Article
Acoustics
Weng Heng Liew, Qingqing Ke, Chin Yaw Tan, Shuting Chen, Kui Yao
Summary: The performance of ultrasonic transducer is crucial for functional imaging on biological samples. Implementing a piezoelectric multilayer structure instead of the conventional single layer can significantly enhance receiving sensitivity and improve imaging resolution.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Acoustics
Qingqing Ke, Weng Heng Liew, Lei Zhang, Chin Yaw Tan, Chang-Yun Jiang, Chee Kiang Ivan Tan, Kui Yao
Summary: This article presents the design and fabrication of a focused 5-MHz 128-element linear-array ultrasonic transducer with concave structure, using piezoelectric ceramic, showcasing higher bandwidth and lateral resolution.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Acoustics
Danyang Ren, Chiye Li, Junhui Shi, Ruimin Chen
Summary: Photoacoustic imaging is a new hybrid biomedical imaging modality that combines the benefits of optical and ultrasound imaging. The advancement in high-frequency ultrasound transducer technology has greatly influenced the applications of photoacoustic imaging.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Engineering, Electrical & Electronic
Ya-Han Liu, Li-Xiang Chen, Chih-Ying Li, Fu-Sung Lin, Hsin-Yi Su, Chi-Ting Tsai, Li-Wen Wang, Yeong-Her Wang, Chih-Hsien Huang
Summary: A wearable transparent ultrasonic transducer was developed and applied in a PAI system with excellent performance, demonstrating potential for large-field PAI application in wearable health devices. The acoustic sensor, with a sandwich structure, exhibited a 6.7 MHz center frequency, an 86.3% -3 dB fractional bandwidth, and a 20 x 20 x 36 mm(3) volumetric imaging field.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Zhenfeng Gong, Guojie Wu, Ke Chen, Min Guo, Junsheng Ma, Haie Li, Fengxiang Ma, Liang Mei, Wei Peng, Qingxu Yu
Summary: This paper presents a fiber-tip all-optical photoacoustic transducer with a special structure, small volume, and high sensitivity. The transducer is suitable for remote, long-distance, and limited-space trace gas detection.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Acoustics
Zhihua Xie, Jiamei Liu, Yaguang Ren, Jiqing Huang, Riqiang Lin, Xiatian Wang, Qingyuan Tan, Shengmiao Lv, Liang Song, Chengbo Liu, Teng Ma, Xiaojing Gong
Summary: Photoacoustic/ultrasound endoscopic imaging is an effective method for accurate detection of intestinal disease by providing both functional and structural information. A compact circular endoscopic probe is developed by using a group of fiber, lens, and homemade axicon to generate a concentrated ring-shaped laser beam for 360 degrees excitation. The probe has a wide imaging distance range and high optical excitation efficiency.
Article
Acoustics
Amir Gholampour, Jan-Willem Muller, Camilo Cano, Marc R. H. M. van Sambeek, Richard Lopata, Hans-Martin Schwab, Min Wu
Summary: Photoacoustic imaging (PAI) is a promising technique for evaluating different constituents in tissue by using low-amplitude, isotropic, and broadband propagating waves. In this study, a multiperspective PAI (MP-PAI) approach using multiple CMUTs on a flexible array with shared channels was proposed to improve the field of view, resolution, and contrast, and was validated through several experiments.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Engineering, Biomedical
Shang Gao, Yiwei Jiang, Mucheng Li, Yang Wang, Yao Shen, Matthew C. Flegal, Benjamin C. Nephew, Gregory S. Fischer, Yuxiang Liu, Loris Fichera, Haichong K. Zhang
Summary: We developed a flexible miniaturized photoacoustic imaging probe by modifying and incorporating custom-fabricated fibers into an ultrasound laparoscopic probe. The probe allows intraoperative detection of blood vessels and nerve bundles not directly visible, thus preserving these vital structures.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Automation & Control Systems
Chang Peng, Mengyue Chen, Hongchao Wang, Jian Shen, Xiaoning Jiang
Summary: This research first designed a multi-layer under-display ultrasonic fingerprint sensor structure, which was theoretically analyzed and fabricated with high resolution and sensitivity to meet the requirements of under-display ultrasonic fingerprint imaging applications, as tested with a custom-made fingerprint-mimicking phantom. The results suggest that the 20 MHz broadband PZT-based multilayer structure holds great potential for under-display ultrasonic fingerprint sensor applications.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Cheng Fang, Zijie Zhao, Jie Fang, Jun Zou
Summary: This article presents a new optically transparent transducer for photoacoustic microscopy (PAM) using poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) film. The transducer is fabricated using a simplified process based on precutting and direct lamination. Experimental results show that the transducer has good optical transmittance and acoustic performance, making it useful for different imaging applications in PAM systems.
IEEE SENSORS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Jeongwoo Park, Byullee Park, Tae Yeong Kim, Sungjin Jung, Woo June Choi, Joongho Ahn, Dong Hee Yoon, Jeongho Kim, Seungwan Jeon, Donghyun Lee, Uijung Yong, Jinah Jang, Won Jong Kim, Hong Kyun Kim, Unyong Jeong, Hyung Ham Kim, Chulhong Kim
Summary: The study demonstrates a quadruple fusion imaging system that seamlessly integrates ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging using a spherically focused transparent ultrasound transducer. The system was used to monitor responses to chemical and suture injuries in rats' eyes, as well as for multimodal imaging of tumors in vivo. It is believed that this integrated multimodal system can have broad applications in ophthalmology, oncology, and beyond.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Acoustics
Zuhayr Rymansaib, Polat Kurt, Yan Zhang, James I. Roscow, Christopher R. Bowen, Alan J. Hunter
Summary: This article discusses the application of the freeze-casting technique in the fabrication of porous piezoelectric ceramics for underwater ultrasonic transducers. The results show that the porous freeze-cast transducers have comparable acoustic performance to their dense counterparts.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Biotechnology & Applied Microbiology
Weiran Pang, Yongjun Wang, Lili Guo, Bo Wang, Puxiang Lai, Jiaying Xiao
Summary: This paper proposes an acoustic-resolution PA/USE with a line-focused transducer to achieve automatic focusing. Numerical simulations and phantom experiments verify the feasibility of this method. The proposed method improves the lateral resolution in the defocused region, solves the problem of target signal difference in the far-focus region, and enhances the image SNR and contrast.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Optics
Bai-Ou Guan, Long Jin, Jun Ma, Yizhi Liang, Xue Bai
Summary: Photoacoustic imaging (PAI) technology has been developed to achieve multiscale imaging of biological samples using a flexible fiber-laser ultrasound sensor (FUS) based on optical fibers. The FUS allows for tuning of spatial ultrasound responses by bending the fiber laser, enabling wide-view optical-resolution photoacoustic microscopy and photoacoustic computed tomography at different depths. Compared to traditional rigid piezoelectric transducers, the flexible FUS provides the flexibility to design various multiscale PAI modalities.
OPTO-ELECTRONIC ADVANCES
(2021)
Article
Chemistry, Analytical
Tianning Liu, Ajay Dangi, Jeong Nyeon Kim, Sri-Rajasekhar Kothapalli, Kyusun Choi, Susan Trolier-McKinstry, Thomas Jackson
Summary: This study presents flexible thin-film lead zirconate titanate (PZT)-based ultrasonic transducers on polyimide substrates that exhibit strong performance for underwater applications.
Article
Chemistry, Analytical
Sumit Agrawal, Mithun Kuniyil Ajith Singh, Kerrick Johnstonbaugh, David C. Han, Colette R. Pameijer, Sri-Rajasekhar Kothapalli
Summary: Vascular diseases are on the rise due to aging population and lifestyle factors, creating a need for point-of-care diagnosis. LED-based photoacoustic imaging shows promise for portable and cost-effective vascular imaging, with higher signal-to-noise ratios at shallower depths compared to high-energy laser sources. Led-PAI systems have potential for mobile health care in diagnosing vascular diseases in resource-limited settings.
Article
Chemistry, Analytical
Tianning Liu, Ajay Dangi, Jeong Nyeon Kim, Sri-Rajasekhar Kothapalli, Kyusun Choi, Susan Trolier-McKinstry, Thomas Jackson
Summary: This study presents flexible thin-film lead zirconate titanate (PZT)-based ultrasonic transducers on polyimide substrates that exhibit strong performance for underwater applications.
Article
Computer Science, Interdisciplinary Applications
Amirsaeed Yazdani, Sumit Agrawal, Kerrick Johnstonbaugh, Sri-Rajasekhar Kothapalli, Vishal Monga
Summary: A novel deep learning method is developed to address noise robustness in photoacoustic radio-frequency (RF) data, enabling accurate localization of deep targets and improving model performance. The proposed architecture outperforms the state of the art on both simulated and experimental datasets, demonstrating its effectiveness in clinical applications.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Acoustics
Sumit Agrawal, Thaarakh Suresh, Ankit Garikipati, Ajay Dangi, Sri-Rajasekhar Kothapalli
Summary: Combined ultrasound and photoacoustic (USPA) imaging shows promise in pre-clinical and clinical applications, but current limitations include optical attenuation and heterogeneities. Novel instrumentation, image reconstruction, and artificial intelligence methods are being explored to improve image quality and overcome these challenges.
Article
Chemistry, Analytical
Christopher Cheng, Travis Peters, Ajay Dangi, Sumit Agrawal, Haoyang Chen, Sri-Rajasekhar Kothapalli, Susan Trolier-McKinstry
Summary: This study investigates the improvement of receive sensitivity in PZT piezoelectric micromachined ultrasound transducers (PMUTs) by applying a DC bias. The results show that the PMUT receive sensitivity and photoacoustic signal can be significantly improved by applying a DC bias.
Article
Acoustics
Mohamed S. Osman, Haoyang Chen, Kevin Creamer, Josiah Minotto, Jinyun Liu, Shubham Mirg, Johnny Christian, Xianglong Bai, Sumit Agrawal, Sri-Rajasekhar Kothapalli, Mohamed Sameh Osman
Summary: This study investigates the acoustic matching layer in transparent ultrasound transducer (TUT) technology. By using translucent glass beads in transparent epoxy as the matching layer, the pulse-echo sensitivity and bandwidth of TUTs can be significantly improved, and the optical density uniformity of the photoacoustic signal can be enhanced.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Chemistry, Analytical
Janggun Jo, Eamon Salfi, Jeff Folz, Aaron M. Udager, Evan Keller, Raoul Kopelman, Sri-Rajasekhar Kothapalli, Guan Xu, Xueding Wang
Summary: This study utilized methylene blue polyacrylamide nanoparticles (MB PAA NPs) as a contrast agent to conduct photoacoustic spectral analysis (PASA) in a transgenic mouse model of prostate cancer (PCa), and found significant differences between normal and cancer, as well as low-score and high-score cancer. The results demonstrated that PA imaging and PASA, powered by MB PAA NPs, can effectively detect PCa tumors and evaluate cancer aggressiveness.
Article
Engineering, Biomedical
Haoyang Chen, Sumit Agrawal, Mohamed Osman, Josiah Minotto, Shubham Mirg, Jinyun Liu, Ajay Dangi, Quyen Tran, Thomas Jackson, Sri-Rajasekhar Kothapalli
Summary: This article presents a novel method of multimodal imaging using a transparent ultrasound transducer, which enables high-resolution mapping of structural, functional, and molecular biomarkers inside living subjects. It has potential applications in diagnosing cancer, neurological, and vascular diseases.
Article
Biochemical Research Methods
Haoyang Chen, Ninghao Zhu, Mohamed Osman, Ryan Biskowitz, Jinyun Liu, Shubham Khandare, Peter Butler, Pak Kin Wong, Sri-Rajasekhar Kothapalli
Summary: An on-chip platform for low-intensity pulsed ultrasound (LIPUS) stimulation of cells has been developed, enabling direct culture on a transparent ultrasound transducer surface. The platform allows for optimal stimulation parameters for both non-thermal and thermal effects, as confirmed by fluorescence analysis and temperature measurements. The method shows potential for safe and effective mechanical stimulation of cells.
Article
Engineering, Electrical & Electronic
Sumit Agrawal, Prameth Gaddale, Sri Phani Krishna Karri, Sri-Rajasekhar Kothapalli
Summary: A modified independent component analysis (ICA) model was proposed to construct adaptive components for tissue chromophores, improving the accuracy of noninvasive photoacoustic imaging techniques. The unsupervised nature of the approach outperformed standard methods in simulated and experimental data, demonstrating its potential for biomedical applications.
IEEE SENSORS LETTERS
(2021)
