Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Michael A. Puskarich, Nicholas E. Ingraham, Lisa H. Merck, Brian E. Driver, David A. Wacker, Lauren Page Black, Alan E. Jones, Courtney Fletcher, Andrew M. South, Thomas A. Murray, Christopher Lewandowski, Joseph Farhat, Justin L. Benoit, Michelle H. Biros, Kartik Cherabuddi, Jeffrey G. Chipman, Timothy W. Schacker, Faheem W. Guirgis, Helen T. Voelker, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: This study found that oral administration of losartan did not improve the PaO2:FiO(2) ratio at 7 days in hospitalized patients with COVID-19 and acute lung injury. The use of losartan also did not improve secondary clinical outcomes and resulted in fewer vasopressor-free days compared to placebo.
Review
Cardiac & Cardiovascular Systems
Xiao-Ce Dai, Zhuo-Yu An, Zi-Yang Wang, Zi-Zhen Wang, Yi-Ren Wang
Summary: The use of ACEIs/ARBs does not appear to have a significant impact on mortality, disease severity, or duration of hospitalization in COVID-19 patients. Based on the findings of this meta-analysis, there is no support for discontinuing treatment with ACEIs or ARBs in patients with COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Federico Angriman, Laura C. Rosella, Patrick R. Lawler, Dennis T. Ko, Claudio M. Martin, Hannah Wunsch, Damon C. Scales
Summary: Adult sepsis survivors have an increased risk of long-term cardiovascular events, but this risk can be reduced by renin-angiotensin system inhibitors (RASi).
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Fatih Karahan, Vedat Turkoglu
Summary: ACE purified from bovine lung synthesized by endothelial cells was characterized, revealing compound inhibitors and their mechanisms of action.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Cell Biology
Zheng Ma, Mei-Ping Wang, Lian Liu, Shuang Yu, Tian-Ran Wu, Lei Zhao, Ye-Ping Zhang, Hai-Feng Liang, Xin-Chun Yang
Summary: The meta-analysis suggests that the use of ACEI/ARB may increase the risk of COVID-19 infection in the general population, but not in hypertensive individuals. Additionally, ACEI/ARB usage was not associated with adverse outcomes in COVID-19 patients.
Review
Cell Biology
Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amilcar Falcao, M. Teresa Cruz, Ana Fortuna
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by Tau hyperphosphorylation and A beta deposits. Recent scientific evidence suggests that age-related vascular alterations and cardiovascular risk factors play a role in the development of AD. Drugs targeting the Renin Angiotensin System (RAS) have the potential to delay AD development due to their effects on brain RAS. The ACE 1/Ang II/AT1R axis in AD is believed to have detrimental effects, while the alternative axis ACE 1/Ang II/AT2R; ACE 2/Ang (1 7)/MasR; Ang IV/AT4R (IRAP) seems to have beneficial effects on memory and cognition. Retrospective studies and pre-clinical studies support the therapeutic potential of RAS drugs for AD.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Mohitosh Biswas, Most. Sumaiya Khatun Kali
Summary: The use of ACE inhibitors and ARBs in COVID-19 patients was not associated with increased risk of mortality, severe clinical manifestations, or positive SARS-CoV-2 tests compared to patients not taking these medications. The findings suggest that discontinuation of ACE inhibitors or ARBs in treating COVID-19 patients may not be necessary based on current evidence.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Sandeep Singh, Christine Widrich, Martijn Nap, Emile Schokker, Aeilko H. Zwinderman, Sara-Joan Pinto-Sietsma
Summary: A global analysis was conducted to explore the association between antihypertensive medications and SARS-CoV-2 severity. The results suggest that ARBs and CCBs may have a protective effect against death from SARS-CoV-2 infection, while ACEis may be associated with a higher mortality rate.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Article
Urology & Nephrology
Maria Jose Soler, Aida Ribera, Josep R. Marsal, Ana Belen Mendez, Mireia Andres, Maria Antonia Azancot, Gerard Oristrell, Leonardo Mendez-Boo, Jordana Cohen, Jose A. Barrabes, Ignacio Ferreira-Gonzalez
Summary: In a cohort study of HTN patients, it was found that the use of ACEi/ARBs reduced the risk of COVID-19 infection without increasing disease severity.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Shao-Yu Yang, Tao-Min Huang, Tai-Shuan Lai, Nai-Kuan Chou, Chun-Hao Tsao, Yi-Ping Huang, Shuei-Liong Lin, Yung-Ming Chen, Vin-Cent Wu
Summary: The study found that preoperative use of ARBs was associated with a reduced risk of postoperative AKI, especially in high doses, while preoperative use of ACEIs or ARBs was both linked to reduced mortality and did not increase the risk of hyperkalemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Anna Lange, Jonas Sunden-Cullberg, Anders Magnuson, Olof Hultgren
Article
Physiology
A. Soop, J. Sunden-Cullberg, J. Albert, L. Hallstrom, C. -J. Treutiger, A. Sollevi
Article
Immunology
Linda Johansson, Anna Linner, Jonas Sunden-Cullberg, Axana Haggar, Heiko Herwald, Karin Lore, Carl-Johan Treutiger, Anna Norrby-Teglund
JOURNAL OF IMMUNOLOGY
(2009)
Article
Multidisciplinary Sciences
Henrik Antti, Anna Fahlgren, Elin Nasstrom, Konstantinos Kouremenos, Jonas Sunden-Cullberg, YongZhi Guo, Thomas Moritz, Hans Wolf-Watz, Anders Johansson, Maria Fallman
Article
Infectious Diseases
Anna Lange, Sara Cajander, Anders Magnuson, Jonas Sunden-Cullberg, Kristoffer Stralin, Olof Hultgren
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Article
Critical Care Medicine
Jonas Sunden-Cullberg, Anton Nilsson, Malin Inghammar
INTENSIVE CARE MEDICINE
(2020)
Article
Microbiology
David Yu, Anna Larsson, Asa Parke, Christian Unge, Claes Henning, Jonas Sunden-Cullberg, Anna Somell, Kristoffer Stralin, Volkan Ozenci
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Malin Inghammar, Jonas Sunden-Cullberg
Article
Medicine, General & Internal
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sunden Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J. Giamarellos-Bourboulis
Article
Critical Care Medicine
Jonas Sunden-Cullberg, Rebecca Rylance, Jesper Svefors, Anna Norrby-Teglund, Jonas Bjork, Malin Inghammar
CRITICAL CARE MEDICINE
(2017)
Article
Critical Care Medicine
Evangelos J. Giamarellos-Bourboulis, Anna Norrby-Teglund, Vassiliki Mylona, Athina Savva, Iraklis Tsangaris, Ioanna Dimopoulou, Maria Mouktaroudi, Maria Raftogiannis, Marianna Georgitsi, Anna Linner, George Adamis, Anastasia Antonopoulou, Efterpi Apostolidou, Michael Chrisofos, Chrisostomos Katsenos, Ioannis Koutelidakis, Katerina Kotzampassi, George Koratzanis, Marina Koupetori, Ioannis Kritselis, Korina Lymberopoulou, Konstantinos Mandragos, Androniki Marioli, Jonas Sunden-Cullberg, Anna Mega, Athanassios Prekates, Christina Routsi, Charalambos Gogos, Carl-Johan Treutiger, Apostolos Armaganidis, George Dimopoulos
Article
Critical Care Medicine
Jonas Sunden-Cullberg, Thomas Nystrom, Martin L. Lee, Gail E. Mullins, Leif Tokics, Jan Andersson, Anna Norrby-Teglund, Carl Johan Treutiger
CRITICAL CARE MEDICINE
(2007)
Article
Critical Care Medicine
Adam Linder, Per Akesson, Malin Inghammar, Carl-Johan Treutiger, Anna Linner, Jonas Sunden-Cullberg
Review
Infectious Diseases
Jonas Sunden-Cullberg, Anna Norrby-Teglund, Carl Johan Treutiger
CURRENT OPINION IN INFECTIOUS DISEASES
(2006)
