Raised interferon-β, type 3 interferon and interferon-stimulated genes - evidence of innate immune activation in neutrophilic asthma

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

(2016) Jodie L. Simpson et al.   CHEST

Association between Proximity to Major Roads and Sputum Cell Counts

(2016) Julie Wallace et al.   Canadian Respiratory Journal

Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells

(2015) M. Contoli et al.   ALLERGY

Airway dysbiosis:Haemophilus influenzaeandTropherymain poorly controlled asthma

(2015) Jodie L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

(2015) Vera Gielen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression

(2015) Elizabeth A. Schwantes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial

(2014) Ratko Djukanović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations

(2014) E. A. Schwantes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

(2014) F. N. Schleich et al.   EUROPEAN RESPIRATORY JOURNAL

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR)

(2014) F. Schleich et al.   RESPIRATORY MEDICINE

Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expression

(2013) Sameer K. Mathur et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Microbes and mucosal immune responses in asthma

(2013) Trevor T Hansel et al.   LANCET

Sputum IgE and Cytokines in Asthma: Relationship with Sputum Cellular Profile

(2013) Maïté Manise et al.   PLoS One

Rhinovirus-induced interferon production is not deficient in well controlled asthma

(2013) Annemarie Sykes et al.   THORAX

Effects of high altitude and cold air exposure on airway inflammation in patients with asthma

(2013) Sven F Seys et al.   THORAX

Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

(2013) Florence N Schleich et al.   BMC Pulmonary Medicine

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients

(2012) Annemarie Sykes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

(2012) M R Edwards et al.   Mucosal Immunology

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

(2012) Nicole Bedke et al.   PLoS One

Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD

(2012) Davinder S Garcha et al.   THORAX

Induced Sputum in Asthma: From Bench to Bedside

(2011) P. Bakakos et al.   CURRENT MEDICINAL CHEMISTRY

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

(2011) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytokine production from sputum cells and blood leukocytes in asthmatics according to disease severity

(2010) M. Manise et al.   ALLERGY

Azithromycin induces anti-viral responses in bronchial epithelial cells

(2010) V. Gielen et al.   EUROPEAN RESPIRATORY JOURNAL

Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia

(2010) Lisa G. Wood et al.   FREE RADICAL RESEARCH

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Transforming Growth Factor-β Enhances Rhinovirus Infection by Diminishing Early Innate Responses

(2009) Belinda J. Thomas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross-sectional study in daily practice

(2009) V. Quaedvlieg et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Differential gene expression and cytokine production from neutrophils in asthma phenotypes

(2009) K. J. Baines et al.   EUROPEAN RESPIRATORY JOURNAL

Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma

(2009) Y A Bochkov et al.   Mucosal Immunology

Type III IFN-λ mRNA expression in sputum of adult and school-aged asthmatics

(2008) Dominique M. A. Bullens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET