit both inter- and intra-molecular pi-stacking interactions between the fluorinated ring of the thiolate and the theophylline-based NHC ligand. Furthermore, for the series of Ir(I) NHC complexes preliminary in vitro anticancer activity experiments were performed on six human cancer cell-lines, i.e. glia cells of nervous central system (U-251), prostate (PC-3), leukemia (K-562), colon (HCT-15), breast (MCF-7) and lung (SKLU-1). Being complex (3) the one showing the best performance (compared to cisplatin) against PC-3 and SKLU-1 with IC50 values of 7.8 +/- 0.4 mu M and 10.7 +/- 0.7 mu M, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据